The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms
Open accessAbstract
Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least 12 months. We searched PubMed and Embase for papers reporting at least one-year follow-up results of COVID-19 survivors published by 6 November 2021. Random-effects meta-analyses were conducted to estimate pooled prevalence of specific post-COVID symptoms. Eighteen papers that reported one-year follow-up data from 8591 COVID-19 survivors were included. Fatigue/weakness (28%, 95% CI: 18–39), dyspnoea (18%, 95% CI: 13–24), arthromyalgia (26%, 95% CI: 8–44), depression (23%, 95% CI: 12–34), anxiety (22%, 95% CI: 15–29), memory loss (19%, 95% CI: 7–31), concentration difficulties (18%, 95% CI: 2–35), and insomnia (12%, 95% CI: 7–17) were the most prevalent symptoms at one-year follow-up. Existing evidence suggested that female patients and those with more severe initial illness were more likely to suffer from the sequelae after one year. This study demonstrated that a sizeable proportion of COVID-19 survivors still experience residual symptoms involving various body systems one year later. There is an urgent need for elucidating the pathophysiologic mechanisms and developing and testing targeted interventions for long-COVID patients.
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Cites
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Cited by
Notarte, K. I., Catahay, J. A., Velasco, J. V., Pastrana, A., Ver, A. T., Pangilinan, F. C., Peligro, P. J., Casimiro, M., Guerrero, J. J., Gellaco, M. M. L., et al. (2022) · eClinicalMedicine · doi:10.1016/j.eclinm.2022.101624 · Cited by 480
Notarte, K. I., de Oliveira, M. H. S., Peligro, P. J., Velasco, J. V., Macaranas, I., Ver, A. T., Pangilinan, F. C., Pastrana, A., Goldrich, N., Kavteladze, D., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247314 · Cited by 209
Fernández-de-las-Peñas, C., Notarte, K. I., Peligro, P. J., Velasco, J. V., Ocampo, M. J., Henry, B. M., Arendt-Nielsen, L., Torres-Macho, J., & Plaza-Manzano, G. (2022) · Viruses · doi:10.3390/v14122629 · Cited by 184
Lionte, C., Sorodoc, V., Haliga, R. E., Bologa, C., Ceasovschih, A., Petris, O. R., Coman, A. E., Stoica, A., Sirbu, O., Puha, G., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12061373 · Cited by 36
Metadata
- Authors
- Han, Q., Zheng, B., Daines, L., & Sheikh, A.
- Venue
- Pathogens
- Publisher
- MDPI AG
- Published
- 2022-02-19
- Volume
- 11
- Issue
- 2
- Pages
- 269
- ISSN
- 2076-0817 (ISSN-L)
- OpenAlex
- W4213189887
- Cited by
- 572
- References
- 10
- FWCI
- 22.89
- Type
- journal article
- Language
- en
- Open access
- gold
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