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Cited by 102biodegradable polymer synthesis and propertiesBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications

Review of Hybrid Materials Based on Polyhydroxyalkanoates for Tissue Engineering Applications

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Pryadko, Artyom, Surmeneva, Maria A., Surmenev, Roman A.·2021·Polymers
DOI 10.3390/polym13111738PMC PMC8199458
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Abstract

This review is focused on hybrid polyhydroxyalkanoate-based (PHA) biomaterials with improved physico-mechanical, chemical, and piezoelectric properties and controlled biodegradation rate for applications in bone, cartilage, nerve and skin tissue engineering. PHAs are polyesters produced by a wide range of bacteria under unbalanced growth conditions. They are biodegradable, biocompatible, and piezoelectric polymers, which make them very attractive biomaterials for various biomedical applications. As naturally derived materials, PHAs have been used for multiple cell and tissue engineering applications; however, their widespread biomedical applications are limited due to their lack of toughness, elasticity, hydrophilicity and bioactivity. The chemical structure of PHAs allows them to combine with other polymers or inorganic materials to form hybrid composites with improved structural and functional properties. Their type (films, fibers, and 3D printed scaffolds) and properties can be tailored with fabrication methods and materials used as fillers. Here, we are aiming to fill in a gap in literature, revealing an up-to-date overview of ongoing research strategies that make use of PHAs as versatile and prospective biomaterials. In this work, a systematic and detailed review of works investigating PHA-based hybrid materials with tailored properties and performance for use in tissue engineering applications is carried out. A literature survey revealed that PHA-based composites have better performance for use in tissue regeneration applications than pure PHA.

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  • Recent studies have revealed the inherent piezoelectric properties of PHB, which show great potential to modulate cellular activity and thereby enhance bone tissue regeneration.

    “In addition, recent studies have revealed the inherent piezoelectric properties of PHB, which show great potential to modulate cellular activity and thereby enhance bone tissue regeneration [98].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [98]

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Cited by

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Authors
Pryadko, A., Surmeneva, M. A., & Surmenev, R. A.
Affiliations
  • Tomsk Polytechnic University (RU)
  • Physical Materials Science and Composite Materials Centre, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 30 Lenina Avenue, Tomsk 634050, Russia
ORCID
Venue
Polymers
Publisher
MDPI AG
Published
2021-05-26
Volume
13
Issue
11
Pages
1738
ISSN
2073-4360 (ISSN-L)
DOI
10.3390/polym13111738
PMC
PMC8199458
OpenAlex
W3165652640
Cited by
102
References
0
Citations by year
2026: 18 · 2025: 23 · 2024: 16 · 2023: 24 · 2022: 17 · 2021: 4
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Polymers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
polyhydroxyalkanoates, hybrid biomaterials, tissue engineering, biodegradable polymers, piezoelectric properties, biodegradation rate, bone tissue engineering, cartilage tissue engineering, neural tissue engineering, skin tissue engineering, polymer composites, 3D-printed scaffolds, tissue regeneration, bacterial biopolymers

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