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Cited by 144Birth, Development, and HealthEpigenetics and DNA MethylationNutrition, Genetics, and Disease

Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome

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Chango, Abalo, Pogribny, Igor·2015·Nutrients
DOI 10.3390/nu7042748PMC PMC4425171
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Abstract

Fetal life is characterized by a tremendous plasticity and ability to respond to various environmental and lifestyle factors, including maternal nutrition. Identification of the role of dietary factors that can modulate and reshape the cellular epigenome during development, including methyl group donors (e.g., folate, choline) and bioactive compounds (e.g., polyphenols) is of great importance; however, there is insufficient knowledge of a particular effect of each type of modulator and/or their combination on fetal life. To enhance the quality and safety of food products for proper fetal health and disease prevention in later life, a better understanding of the underlying mechanisms of dietary epigenetic modulators during the critical prenatal period is necessary. This review focuses on the influence of maternal dietary components on DNA methylation, histone modification, and microRNAs, and summarizes current knowledge of the effect and importance of dietary components on epigenetic mechanisms that control the proper expression of genetic information. Evidence reveals that some components in the maternal diet can directly or indirectly affect epigenetic mechanisms. Understanding the underlying mechanisms of how early-life nutritional environment affects the epigenome during development is of great importance for the successful prevention of adult chronic diseases through optimal maternal nutrition.

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  • These micronutrient deficiencies contribute not only to immediate pregnancy complications but also to persistent alterations in fetal growth, neurodevelopment, and metabolic programming, often mediated through epigenetic mechanisms.

    “These deficiencies contribute not only to immediate pregnancy complications but also to persistent alterations in fetal growth, neurodevelopment, and metabolic programming, often mediated through epigenetic mechanisms [89,90].”

    From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [89]

    Section 1 (Introduction) says deficiencies in methyl-group donors can cause lasting epigenetic and phenotypic changes, and §3.4 links methyl-donor restriction to adverse offspring phenotypes and altered DNA methylation. Section 6 also links dietary components to metabolic programming. The copy does not establish that micronutrient deficiencies cause the cited pregnancy complications or persistent neurodevelopmental changes; §3.4 discusses growth restriction and preeclampsia in relation to placental maladaptation, not specifically deficiency. Page numbers are unavailable in the indexed passages. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Chango, A., & Pogribny, I.
Affiliations
  • Institut polytechnique LaSalle Beauvais (FR)
  • National Center for Toxicological Research (US)
Corresponding author
Chango, Abalo
ORCID
Pogribny, Igor
Venue
Nutrients
Publisher
MDPI AG
Published
2015-04-14
Volume
7
Issue
4
Pages
2748-2770
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu7042748
PMC
PMC4425171
OpenAlex
W2127552529
Cited by
144
References
12
Citations by year
2026: 5 · 2025: 11 · 2024: 6 · 2023: 6 · 2022: 16 · 2021: 11 · 2020: 12 · 2019: 19 · 2018: 13 · 2017: 25 · 2016: 14 · 2015: 6
FWCI
2.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
maternal nutrition, fetal epigenome, DNA methylation, histone modifications, microRNA, folic acid, choline, polyphenols, methyl donors, prenatal programming, epigenetic regulation, early life nutrition, chronic disease prevention
MeSH terms
Energy Intake, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Female, Fetus, Humans, Pregnancy, Micronutrients, Prenatal Nutritional Physiological Phenomena, Epigenesis, Genetic, Epigenomics

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