Baicalein 5,6-Dimethyl Ether Prevents Memory Deficits in the Scopolamine Zebrafish Model by Regulating Cholinergic and Antioxidant Systems
Open accessAbstract
Baicalein 5,6-dimethyl ether, a bioactive flavonoid isolated for the first time from Alnus rugosa, was explored for its capability to relieve memory deficits and decrease oxidative stress. We examined the neuropharmacological effects of baicalein 5,6-dimethyl ether on scopolamine (Sco)-induced zebrafish (Danio rerio) anxiety, amnesia, and brain oxidative stress and attempted to elucidate the underlying mechanisms. Anxiety-like behavior, exploratory behavior, and memory performance were measured using novel tank-diving test (NTT), Y-maze, and novel object recognition (NOR) tests. For 10 days, baicalein 5,6-dimethyl ether (1, 3, and 5 µg/L) was administered through immersion, whereas Sco (100 μM) was delivered 30 min before behavioral tests. Treatment with baicalein 5,6-dimethyl ether reduced anxiety and memory impairment, and increased exploratory behavior in specific tests, along with significant protection from neuronal oxidative stress in the brain tissue of Sco-treated zebrafish. Antioxidant and anti-acetylcholinesterase (AChE) activities of baicalein 5,6-dimethyl ether in the Sco-induced zebrafish were further confirmed using in vivo assays. In Sco-treated zebrafish, baicalein 5,6-dimethyl ether regulated cholinergic function by inhibiting AChE activity. Baicalein 5,6-dimethyl ether may be a promising candidate compound for treating anxiety and amnesia by restoring cholinergic activity and reducing brain oxidative stress, according to our findings.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Extracts from Nepeta nuda, Indigofera sessiliflora, Dendropanax morbifera, Pinus densiflora, Dichrocephala integrifolia, Alnus rugosa, Salvia moorcroftiana, and Sanguisorba minor reduced AChE activity and enhanced cognitive function in scopolamine-induced memory impairment models.
“Other studies on plant extracts like Nepeta nuda, Indigofera sessiliflora, Dendropanax morbifera, Pinus densiflora, Dichrocephala integrifolia, Alnus rugosa, Salvia moorcroftiana, and Sanguisorba minor have similarly reported reduced AChE activity and enhanced cognitive function in SCO-induced memory impairment models [40,41,42,43,44,45,46,47].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [47]
For Alnus rugosa, the Introduction reports that a stem methanolic extract had anticholinesterase activity. The Results and Conclusions report reduced AChE activity and improved memory in scopolamine-treated zebrafish, but those experiments tested baicalein 5,6-dimethyl ether isolated from A. rugosa, not the extract. This source therefore does not establish both claimed effects for the extract. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482 · see citing works
Colorimetric assay of catalase
Sinha, A. K. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90132-7 · Cited by 5,574 · see citing works
The zebrafish reference genome sequence and its relationship to the human genome.
Howe, K., Clark, M. D., Torroja, C. F., Torrance, J., Berthelot, C., Muffato, M., Collins, J. E., Humphray, S., McLaren, K., Matthews, L., et al. (2013) · Nature · doi:10.1038/nature12111 · Cited by 5,100 · see citing works
Age-related changes in oxidized proteins.
Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works
The estimation of red cell superoxide dismutase activity.
