The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Vitamin D and 1,25(OH)2D Regulation of T cells
Open accessAbstract
Vitamin D is a direct and indirect regulator of T cells. The mechanisms by which vitamin D directly regulates T cells are reviewed and new primary data on the effects of 1,25 dihydroxyvitamin D (1,25(OH)2D) on human invariant natural killer (iNK)T cells is presented. The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-γ, IL-17 and induction of IL-4. Experiments in mice demonstrate that the effectiveness of 1,25(OH)2D requires NKT cells, IL-10, the IL-10R and IL-4. Comparisons of mouse and human T cells show that 1,25(OH)2D inhibits IL-17 and IFN-γ, and induces T regulatory cells and IL-4. IL-4 was induced by 1,25(OH)2D in mouse and human iNKT cells. Activation for 72h was required for optimal expression of the vitamin D receptor (VDR) in human and mouse T and iNKT cells. In addition, T cells are potential autocrine sources of 1,25(OH)2D but again only 48–72h after activation. Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-γ, while inducing IL-4 and IL-10, would be beneficial.
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Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · cited 1×
“Th17 cells produce IL-17, IL-22, and granulocyte macrophage-colony stimulating factor (GM-CSF) [11] and are essential for resistance to extracellular pathogens [12].”
BackgroundVitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
Froicu, M., Zhu, Y., & Cantorna, M. T. (2006) · Immunology · doi:10.1111/j.1365-2567.2005.02290.x · Cited by 128
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Could Vitamins Help in the Fight Against COVID-19?
Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020) · Nutrients · doi:10.3390/nu12092550 · Cited by 234
Vitamin D Supplementation: Practical Advice in Different Clinical Settings
Bendotti, G., Biamonte, E., Leporati, P., Goglia, U., Ruggeri, R. M., & Gallo, M. (2025) · Nutrients · doi:10.3390/nu17050783 · Cited by 19
Metadata
- Authors
- Cantorna, M., Snyder, L., Lin, Y.-D., & Yang, L.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2015-04-22
- Volume
- 7
- Issue
- 4
- Pages
- 3011-3021
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2137303237
- Cited by
- 565
- References
- 2
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- gold
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