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Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

Iglesias, Guillermo R., Jabalera, Ylenia, Peigneux, Ana, Checa Fernández, Blanca Luna, Delgado, Ángel V., Jimenez-Lopez, Concepcion·2019·Pharmaceutics
DOI 10.3390/pharmaceutics11060273PMC PMC6631210
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Abstract

In this work we report on the synthesis and characterization of magnetic nanoparticles of two distinct origins, one inorganic (MNPs) and the other biomimetic (BMNPs), the latter based on a process of bacterial synthesis. Each of these two kinds of particles has its own advantages when used separately with biomedical purposes. Thus, BMNPs present an isoelectric point below neutrality (around pH 4.4), while MNPs show a zero-zeta potential at pH 7, and appear to be excellent agents for magnetic hyperthermia. This means that the biomimetic particles are better suited to be loaded with drug molecules positively charged at neutral pH (notably, doxorubicin, for instance) and releasing it at the acidic tumor environment. In turn, MNPs may provide their transport capabilities under a magnetic field. In this study it is proposed to use a mixture of both kinds of particles at two different concentrations, trying to get the best from each of them. We study which mixture performs better from different points of view, like stability and magnetic hyperthermia response, while keeping suitable drug transport capabilities. This composite system is proposed as a close to ideal drug vehicle with added enhanced hyperthermia response.

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Figure 1 Diameter histograms (A,C) and TEM pictures (B,D) of biomimetic (BMNPs) and purely inorganic (MNPs) magnetic nanoparticles. The scale bar in B, D is 200 nm.
Figure 1 Diameter histograms (A,C) and TEM pictures (B,D) of biomimetic (BMNPs) and purely inorganic (MNPs) magnetic nanoparticles. The scale bar in B, D is 200 nm.CC BY · PubMed Central
Figure 2 The XRD diffraction patterns of purely inorganic (MNPs) and biomimetic magnetic nanoparticles (BMNPs). The positions and intensities of crystallographically-pure magnetite are labeled as M, and those of goethite as G.
Figure 2 The XRD diffraction patterns of purely inorganic (MNPs) and biomimetic magnetic nanoparticles (BMNPs). The positions and intensities of crystallographically-pure magnetite are labeled as M, and those of goethite as G.CC BY · PubMed Central
Figure 3 Magnetization cycles of MNPs (■), BMNPs (●), and 25 B + 75 M (♦) at 5 K (top), and 300 K (bottom). Magnifications of the low-field region are also plotted.
Figure 3 Magnetization cycles of MNPs (■), BMNPs (●), and 25 B + 75 M (♦) at 5 K (top), and 300 K (bottom). Magnifications of the low-field region are also plotted.CC BY · PubMed Central
Figure 4 Zero field cooling-field cooling (ZFC-FC) curves at 40 kA/m of MNPs (■), BMNPs (●) and 25 B + 75 M (♦).
Figure 4 Zero field cooling-field cooling (ZFC-FC) curves at 40 kA/m of MNPs (■), BMNPs (●) and 25 B + 75 M (♦).CC BY · PubMed Central
Figure 5 Zeta potential of purely inorganic MNPs (■) and biomimetic magnetic nanoparticles BMNPs (●).
Figure 5 Zeta potential of purely inorganic MNPs (■) and biomimetic magnetic nanoparticles BMNPs (●).CC BY · PubMed Central
Figure 6 Height of the sedimented volume relative to its initial value as a function of time for MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Inset: Short-time detail.
Figure 6 Height of the sedimented volume relative to its initial value as a function of time for MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Inset: Short-time detail.CC BY · PubMed Central
Figure 7 Time evolution of the temperature of the MNP suspensions, for different frequencies: 197 kHz (●), 236 kHz (▲), and 280 kHz (♦). Field strength: H0 = 18 kA/m. Sample volume 0.5 mL; particle concentration: 25 mg/mL.
Figure 7 Time evolution of the temperature of the MNP suspensions, for different frequencies: 197 kHz (●), 236 kHz (▲), and 280 kHz (♦). Field strength: H0 = 18 kA/m. Sample volume 0.5 mL; particle concentration: 25 mg/mL.CC BY · PubMed Central
Figure 8 Frequency dependence of (a) SAR and (b) ILP, for the investigated systems. MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Magnetic field strength: 18 kA/m; particle concentration: 25 mg/mL.
Figure 8 Frequency dependence of (a) SAR and (b) ILP, for the investigated systems. MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Magnetic field strength: 18 kA/m; particle concentration: 25 mg/mL.CC BY · PubMed Central

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Metadata

Authors
Iglesias, G. R., Jabalera, Y., Peigneux, A., Checa Fernández, B. L., Delgado, Á. V., & Jimenez-Lopez, C.
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2019-06-11
Volume
11
Issue
6
Pages
273
ISSN
1999-4923
DOI
10.3390/pharmaceutics11060273
PMC
PMC6631210
Cited by
36
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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