Winterbourn, C. C., Hawkins, R. E., Brian, M. N., & Carrell, R. W. (1975) · PubMed · Cited by 1,041 · see citing works
Li‐Weber, M. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.09.005 · Cited by 900 · see citing works
Anxiolytic effects of nicotine in zebrafish
Levin, E. D., Bencan, Z., & Cerutti, D. T. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.026 · Cited by 625 · see citing works
Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
Dinda, B., Dinda, S., DasSharma, S., Banik, R., Chakraborty, A., & Dinda, M. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.004 · Cited by 545 · see citing works
In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds
Chen, F., Chan, K. H., Jiang, Y., Kao, R. Y. T., Lü, H., Fan, K. W., Cheng, V. C., Tsui, W., Hung, I. F., & Lee, T. S. W. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.03.003 · Cited by 535 · see citing works
Baicalin, a metabolite of baicalein with antiviral activity against dengue virus
Moghaddam, E., Teoh, B., Sam, S., Lani, R., Hassandarvish, P., Chik, Z., Yueh, A., AbuBakar, S., & Zandi, K. (2014) · Scientific Reports · doi:10.1038/srep05452 · Cited by 281 · see citing works
Baicalein and 12/15-Lipoxygenase in the Ischemic Brain
van Leyen, K., Kim, H. Y., Lee, S., Jin, G., Arai, K., & Lo, E. H. (2006) · Stroke · doi:10.1161/01.str.0000249004.25444.a5 · Cited by 251 · see citing works
Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish
Richetti, S. K., Blank, M., Capiotti, K. M., Piato, Â., Bogo, M. R., Vianna, M. R. M. R., & Bonan, C. D. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.027 · Cited by 248 · see citing works
The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review
Liang, W., Huang, X., & Chen, W. (2017) · Aging and Disease · doi:10.14336/ad.2017.0829 · Cited by 246 · see citing works
Cognato, G. D. P., Bortolotto, J. W., Blazina, A. R., Christoff, R. R., Lara, D. R., Vianna, M. R. M. R., & Bonan, C. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.09.008 · Cited by 206 · see citing works
Mu, X. L., He, G., Cheng, Y., Li, X., Xu, B., & Du, G. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.03.008 · Cited by 194 · see citing works
Clemente, D., Porteros, Á., Weruaga, E., Alonso, J. R., Arenzana, F. J., Aijón, J., & Arévalo, R. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20111 · Cited by 161 · see citing works
Anti-HIV Activity of Medicinal Herbs: Usage and Potential Development
Wu, J. A., Attele, A. S., Zhang, L., & Yuan, C. (2001) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x01000083 · Cited by 158 · see citing works
Li, Q., Li, Q.-Q., Jia, J.-N., Sun, Q., Zhou, H., Jin, W., & Mao, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00638 · Cited by 154 · see citing works
Baicalein as a potent neuroprotective agent: A review
Sowndhararajan, K., Deepa, P., Kim, M.-J., Park, S. J., & Kim, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.135 · Cited by 152 · see citing works
Protein carbonylation: avoiding pitfalls in the 2,4-dinitrophenylhydrazine assay
Luo, S., & Wehr, N. B. (2009) · Redox Report · doi:10.1179/135100009x392601 · Cited by 116 · see citing works
Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease
Li, Y., Zhao, J., & Hölscher, C. (2017) · CNS Drugs · doi:10.1007/s40263-017-0451-y · Cited by 115 · see citing works
Establishing zebrafish as a model to study the anxiolytic effects of scopolamine
Hamilton, T. J., Morrill, A., Lucas, K., Gallup, J., Harris, M. L., Healey, M., Pitman, T., Schalomon, M., Digweed, S. M., & Tresguerres, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-15374-w · Cited by 114 · see citing works
de Carvalho, R. S. M., Duarte, F. S., & de Lima, T. C. M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.038 · Cited by 104 · see citing works
Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice
Liao, J., Hung, W.-Y., & Chen, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01422-5 · Cited by 104 · see citing works
Baicalein and baicalin as Zika virus inhibitors
Oo, A., Teoh, B., Sam, S., AbuBakar, S., & Zandi, K. (2018) · Archives of Virology · doi:10.1007/s00705-018-4083-4 · Cited by 104 · see citing works
Bioactive constituents and medicinal importance of genus Alnus
Sati, S. C., Sati, O., & Sati, N. (2011) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.91115 · Cited by 102 · see citing works
Scopolamine-induced learning impairment reversed by physostigmine in zebrafish
Kim, Y., Lee, Y., Kim, D., Jung, M. W., & Lee, C. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.003 · Cited by 100 · see citing works
Janjušević, L., Karaman, M. A., Šibul, F. S., Tommonaro, G., Iodice, C., Jakovljević, D. M., & Pejin, B. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1252759 · Cited by 91 · see citing works
Yuan, Y. J., Men, W., Shan, X., Zhai, H., Qiao, X., Geng, L., & Li, C. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00714-6 · Cited by 87 · see citing works
Inhibitory effects of baicalein against herpes simplex virus type 1
Luo, Z., Kuang, X., Zhou, Q., Yan, C., Li, W., Gong, H., Kurihara, H., Li, W., Li, Y., & He, R. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.06.008 · Cited by 86 · see citing works
Glutathione peroxidase activity in tissues of vitamin E-deficient mice.
