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Cited by 62Antibiotics Pharmacokinetics and EfficacyPharmacogenetics and Drug MetabolismPharmacovigilance and Adverse Drug Reactions

The DOI matches its Crossref record; 361 of the 361 references it cites were found in a registry or an index.

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

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Bolhuis, Mathieu S., Panday, Prashant N., Pranger, Arianna D., Kosterink, Jos G. W., Alffenaar, Jan-Willem C.·2011·Pharmaceutics
DOI 10.3390/pharmaceutics3040865PMC PMC3857062
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Abstract

Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.

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Crossref · 10.3390/pharmaceutics3040865

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Figure 1. Scope of the review and summary of the experimental section. The gray area symbolizes the focus of this review, i.e., pharmacokinetic (PK) drug interactions of antimicrobial drugs. Arrows symbolize a PK interaction. Upwards pointing arrows (↑): interaction affecting antimicrobial drug (§3.x.1 “Antimicrobial drugs as victims”). Downwards pointing arrows (↓): interaction affecting co-prescribed drug (§3.x.2 “Antimicrobial drugs as perpetrators”).
Figure 1. Scope of the review and summary of the experimental section. The gray area symbolizes the focus of this review, i.e., pharmacokinetic (PK) drug interactions of antimicrobial drugs. Arrows symbolize a PK interaction. Upwards pointing arrows (↑): interaction affecting antimicrobial drug (§3.x.1 “Antimicrobial drugs as victims”). Downwards pointing arrows (↓): interaction affecting co-prescribed drug (§3.x.2 “Antimicrobial drugs as perpetrators”).CC BY · PubMed Central

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Research works printed but not linked: 1

  1. Stockley, I. (2011). Stockley's Drug Interactions, Pharmaceutical Press. [6th ed.].

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Metadata

Authors
Bolhuis, M. S., Panday, P. N., Pranger, A. D., Kosterink, J. G. W., & Alffenaar, J.-W. C.
Affiliations
  • University Medical Center Groningen (NL)
  • Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
Corresponding author
Bolhuis, Mathieu S.
ORCID
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2011-11-18
Volume
3
Issue
4
Pages
865-913
ISSN
1999-4923 (ISSN-L)
DOI
10.3390/pharmaceutics3040865
PMC
PMC3857062
OpenAlex
W2151599229
Cited by
62
References
361
Citations by year
2026: 4 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 5 · 2015: 2 · 2014: 3
FWCI
0.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Keywords
pharmacokinetic interactions, antimicrobial agents, oxazolidinones, macrolides, fluoroquinolones, beta-lactam antibiotics, food-drug interactions, drug-drug interactions, interaction mechanisms, drug efficacy and toxicity

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