Cited by 237Birth, Development, and HealthEpigenetics and DNA MethylationNutrition, Genetics, and Disease

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Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood

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Lee, Ho-Sun·2015·Nutrients

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Abstract

Exposure to environmental factors in early life can influence developmental processes and long-term health in humans. Early life nutrition and maternal diet are well-known examples of conditions shown to influence the risk of developing metabolic diseases, including type 2 diabetes mellitus and cardiovascular diseases, in adulthood. It is increasingly accepted that environmental compounds, including nutrients, can produce changes in the genome activity that, in spite of not altering the DNA sequence, can produce important, stable and, in some instances, transgenerational alterations in the phenotype. Epigenetics refers to changes in gene function that cannot be explained by changes in the DNA sequence, with DNA methylation patterns/histone modifications that can make important contributions to epigenetic memory. The epigenome can be considered as an interface between the genome and the environment that is central to the generation of phenotypes and their stability throughout the life course. To better understand the role of maternal health and nutrition in the initiation and progression of diseases in childhood and adulthood, it is necessary to identify the physiological and/or pathological roles of specific nutrients on the epigenome and how dietary interventions in utero and early life could modulate disease risk through epigenomic alteration.

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Authors: Lee, H.-S.
Affiliations: Centre international de recherche sur le cancer (FR)
Corresponding author: Lee, Ho-Sun
ORCID: Lee, Ho-Sun
Venue: Nutrients
Publisher: MDPI AG
Published: 2015-11-17
Volume: 7
Issue: 11
Pages: 9492-9507
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu7115467
PMC: PMC4663595
OpenAlex: W2177368991
Semantic Scholar: c27867817e6f8bd06ffbdf5221390da50aadffbd
Cited by: 236
References: 107
Citations by year: 2026: 14 · 2025: 19 · 2024: 12 · 2023: 20 · 2022: 25 · 2021: 19 · 2020: 23 · 2019: 32 · 2018: 33 · 2017: 23 · 2016: 16
FWCI: 3.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: World Health Organization
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: maternal diet, epigenetics, DNA methylation, histone modifications, developmental programming, early life nutrition, type 2 diabetes, cardiovascular disease, metabolic disorders, transgenerational epigenetic inheritance, prenatal exposure, dietary intervention
MeSH terms: Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diet, Disease Models, Animal, Female, Humans, Nutritional Status, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, DNA Methylation, Maternal Nutritional Physiological Phenomena, Epigenesis, Genetic, Epigenomics, Gene-Environment Interaction

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Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood

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