The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances
Open accessAbstract
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human health and development, and numerous fatty acid desaturases play key roles in synthesizing PUFAs. Given the lack of delta-12 and -15 desaturases and the low levels of conversion to PUFAs, humans must consume some omega-3 and omega-6 fatty acids in their diet. Many studies on fatty acid desaturases as well as PUFAs have shown that fatty acid desaturase genes are closely related to different human physiological conditions. Since the first front-end desaturases from cyanobacteria were cloned, numerous desaturase genes have been identified and animals and plants have been genetically engineered to produce PUFAs such as eicosapentaenoic acid and docosahexaenoic acid. Recently, a biotechnological approach has been used to develop clinical treatments for human physiological conditions, including cancers and neurogenetic disorders. Thus, understanding the functions and regulation of PUFAs associated with human health and development by using biotechnology may facilitate the engineering of more advanced PUFA production and provide new insights into the complexity of fatty acid metabolism.
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Cites
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Cited by
Lipid metabolism in cancer: New perspectives and emerging mechanisms
Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S.-M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.013 · Cited by 758
Dietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits
Kapoor, B., Kapoor, D., Gautam, S., Singh, R., & Bhardwaj, S. (2021) · Current Nutrition Reports · doi:10.1007/s13668-021-00363-3 · Cited by 418
Singh, R., Parihar, P., Singh, M., Bajguz, A., Kumar, J., Singh, S., Singh, V. P., & Prasad, S. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00515 · Cited by 398
Fatty acid metabolism in the progression and resolution of CNS disorders
Bogie, J. F. J., Haidar, M., Kooij, G., & Hendriks, J. J. A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.01.004 · Cited by 167
Biosynthesis of Triacylglycerol Molecules with a Tailored PUFA Profile in Industrial Microalgae
Xin, Y., Shen, C., She, Y., Chen, H., Wang, C., Wei, L., Yoon, K., Han, D., Hu, Q., & Xu, J. (2019) · Molecular Plant · doi:10.1016/j.molp.2018.12.007 · Cited by 108
Metadata
- Authors
- Lee, J., Lee, H., Kang, S., & Park, W.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2016-01-04
- Volume
- 8
- Issue
- 1
- Pages
- 23
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2217305406
- Cited by
- 398
- References
- 92
- FWCI
- 28.86
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
