Regulation of vitamin C homeostasis during deficiency
Open accessAbstract
Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%-10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the K(m) of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.
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In a case-control study, patients with periodontal disease had higher vitamin D deficiency (<50 nmol/L) than healthy subjects.
“Laky et al., through a case-control study, observed that patients with periodontal disease were common with higher vitamin D deficiency (<50 nmol/L) than healthy subjects [115].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [115]
Vitamin D values are inversely related to clinical attachment loss and tooth loss in two cross-sectional studies.
“Vitamin D values were found to be inversely related to clinical attachment loss and tooth loss in two cross-sectional studies [115,116].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [115]
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References 140 · Cited by 151
- Authors
- Lindblad, M., Tveden-Nyborg, P., & Lykkesfeldt, J.
- Affiliations
- University of Copenhagen (DK)
- Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, Frederiksberg C 1870, Denmark
- Corresponding author
- Lykkesfeldt, Jens
- ORCID
- Lykkesfeldt, Jens
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2013-07-25
- Volume
- 5
- Issue
- 8
- Pages
- 2860-2879
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC3775232
- OpenAlex
- W2007922873
- Cited by
- 151
- References
- 140
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 14 · 2023: 17 · 2022: 11 · 2021: 20 · 2020: 15 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 11 · 2015: 11 · 2014: 12
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- vitamin C, scurvy, vitamin C transport, vitamin C transporter, transporter kinetics, adaptive mechanisms, vitamin C status
- MeSH terms
- Animals, Ascorbic Acid, Ascorbic Acid Deficiency, Biological Transport, Homeostasis, Humans, Hydrogen-Ion Concentration, Nutritional Status
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