Nonsteroidal Anti-Inflammatory Drugs and the Kidney
Open accessAbstract
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly patients and those with co-morbibity (e.g., congestive heart failure, liver cirrhosis or chronic kidney disease) and drug combinations (e.g., renin-angiotensin blockers, diuretics plus NSAIDs) may develop acute renal failure. This review summarizes our present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension may result.
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Blood pressure effects from the use of NSAIDs vary by type, with selective COX-2 inhibitors such as celecoxib having less blood pressure effect than traditional NSAIDs.
“BP effects from the use of NSAIDs vary by type, with selective COX-2 (cyclooxygenase-2) inhibitors such as celecoxib having less BP effect than traditional NSAIDs.192,202”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [192]
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Nephrotic Syndrome and Acute Tubular Necrosis Due to Meloxicam Use
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- Authors
- Hörl, W. H.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Hörl, Walter H.
- Venue
- Pharmaceuticals
- Publisher
- MDPI AG
- Published
- 2010-07-21
- Volume
- 3
- Issue
- 7
- Pages
- 2291-2321
- ISSN
- 1424-8247 (ISSN-L)
- PMC
- PMC4036662
- OpenAlex
- W2006081951
- Cited by
- 298
- References
- 242
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 37 · 2023: 19 · 2022: 29 · 2021: 26 · 2020: 31 · 2019: 41 · 2018: 33 · 2017: 10 · 2016: 7 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceuticals (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nonsteroidal anti-inflammatory drugs, NSAID nephrotoxicity, cyclooxygenase-2, cyclooxygenase-1, COX-2 inhibitors, acute kidney injury, renal function, renal inflammation, sodium-potassium balance, hypertension, elderly patients, chronic kidney disease, diuretics, drug interactions
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