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Cited by 572

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms

Open access
Han, Qing, Zheng, Bang, Daines, Luke, Sheikh, Aziz·2022·Pathogens

Abstract

Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least 12 months. We searched PubMed and Embase for papers reporting at least one-year follow-up results of COVID-19 survivors published by 6 November 2021. Random-effects meta-analyses were conducted to estimate pooled prevalence of specific post-COVID symptoms. Eighteen papers that reported one-year follow-up data from 8591 COVID-19 survivors were included. Fatigue/weakness (28%, 95% CI: 18–39), dyspnoea (18%, 95% CI: 13–24), arthromyalgia (26%, 95% CI: 8–44), depression (23%, 95% CI: 12–34), anxiety (22%, 95% CI: 15–29), memory loss (19%, 95% CI: 7–31), concentration difficulties (18%, 95% CI: 2–35), and insomnia (12%, 95% CI: 7–17) were the most prevalent symptoms at one-year follow-up. Existing evidence suggested that female patients and those with more severe initial illness were more likely to suffer from the sequelae after one year. This study demonstrated that a sizeable proportion of COVID-19 survivors still experience residual symptoms involving various body systems one year later. There is an urgent need for elucidating the pathophysiologic mechanisms and developing and testing targeted interventions for long-COVID patients.

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Metadata

Authors
Han, Q., Zheng, B., Daines, L., & Sheikh, A.
Venue
Pathogens
Publisher
MDPI AG
Published
2022-02-19
Volume
11
Issue
2
Pages
269
ISSN
2076-0817 (ISSN-L)
OpenAlex
W4213189887
Cited by
572
References
10
FWCI
22.89
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. https://app.cochat.ai/papers/10.3390/pathogens11020269
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Han, Q., Zheng, B., Daines, L., & Sheikh, A. (2022). Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. Pathogens. https://doi.org/10.3390/pathogens11020269

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