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Cited by 64Acne and Rosacea Treatments and EffectsOvarian function and disordersDermatology and Skin Diseases

Effect of the glycemic index of carbohydrates on acne vulgaris

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Reynolds, Rebecca C., Lee, Stephen, Choi, James Y. J., Atkinson, Fiona S., Stockmann, Karola S., Petocz, Peter, Brand-Miller, Jennie C.·2010·Nutrients
DOI 10.3390/nu2101060PMC PMC3257617
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Abstract

Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m2) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index) completed the study. Diets differed significantly in glycemic index (mean ± standard error of the mean, low glycemic index 51 ± 1 vs. high glycemic index 61 ± 2, p = 0.0002), but not in macronutrient distribution or fiber content. Facial acne improved on both diets (low glycemic index −26 ± 6%, p = 0.0004 and high glycemic index −16 ± 7%, p = 0.01), but differences between diets did not reach significance. Change in insulin sensitivity was not different between diets (low glycemic index 0.2 ± 0.1 and high glycemic index 0.1 ± 0.1, p = 0.60) and did not correlate with change in acne severity (Pearson correlation r = −0.196, p = 0.244). Longer time frames, greater reductions in glycemic load or/and weight loss may be necessary to detect improvements in acne among adolescent boys.

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  • All interventional trials included examined the effect of GI/glycemic load on acne.

    “All the interventional trials included examined the effect of GI/glycemic load on acne (Table IV).47, 48, 49, 50, 51, 52”

    From Diet and acne: A systematic review (2022) · cites this paper as [50]

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Authors
Reynolds, R. C., Lee, S., Choi, J. Y. J., Atkinson, F. S., Stockmann, K. S., Petocz, P., & Brand-Miller, J. C.
Affiliations
  • The University of Sydney (AU)
  • Macquarie University (AU)
Corresponding author
Reynolds, Rebecca C.
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2010-10-18
Volume
2
Issue
10
Pages
1060-1072
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu2101060
PMC
PMC3257617
OpenAlex
W2124194755
Cited by
64
References
1
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 9 · 2017: 1 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 2
FWCI
2.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
acne, glycemic index, low glycemic index diet, insulin sensitivity, insulin resistance, adolescent boys, dietary carbohydrates, androgens, insulin-like growth factor I, inflammatory acne lesions, glycemic load
MeSH terms
Acne Vulgaris, Adolescent, Diet, Dietary Carbohydrates, Humans, Insulin Resistance, Male, Glycemic Index

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