The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Antimicrobial Peptides
Open accessAbstract
The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic peptides with a wide spectrum of targets including viruses, bacteria, fungi, and parasites. We summarize the major types of AMPs, their modes of action, and the common mechanisms of AMP resistance. In addition, we discuss the principles for designing effective AMPs and the potential of using AMPs to control biofilms (multicellular structures of bacteria embedded in extracellular matrixes) and persister cells (dormant phenotypic variants of bacterial cells that are highly tolerant to antibiotics).
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Anti-microbial peptides: from invertebrates to vertebrates
Bulet, P., Stöcklin, R., & Menin, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0124.x · Cited by 1,107
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Cationic Antimicrobial Peptides: Issues for Potential Clinical Use
Bradshaw, J. P. (2003) · BioDrugs · doi:10.2165/00063030-200317040-00002 · Cited by 293
Cathelicidin family of antimicrobial peptides: Proteolytic processing and protease resistance
Shinnar, A. E., Butler, K. L., & Park, H. J. (2003) · Bioorganic Chemistry · doi:10.1016/s0045-2068(03)00080-4 · Cited by 170
Cited by
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
Ong, Z. Y., Wiradharma, N., & Yang, Y. Y. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.013 · Cited by 313
Antimicrobial peptides: Structure, mechanism, and modification
Chen, N., & Jiang, C. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115377 · Cited by 279
Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle.
Steinberg, R., Origi, A., Natriashvili, A., Sarmah, P., Licheva, M., Walker, P. M., Kraft, C., High, S., Luirink, J., Shi, W. Q., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000874 · Cited by 34
Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity
Xue, Y.-P., Kao, M.-C., & Lan, C.-Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-50114-2 · Cited by 25
Metadata
- Authors
- Bahar, A., & Ren, D.
- Venue
- Pharmaceuticals
- Publisher
- MDPI AG
- Published
- 2013-11-28
- Volume
- 6
- Issue
- 12
- Pages
- 1543-1575
- ISSN
- 1424-8247 (ISSN-L)
- OpenAlex
- W4210968711
- Cited by
- 1,351
- References
- 7
- FWCI
- 29.88
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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