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Cited by 119Psychedelics and Drug StudiesForensic Toxicology and Drug AnalysisAlkaloids: synthesis and pharmacology

The DOI matches its Crossref record; 217 of the 218 references it cites were found in a registry or an index.

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact

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Brito-da-Costa, Andreia Machado, Dias-da-Silva, Diana, Gomes, Nelson G. M., Dinis-Oliveira, Ricardo Jorge, Madureira-Carvalho, Áurea·2020·Pharmaceuticals
DOI 10.3390/ph13110334PMC PMC7690791
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Abstract

Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and bark of Banisteriopsis caapi, the plant source of harmala alkaloids. Herein, the toxicokinetics and toxicodynamics of the psychoactive DMT and harmala alkaloids harmine, harmaline and tetrahydroharmine, are comprehensively covered, particularly emphasizing the psychological, physiological, and toxic effects deriving from their concomitant intake. Potential therapeutic utility, particularly in mental and psychiatric disorders, and forensic aspects of DMT and ayahuasca are also reviewed and discussed. Following administration of ayahuasca, DMT is rapidly absorbed and distributed. Harmala alkaloids act as potent inhibitors of monoamine oxidase A (MAO-A), preventing extensive first-pass degradation of DMT into 3-indole-acetic acid (3-IAA), and enabling sufficient amounts of DMT to reach the brain. DMT has affinity for a variety of serotonergic and non-serotonergic receptors, though its psychotropic effects are mainly related with the activation of serotonin receptors type 2A (5-HT2A). Mildly to rarely severe psychedelic adverse effects are reported for ayahuasca or its alkaloids individually, but abuse does not lead to dependence or tolerance. For a long time, the evidence has pointed to potential psychotherapeutic benefits in the treatment of depression, anxiety, and substance abuse disorders; and although misuse of ayahuasca has been diverting attention away from such clinical potential, research onto its therapeutic effects has now strongly resurged.

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  1. Strassman, R.J. (2001). DMT: The Spirit Molecule: A Doctor’s Revolutionary Research into the Biology of Near-Death and Mystical Experiences, Park Street Press.
  2. Rall, T.W., Nies, A.S., and Taylor, P. (1990). Drug addiction and drug abuse. Goodman and Gilman’s the Pharmacological Basis of Therapeutics, McGraw-Hill.
  3. Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, R.W., and Gilman, A.G. (2018). Drug Use Disorders and Addiction. Goodman and Gilman’s the Pharmacological Basis of Therapeutics, McGraw-Hill.
  4. Hofmann, A. (1976). LSD—My Problem Child, McGraw-Hill.
  5. Schultes, 1972, Ethnotoxocological significance of additives to New World hallucinogens, Plant Sci. Bull., 18, 34
  6. Moffat, A.C., Osselton, M.D., Widdop, B., and Watts, J. (2011). Clarke’s Analysis of Drugs and Poisons, Pharmaceutical Press. [4th ed.].
  7. National Center for Biotechnology Information (2020, July 29). PubChem Compound Summary for CID 6089, N,N-Dimethyltryptamine, Available online: https://pubchem.ncbi.nlm.nih.gov/compound/N_N-Dimethyltryptamine.
  8. National Center for Biotechnology Information (2020, July 29). PubChem Compound Summary for CID 3564, Harmaline, Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Harmaline.
  9. National Center for Biotechnology Information (2020, July 29). PubChem Compound Summary for CID 159809, Tetrahydroharmine, Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydroharmine.
  10. Naranjo, 1959, Estudio comparativo de la harmina, la dietilamida del ácido lisérgico (LSD-25) y la mescalina, Rev. Confed. Médica Panam., 6, 1
  11. Warren, 2004, Fatal nicotine intoxication resulting from the ingestion of “ayahuasca”, J. Anal. Toxicol., 28, 287
  12. Metzner, R. (1999). The psychology of ayahuasca. Ayahuasca: Hallucinogens, Consciousness, and the Spirit of Nature, Thunder’s Mouth Press.

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Metadata

Authors
Brito-da-Costa, A. M., Dias-da-Silva, D., Gomes, N. G. M., Dinis-Oliveira, R. J., & Madureira-Carvalho, Á.
Affiliations
  • Cooperativa de Ensino Superior Politécnico e Universitário (PT)
  • Department of Sciences, IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal
  • Universidade do Porto (PT)
ORCID
Venue
Pharmaceuticals
Publisher
MDPI AG
Published
2020-10-23
Volume
13
Issue
11
Pages
334
ISSN
1424-8247 (ISSN-L)
DOI
10.3390/ph13110334
PMC
PMC7690791
OpenAlex
W3094461574
Cited by
117
References
218
Citations by year
2026: 13 · 2025: 24 · 2024: 25 · 2023: 22 · 2022: 25 · 2021: 7
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceuticals (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
Keywords
ayahuasca, N,N-dimethyltryptamine, harmine, harmaline, tetrahydroharmine, harmala alkaloids, toxicokinetics, toxicodynamics, monoamine oxidase A inhibition, Psychotria viridis, Banisteriopsis caapi, 5-HT2A receptor, forensic toxicology, psychedelic therapy, depression, anxiety, substance use disorders

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