Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions
Open accessAbstract
Paediatric infectious diseases contribute significantly to global health challenges. Conventional therapeutic interventions are not always suitable for children, as they are regularly accompanied with long-standing disadvantages that negatively impact efficacy, thus necessitating the need for effective and child-friendly pharmacotherapeutic interventions. Recent advancements in drug delivery technologies, particularly oral formulations, have shown tremendous progress in enhancing the effectiveness of paediatric medicines. Generally, these delivery methods target, and address challenges associated with palatability, dosing accuracy, stability, bioavailability, patient compliance, and caregiver convenience, which are important factors that can influence successful treatment outcomes in children. Some of the emerging trends include moving away from creating liquid delivery systems to developing oral solid formulations, with the most explored being orodispersible tablets, multiparticulate dosage forms using film-coating technologies, and chewable drug products. Other ongoing innovations include gastro-retentive, 3D-printed, nipple-shield, milk-based, and nanoparticulate (e.g., lipid-, polymeric-based templates) drug delivery systems, possessing the potential to improve therapeutic effectiveness, age appropriateness, pharmacokinetics, and safety profiles as they relate to the paediatric population. This manuscript therefore highlights the evolving landscape of oral pharmacotherapeutic interventions for leading paediatric infectious diseases, crediting the role of innovative drug delivery technologies. By focusing on the current trends, pointing out gaps, and identifying future possibilities, this review aims to contribute towards ongoing efforts directed at improving paediatric health outcomes associated with the management of these infectious ailments through accessible and efficacious drug treatments.
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Deposition of a PDA nanolayer on demineralized enamel surfaces functionally mimics natural organic matrices such as amelogenin and provides nucleation sites for selective adsorption of calcium and phosphate ions, guiding ordered hydroxyapatite crystal formation with structural characteristics highly similar to native enamel.
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Single-dose therapy for giardiasis in school-age children.
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Tuberculosis in children, adolescents, and women
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The osmotic stress response of split influenza vaccine particles in an acidic environment
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Optimal First-Line Treatment for Helicobacter pylori Infection: Recent Strategies
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Flagged first, then by citations
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Imbriano, A., Fratini, C., Bondi, G., D’Abbrunzo, I., Bertoni, S., Tiboni, M., Abruzzo, A., Hasa, D., Pagano, C., & Casettari, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125645 · Cited by 13 · see citing works
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Synthesis and Antitumor Activity of New Metronidazole‐Linked Thiophene or Pyrazole Analogues
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Harnessing Stem Cells for Pediatric Respiratory Diseases: Potential and Clinical Translation
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Pioneering era in paediatric tuberculosis: Utilization of 3D printing technology
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Optimization of Antiviral Therapies among Pediatrics: Confronting Remedying Unique Challenges
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Recent Advances in Pediatric Infectious Diseases: A Review of Diagnostic and Therapeutic Strategies
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Osteomyelitis in HIV pathogenesis, challenges, and therapeutic strategies
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“24 In addition, PDA coatings have been shown to inhibit bacterial adhesion and biofilm formation on enamel surfaces, thereby contributing to the prevention of secondary caries.”
Moges, T. A., Dagnew, F. N., Tarekegn, G. Y., Wondm, S. A., Zewdu, W. S., Anberbr, S. S., Nigussie, H., & Dagnew, S. B. (2026) · BioMed Research International · doi:10.1155/bmri/8893135
Formulation and Evaluation of Anti-Inflammatory Chewable Gummies on Asthenopia Syndrome
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Shi, Y., Ma, H., Han, W., & Li, D. (2026) · IET Nanobiotechnology · doi:10.1049/nbt2/2692282
- Authors
- Rampedi, P. N., Ogunrombi, M. O., & Adeleke, O. A.
- Affiliations
- Sefako Makgatho Health Sciences University (ZA)
- Dalhousie University (CA)
- Corresponding author
- Adeleke, Oluwatoyin A.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2024-05-26
- Volume
- 16
- Issue
- 6
- Pages
- 712
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC11206886
- OpenAlex
- W4399042646
- Cited by
- 15
- References
- 256
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 1
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation, South Africa (113143, D112-RDG, M053-MRC, R34000)
- Department of Higher Education and Training, South Africa (113143, D112-RDG, M053-MRC, R34000)
- South African Medical Research Council (113143, D112-RDG, M053-MRC, R34000)
- Faculty of Health and College of Pharmacy, Dalhousie University, Canada (113143, D112-RDG, M053-MRC, R34000)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- pediatric infection, oral drug delivery, pediatric formulations, orally disintegrating tablets, multiparticulate dosage forms, chewable tablets, gastroretentive drug delivery, nanoparticle drug delivery, lipid nanoparticles, polymeric nanoparticles, bioavailability, medication adherence, dose accuracy, palatability
About these checks
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