Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study
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Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1–SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = −2.56 (0.96); SQ4: −2.16 (1.06)) and women (SQ1: −1.10 (0.52); SQ4: −1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (−0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men.
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During periods of the year when sunshine is at a relative minimum and in the absence of vitamin D supplementation, there is an accelerated loss of muscle mass in elderly people.
“Granic and co-workers [70] demonstrated that during periods of the year when sunshine is at a relative minimum and in the absence of vitamin D supplementation, there is an accelerated loss of muscle mass in elderly people.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [70]
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References 57 · Cited by 74
- Authors
- Granic, A., Hill, T., Davies, K., Jagger, C., Adamson, A., Siervo, M., Kirkwood, T., Mathers, J., & Sayer, A.
- Affiliations
- NIHR Newcastle Biomedical Research Centre (GB)
- Newcastle University (GB)
- Corresponding author
- Sayer, Avan
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-04-13
- Volume
- 9
- Issue
- 4
- Pages
- 379
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5409718
- OpenAlex
- W2606810335
- Cited by
- 74
- References
- 57
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 12 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 1
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- National Institute for Health Research Newcastle Biomedical Research Centre
- Medical Research Council and Biotechnology and Biomedical Science Research Council (G0500997)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- vitamin D status, 25-hydroxyvitamin D, muscle strength, grip strength, physical performance decline, Timed Up and Go test, muscle aging, oldest old, sex differences, seasonal variation, Newcastle 85+ Study
- MeSH terms
- Aged, 80 and over, Calcifediol, Female, United Kingdom, Humans, Longitudinal Studies, Male, Nutritional Status, Prospective Studies, Psychomotor Performance, Risk, Seasons, Sex Factors, Vitamin D, Vitamin D Deficiency, Cohort Studies, 25-Hydroxyvitamin D 2, Disease Progression, Dietary Supplements, Muscle Strength, Sarcopenia, Self Report, Elder Nutritional Physiological Phenomena
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