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Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules
Open accessAbstract
Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and anesthetic medicine. In the last ten years, it has also been successfully investigated in the field of drug delivery, in the form of conjugates or hydrogel depot systems. HAylation, the covalent conjugation of HA to bioactive molecules, allows the overcoming of disadvantages associated with some pharmaceuticals, such as insolubility, instability and fast kidney clearance. These issues can be addressed also by covalent attachment of polyethylene glycol (PEGylation), but HA has the relevant advantages of biodegradability, high loading and specific targeting. In this review, the novel HA derivatives and the latest advances in HA-based drug delivery with a particular focus on the chemistry of conjugation will be discussed. Although, so far, there are no HA-drug conjugates on the market, several derivatives are presently under clinical investigation, and the promising results encourage further investigations and the exploitation of this versatile polysaccharide.
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Oh, E. J., Choi, J.-S., Kim, H., Joo, C.-K., & Hahn, S. K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.003 · Cited by 77
Cited by
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Abatangelo, G., Vindigni, V., Avruscio, G., Pandis, L., & Brun, P. (2020) · Cells · doi:10.3390/cells9071743 · Cited by 533
Crosslinking method of hyaluronic-based hydrogel for biomedical applications
Khunmanee, S., Jeong, Y., & Park, H. (2017) · Journal of Tissue Engineering · doi:10.1177/2041731417726464 · Cited by 438
Debele, T. A., Mekuria, S. L., & Tsai, H.-C. (2016) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.05.121 · Cited by 317
Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges
Tripodo, G., Trapani, A., Torre, M. L., Giammona, G., Trapani, G., & Mandracchia, D. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.032 · Cited by 286
Camacho, K. M., Kumar, S., Menegatti, S., Vogus, D. R., Anselmo, A. C., & Mitragotri, S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.04.031 · Cited by 97
Metadata
- Authors
- Mero, A., & Campisi, M.
- Venue
- Polymers
- Publisher
- MDPI AG
- Published
- 2014-01-30
- Volume
- 6
- Issue
- 2
- Pages
- 346-369
- ISSN
- 2073-4360 (ISSN-L)
- OpenAlex
- W2078206336
- Cited by
- 264
- References
- 1
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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