Fukuzawa, K., & TOKUMURAI, A. (1976) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.22.405 · Cited by 84 · see citing works
Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection
Oo, A., Rausalu, K., Merits, A., Higgs, S., Vanlandingham, D. L., AbuBakar, S., & Zandi, K. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.12.012 · Cited by 80 · see citing works
Gaspary, K. V., Reolon, G. K., Gusso, D., & Bonan, C. D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.08.005 · Cited by 76 · see citing works
Smythe, J. W., Bhatnagar, S., Murphy, D., Timothy, C., & Costall, B. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00311-0 · Cited by 68 · see citing works
Gao, L., Li, J., Zhou, Y., Huang, X., Qin, X., & Du, G. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00074 · Cited by 59 · see citing works
Capatina, L., Boiangiu, R. Ş., Dumitru, G., Napoli, E., Ruberto, G., Hriţcu, L., & Todirașcu-Ciornea, E. (2020) · Antioxidants · doi:10.3390/antiox9010062 · Cited by 57 · see citing works
The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities
Ren, X., He, T., Chang, Y., Zhao, Y., Chen, X., Bai, S., Wang, L., Shen, M., & She, G. (2017) · Molecules · doi:10.3390/molecules22081383 · Cited by 56 · see citing works
Capatina, L., Todirașcu-Ciornea, E., Napoli, E., Ruberto, G., Hriţcu, L., & Dumitru, G. (2020) · Antioxidants · doi:10.3390/antiox9111083 · Cited by 56 · see citing works
Boiangiu, R. Ş., Mihăşan, M., Gorgan, L., Stache, A. B., & Hriţcu, L. (2021) · Antioxidants · doi:10.3390/antiox10020212 · Cited by 55 · see citing works
Effects of baicalein on β-amyloid peptide-(25–35)-induced amnesia in mice
Wang, S.-Y., Wang, H., Chi, C., Chen, C., & Liao, J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.10.029 · Cited by 54 · see citing works
Wei, N., Wei, Y., Li, B., & Pang, L. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2179-y · Cited by 52 · see citing works
Du, H., Chen, X., Zhang, L., Liu, Y., Zhan, C., Chen, J., Zhang, Y., Yu, Z., Zhang, J., Yang, H., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s211288 · Cited by 52 · see citing works
Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish (Danio rerio) Model
Brinza, I., Abd-Alkhalek, A. M., Raey, M. A. E., Boiangiu, R. Ş., Eldahshan, O. A., & Hriţcu, L. (2020) · Antioxidants · doi:10.3390/antiox9070580 · Cited by 51 · see citing works
Self-citationBaicalein improves behavioral dysfunction induced by Alzheimer’s disease in rats
Zhou, L., Tan, S., Shan, Y., Wang, Y., Cai, W., Huang, X., Liao, X.-Y., Li, H., Zhang, L., Zhang, B., et al. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s117469 · Cited by 46 · see citing works
Ayoub, I. M., Kořínek, M., Hwang, T., Chen, B., Chang, F., El‐Shazly, M., & Singab, A. N. B. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00476 · Cited by 46 · see citing works
Self-citationBaicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats
Qian, X., Wang, Z.-R., Zheng, J.-J., Ding, J., Zhong, J.-G., Zhang, T., Li, W. S., & Zhang, M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.02.028 · Cited by 46 · see citing works
Jin, J., Chen, Y., Wang, D., Ma, L., Guo, M., Zhou, C., & Dou, J. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-018-1022-6 · Cited by 39 · see citing works
Measuring recognition memory in zebrafish larvae: issues and limitations
Bruzzone, M., Gatto, E., Xiccato, T. L., Valle, L. D., Fontana, C. M., Meneghetti, G., & Bisazza, A. (2020) · PeerJ · doi:10.7717/peerj.8890 · Cited by 38 · see citing works
Rashed, K. N. Z., Ćirić, A., Glamočlija, J., Calhelha, R. C., Ferreira, I. C. F. R., & Sokóvić, M. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.05.017 · Cited by 36 · see citing works
Li, Y., Chen, Q., Ran, D., Wang, H., Du, W., Luo, Y., Jiang, W., Yang, Y., & Yang, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.019 · Cited by 36 · see citing works
Todd, K. J., Slatter, C. A. B., & Ali, D. W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00599.2003 · Cited by 35 · see citing works
Duan, D., Wang, K., Zhou, Y., Qin, X., Gao, L., & Du, G. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1919 · Cited by 31 · see citing works
Kim, K. C., Lee, I. K., Kang, K. A., Kim, H. S., Kang, S. S., & Hyun, J. W. (2012) · Cell Biology and Toxicology · doi:10.1007/s10565-012-9233-y · Cited by 30 · see citing works
