Cited by 298Inflammatory mediators and NSAID effectsAcute Kidney Injury ResearchEicosanoids and Hypertension Pharmacology

Nonsteroidal Anti-Inflammatory Drugs and the Kidney

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Hörl, Walter H.·2010·Pharmaceuticals

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly patients and those with co-morbibity (e.g., congestive heart failure, liver cirrhosis or chronic kidney disease) and drug combinations (e.g., renin-angiotensin blockers, diuretics plus NSAIDs) may develop acute renal failure. This review summarizes our present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension may result.

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  1. [29]Leehey D.J. Uckerman M.T. Rahman M.A. Role of prostaglandins and thromboxane in the control of renal hemodynamics in experimental liver cirrhosis J. Lab. Clin. Med. 1989 113 309 315 2926239
  2. [186]Johnson A.G. Nguyen T.V. Day R.O. Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis Ann. Intern. Med. 1994 121 289 300 8037411
  3. [189]Wang J.L. Cheng H.F. Harris R.C. Cyclooxygenase-2 Inhibition Decreases Renin Content and Lowers Blood Pressure in a Model of Renovascular Hypertension Hypertension 1999 34 96 101 10406830
  4. [203]Atta MG. Whelton A. Acute renal papillary necrosis induced by ibuprofen Am. J. Ther. 1997 4 55 60 10423592

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Authors
Hörl, W. H.
Affiliations
Medical University of Vienna (AT)
Corresponding author
Hörl, Walter H.
Venue
Pharmaceuticals
Publisher
MDPI AG
Published
2010-07-21
Volume
3
Issue
7
Pages
2291-2321
ISSN
1424-8247 (ISSN-L)
OpenAlex
W2006081951
Cited by
298
References
242
Citations by year
2026: 23 · 2025: 25 · 2024: 37 · 2023: 19 · 2022: 29 · 2021: 26 · 2020: 31 · 2019: 41 · 2018: 33 · 2017: 10 · 2016: 7 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 5
FWCI
0.36
Type
journal article
Language
en
Open access
Locations
  • Pharmaceuticals (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
nonsteroidal anti-inflammatory drugs, NSAID nephrotoxicity, cyclooxygenase-2, cyclooxygenase-1, COX-2 inhibitors, acute kidney injury, renal function, renal inflammation, sodium-potassium balance, hypertension, elderly patients, chronic kidney disease, diuretics, drug interactions

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