Cited by 16Pharmaceutical studies and practicesAdvanced Drug Delivery SystemsDrug Solubulity and Delivery Systems

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Open access
Rampedi, Penelope N., Ogunrombi, Modupe O., Adeleke, Oluwatoyin A.·2024·Pharmaceutics

Abstract

Paediatric infectious diseases contribute significantly to global health challenges. Conventional therapeutic interventions are not always suitable for children, as they are regularly accompanied with long-standing disadvantages that negatively impact efficacy, thus necessitating the need for effective and child-friendly pharmacotherapeutic interventions. Recent advancements in drug delivery technologies, particularly oral formulations, have shown tremendous progress in enhancing the effectiveness of paediatric medicines. Generally, these delivery methods target, and address challenges associated with palatability, dosing accuracy, stability, bioavailability, patient compliance, and caregiver convenience, which are important factors that can influence successful treatment outcomes in children. Some of the emerging trends include moving away from creating liquid delivery systems to developing oral solid formulations, with the most explored being orodispersible tablets, multiparticulate dosage forms using film-coating technologies, and chewable drug products. Other ongoing innovations include gastro-retentive, 3D-printed, nipple-shield, milk-based, and nanoparticulate (e.g., lipid-, polymeric-based templates) drug delivery systems, possessing the potential to improve therapeutic effectiveness, age appropriateness, pharmacokinetics, and safety profiles as they relate to the paediatric population. This manuscript therefore highlights the evolving landscape of oral pharmacotherapeutic interventions for leading paediatric infectious diseases, crediting the role of innovative drug delivery technologies. By focusing on the current trends, pointing out gaps, and identifying future possibilities, this review aims to contribute towards ongoing efforts directed at improving paediatric health outcomes associated with the management of these infectious ailments through accessible and efficacious drug treatments.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/pharmaceutics16060712

Cites

253 of 255 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Deposition of a PDA nanolayer on demineralized enamel surfaces functionally mimics natural organic matrices such as amelogenin and provides nucleation sites for selective adsorption of calcium and phosphate ions, guiding ordered hydroxyapatite crystal formation with structural characteristics highly similar to native enamel.

    “It has been reported that the deposition of a PDA nanolayer on demineralized enamel surfaces can functionally mimic the role of natural organic matrices, such as amelogenin, during enamel formation.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [24]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 256 references couldn’t be matched to a known paper.

Research works printed but not linked: 10

  1. [17]Kachru N. Clinical pharmacology of anesthetic drugs in neonates anesthetic drugs in neonates Clinical Anesthesia for the Newborn and the Neonate Springer Nature Singapore 2023 327 348
  2. [22]Ryan E.T. Hill D.R. Solomon T. Aronson N. Endy T.P. Hunter’s Tropical Medicine and Emerging Infectious Diseases E-Book Elsevier Health Sciences Amsterdam, The Netherlands 2019
  3. [23]Long S.S. Prober C.G. Fischer M. Principles and Practice of Paediatric Infectious Diseases E-Book Elsevier Health Sciences Amsterdam, The Netherlands 2022
  4. [53]Mustafa M.A. ur Rehman N.S. Khan A.M. Munir M. Azhar K. Ahmed F. Imran A. Arif M. Latif M.U. Ijaz A. Formulation and in vitro Evaluation of Natural Polymer Based Albendazole Gummies: A Novel Paediatrics Dosage Form J. Young Pharm. 2023 15 478 484 10.5530/jyp.2023.15.63 · DOI
  5. [54]Arora K. Vats V. Verma P.K. A Review on Pharmaceutical Suspension and Its Advancement Ann. Clin. Case Rep. 2022 7 2321
  6. [92]World Health Organisation Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach World Health Organization Geneva, Switzerland 2021 Available online: https://www.ncbi.nlm.nih.gov/books/NBK572729/ (accessed on 3 January 2024) 34370423
  7. [126]Karbuz A. Arısoy E.S. Kaplan S.L. Pertussis in children Paediatric ENT Infections Springer Cham, Switzerland 2022 735 750
  8. [183]Penicillin G and V LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet] Updated 20 October 2020 National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, MD, USA 2012 Available online: https://www.ncbi.nlm.nih.gov/books/NBK547993/ (accessed on 7 January 2024) 31643176
  9. [209]Ma’ayeh S. Svärd S. Giardia and giardiasis Molecular Medical Microbiology Academic Press Cambridge, MA, USA 2024 3107 3119
  10. [247]Wagh P.K. Ahirrao S.P. Kshirsagar S.J. Gastroretentive drug delivery systems: A review on expandable system Indian J. Drugs 2018 6 142 151

Cited by

Sorted by citations

Authors
Rampedi, P. N., Ogunrombi, M. O., & Adeleke, O. A.
Affiliations
  • Sefako Makgatho Health Sciences University (ZA)
  • Dalhousie University (CA)
Corresponding author
Adeleke, Oluwatoyin A.
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2024-05-26
Volume
16
Issue
6
Pages
712
ISSN
1999-4923 (ISSN-L)
OpenAlex
W4399042646
Cited by
15
References
256
Citations by year
2026: 5 · 2025: 9 · 2024: 1
FWCI
1.77
Type
journal article
Language
en
Open access
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Research Foundation, South Africa (113143, D112-RDG, M053-MRC, R34000)
  • Department of Higher Education and Training, South Africa (113143, D112-RDG, M053-MRC, R34000)
  • South African Medical Research Council (113143, D112-RDG, M053-MRC, R34000)
  • Faculty of Health and College of Pharmacy, Dalhousie University, Canada (113143, D112-RDG, M053-MRC, R34000)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
pediatric infection, oral drug delivery, pediatric formulations, orally disintegrating tablets, multiparticulate dosage forms, chewable tablets, gastroretentive drug delivery, nanoparticle drug delivery, lipid nanoparticles, polymeric nanoparticles, bioavailability, medication adherence, dose accuracy, palatability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review