Stefanello, F. V., Fontana, B. D., Ziani, P. R., Müller, T. E., Mezzomo, N. J., & Rosemberg, D. B. (2019) · Zebrafish · doi:10.1089/zeb.2018.1703 · Cited by 30 · see citing works
Kiyaseh, M., Andalib, S., Danafar, H., Rostamizadeh, K., & Sharafi, A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119546 · Cited by 29 · see citing works
Anxiolytic effects of an acetylcholinesterase inhibitor, physostigmine, in the adult zebrafish
Cho, H., Lee, C., Choi, J., Hwang, J., & Lee, Y. (2011) · Animal Cells and Systems · doi:10.1080/19768354.2011.642084 · Cited by 25 · see citing works
Conformational analysis of 5,6,7‐trisubstituted flavones: 13C NMR and molecular mechanics study
Biekofsky, R. R., Buschi, C. A., & Pomilio, A. B. (1991) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1260290606 · Cited by 23 · see citing works
Hughes, R. N., & Otto, M. T. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.009 · Cited by 22 · see citing works
Li, J., Zhou, Y., Du, G., Qin, X., & Gao, L. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172789 · Cited by 22 · see citing works
Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats
Wang, S., & Zhou, Y. (2018) · Translational Neuroscience · doi:10.1515/tnsci-2018-0015 · Cited by 20 · see citing works
Hsieh, Y., Hsieh, S., Chang, Y., Hsueh, C., & Hsu, S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707345 · Cited by 18 · see citing works
Yendapalli, P. R., David, D. C., & Balasundaram, A. (2019) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-019-0393-5 · Cited by 9 · see citing works
Rashed, K. N. Z., Sucupira, A. C. C., Neto, J. M. M., & Feitosa, C. M. (2013) · International Journal of Biomedical and Advance Research · doi:10.7439/ijbar.v4i9.456 · Cited by 4 · see citing works
Parker, R. H. (1992) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-22431-9_15 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 67 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Younis, M. M., Ayoub, I. M., Mostafa, N. M., Hassab, M. A. E., Eldehna, W. M., Al‐Rashood, S. T., & Eldahshan, O. A. (2022) · Plants · doi:10.3390/plants11070918 · Cited by 104 · see citing works
Self-citationZebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
Cueto‐Escobedo, J., Germán-Ponciano, L. J., Guillén-Ruiz, G., Soria-Fregozo, C., & Herrera-Huerta, E. V. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.795285 · Cited by 41 · see citing works
ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works
Li, J., Wang, Y., Wu, T., Li, S., Sun, Y., & Liu, Z. (2022) · Placenta · doi:10.1016/j.placenta.2022.02.013 · Cited by 30 · see citing works
Baicalein prevents stress-induced anxiety behaviors in zebrafish model
Selvaraj, L. K., Jeyabalan, S., Wong, L. S., Sekar, M., Logeshwari, B., Umamaheswari, S., Premkumar, S., Sekar, R. T., Begum, M. Y., Gan, S. H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.990799 · Cited by 27 · see citing works
Capatina, L., Napoli, E., Ruberto, G., & Hriţcu, L. (2021) · Molecules · doi:10.3390/molecules26237085 · Cited by 23 · see citing works
Brinza, I., Raey, M. A. E., El‐Kashak, W. A., Eldahshan, O. A., & Hriţcu, L. (2022) · Molecules · doi:10.3390/molecules27185901 · Cited by 22 · see citing works
Self-citationShi, J., Chen, J., Xie, X., Li, Y., Ye, W., Yao, J., Zhang, X., Zhang, T., & Gao, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1132857 · Cited by 22 · see citing works
Brinza, I., Boiangiu, R. Ş., Cioancă, O., Hăncianu, M., Dumitru, G., Hriţcu, L., Birsan, G.-C., & Todirașcu-Ciornea, E. (2023) · Antioxidants · doi:10.3390/antiox12081534 · Cited by 21 · see citing works
Self-citationThawkar, B. S., & Kaur, G. (2023) · Fish Physiology and Biochemistry · doi:10.1007/s10695-023-01185-6 · Cited by 16 · see citing works
Zebrafish models for studying cognitive enhancers
Kolesnikova, T. O., Demin, K. A., Costa, F. V., de Abreu, M. S., & Kalueff, A. V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105797 · Cited by 15 · see citing works
Therapeutic potential of baicalein against neurodegenerative diseases: An updated review
Siddiqui, N., Talib, M., Tripathi, P. N., Kumar, A., & Sharma, A. K. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100172 · Cited by 14 · see citing works
