The DOI matches its Crossref record; 361 of the 361 references it cites were found in a registry or an index.
Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams
Open accessAbstract
Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It should be noted that ciprofloxacin is metabolized in the liver and can directly inhibit CYP1A2, CYP2D6, and CYP3A4 (Bolhuis et al., 2011).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Bolhuis et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation
Lau, W. C., Waskell, L. A., Watkins, P. B., Neer, C. J., Horowitz, K., Hopp, A. S., Tait, A. R., Carville, D. G. M., Guyer, K. E., & Bates, E. (2003) · Circulation · doi:10.1161/01.cir.0000047060.60595.cc · Cited by 686
Inactivation of Digoxin by the Gut Flora: Reversal by Antibiotic Therapy
Lindenbaum, J., Rund, D. G., Butler, V. P., Tse-Eng, D., & Saha, J. R. (1981) · New England Journal of Medicine · doi:10.1056/nejm198110013051403 · Cited by 423
A potentially hazardous interaction between erythromycin and midazolam
Olkkola, K. T., Aranko, K., Luurila, H., Hiller, A., Saarnivaara, L., Himberg, J., & Neuvonen, P. J. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.25 · Cited by 351
Kantola, T., Kivistö, K. T., & Neuvonen, P. J. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90151-5 · Cited by 285
Westphal, K. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.109797 · Cited by 285
Backman, J. T., Kivistö, K. T., Olkkola, K. T., & Neuvonen, P. J. (1998) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050420 · Cited by 266
Jacobson, T. A. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.07.080 · Cited by 243
Rifampin drastically reduces plasma concentrations and effects of oral midazolam
Backman, J. T., Olkkola, K. T., & Neuvonen, P. J. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90018-1 · Cited by 242
López-Cortés, L. F., Ruiz-Valderas, R., Viciana, P., Alarc??n-Gonz??lez, A., G??mez-Mateos, J., Jiménez, E. M. L., Sarasa-Nacenta, M., L??pez-Pua, Y., & Pach??n, J. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241090-00004 · Cited by 227
The effect of rifampin administration on the disposition of fexofenadine
Hamman, M. A. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113697 · Cited by 204
Research works printed but not linked: 1
- Stockley, I. (2011). Stockley's Drug Interactions, Pharmaceutical Press. [6th ed.].
Cited by
Sorted by citations
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319
Metadata
- Authors
- Bolhuis, M. S., Panday, P. N., Pranger, A. D., Kosterink, J. G. W., & Alffenaar, J.-W. C.
- Affiliations
- University Medical Center Groningen (NL)
- Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
- Corresponding author
- Bolhuis, Mathieu S.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2011-11-18
- Volume
- 3
- Issue
- 4
- Pages
- 865-913
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC3857062
- OpenAlex
- W2151599229
- Cited by
- 62
- References
- 361
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 5 · 2015: 2 · 2014: 3
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- pharmacokinetic interactions, antimicrobial agents, oxazolidinones, macrolides, fluoroquinolones, beta-lactam antibiotics, food-drug interactions, drug-drug interactions, interaction mechanisms, drug efficacy and toxicity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