Brinza, I., Boiangiu, R. Ş., Mihăşan, M., Gorgan, L., Stache, A. B., Abd-Alkhalek, A. M., El‐Nashar, H. A. S., Ayoub, I. M., Mostafa, N. M., Eldahshan, O. A., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177013 · Cited by 16 · see citing works
Self-citationRuan, L., Guan, K., Wang, Y., Gu, M., Chen, Y., Cai, L., Ye, R., Huang, Z., Guo, A., Su, Z., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110689 · Cited by 12 · see citing works
Tajbakhsh, A., Hosseinpour-Soleimani, F., Abedi, M., Hashempur, M. H., & Negahdaripour, M. (2025) · Stroke · doi:10.1161/strokeaha.124.049048 · Cited by 13 · see citing works
Brinza, I., Boiangiu, R. Ş., Honceriu, I., Abd-Alkhalek, A. M., Osman, S. M., Eldahshan, O. A., Todirașcu-Ciornea, E., Dumitru, G., & Hriţcu, L. (2025) · Biomolecules · doi:10.3390/biom15010138 · Cited by 10 · see citing works
Self-citationAyoub, I. M., Eldahshan, O. A., Roxo, M., Zhang, S., Wink, M., & Singab, A. N. B. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400464 · Cited by 10 · see citing works
Self-citationYounis, M. M., Ayoub, I. M., George, M. Y., Mostafa, N. M., & Eldahshan, O. A. (2023) · Archiv der Pharmazie · doi:10.1002/ardp.202300438 · Cited by 9 · see citing works
Self-citationAbdelbaset, S., Ayoub, I. M., Mohamed, O. G., Tripathi, A., Eldahshan, O. A., & El‐Kersh, D. M. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04520-3 · Cited by 7 · see citing works
Self-citationWang, Q., Wang, Z., Li, Y., Wang, Q., Chen, Y., Xu, B., & Xu, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1659631 · Cited by 6 · see citing works
Poojari, A. S., Wairkar, S., & Kulkarni, Y. A. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05414-6 · Cited by 6 · see citing works
Brinza, I., Boiangiu, R. Ş., Honceriu, I., Abd-Alkhalek, A. M., Eldahshan, O. A., Dumitru, G., Hriţcu, L., & Todirașcu-Ciornea, E. (2024) · Plants · doi:10.3390/plants13121648 · Cited by 5 · see citing works
Self-citationSarup, P., Malik, J., & Pahuja, S. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004121 · Cited by 4 · see citing works
Logeshwari, B., Jeyabalan, S., Veeraraghavan, G., Krishnaraj, K., Ashok, C., Rajasekaran, N. K., Pandiyan, S. S., Siva, R., Subramaniyan, V., & Wong, L. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-13443-z · Cited by 4 · see citing works
Brinza, I., Boiangiu, R. Ş., Todirașcu-Ciornea, E., Hriţcu, L., & Dumitru, G. (2025) · Molecules · doi:10.3390/molecules30132858 · Cited by 4 · see citing works
Self-citationAbidar, S., Hriţcu, L., & Nhiri, M. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273309256240702053609 · Cited by 3 · see citing works
New Flavonoids of the Genus Scutellaria. II. Baicalein and Wogonin Glycosides from S. baicalensis
Olennikov, D. N., & Chirikova, N. K. (2024) · Chemistry of Natural Compounds · doi:10.1007/s10600-024-04294-7 · Cited by 2 · see citing works
Neuroprotection induced by baicalein and baicalin
Ashraf, H., Abdelkhalek, Y. M., El‐Shazly, M., Hriţcu, L., & Eldahshan, O. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00027-0 · Cited by 1 · see citing works
Self-citationAbdelbaset, S., Ayoub, I. M., Mohamed, O. G., Tripathi, A., Eldahshan, O. A., & El‐Kersh, D. M. (2024) · Figshare · doi:10.6084/m9.figshare.26043698
Self-citationAshaolu, T. J. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109400
- Authors
- Brinza, I., Ayoub, I. M., Eldahshan, O. A., & Hritcu, L.
- Affiliations
- Alexandru Ioan Cuza University (RO)
- Ain Shams University (EG)
- Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
- Corresponding author
- Eldahshan, Omayma A.
- Venue
- Plants
- Publisher
- MDPI AG
- Published
- 2021-06-18
- Volume
- 10
- Issue
- 6
- Pages
- 1245
- ISSN
- 2223-7747 (ISSN-L)
- PMC
- PMC8233988
- OpenAlex
- W3176016544
- Cited by
- 29
- References
- 67
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 1
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Plants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- This research was funded by the Doctoral School of Biology, Alexandru Ioan Cuza University of Iasi, Romania.
- Topics
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alnus rugosa, flavonoids, scopolamine-induced amnesia, memory impairment, anxiety-like behavior, oxidative stress, cholinergic system, acetylcholinesterase inhibition, antioxidant activity, zebrafish, novel object recognition, Y-maze, novel tank diving test
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
