The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Mechanisms of Botulinum Toxin Type A Action on Pain
Open accessAbstract
Already a well-established treatment for different autonomic and movement disorders, the use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding. Currently, the only approved use of BoNT/A in relation to pain is the treatment of chronic migraines. However, controlled clinical studies show promising results in neuropathic and other chronic pain disorders. In comparison with other conventional and non-conventional analgesic drugs, the greatest advantages of BoNT/A use are its sustained effect after a single application and its safety. Its efficacy in certain therapy-resistant pain conditions is of special importance. Novel results in recent years has led to a better understanding of its actions, although further experimental and clinical research is warranted. Here, we summarize the effects contributing to these advantageous properties of BoNT/A in pain therapy, specific actions along the nociceptive pathway, consequences of its central activities, the molecular mechanisms of actions in neurons, and general pharmacokinetic parameters.
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Cites
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
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“The pharmacotherapeutic options for the treatment of chronic migraine and neuropathic pain are very limited, with certain antiepileptics and antidepressants [121,122], and the development of analgesics with novel mechanisms of action has proven to be extremely challenging [123].”
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Regulated Exocytosis Contributes to Protein Kinase C Potentiation of Vanilloid Receptor Activity
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Metadata
- Authors
- Matak, I., Bölcskei, K., Bach-Rojecky, L., & Helyes, Z.
- Venue
- Toxins
- Publisher
- MDPI AG
- Published
- 2019-08-05
- Volume
- 11
- Issue
- 8
- Pages
- 459
- ISSN
- 2072-6651 (ISSN-L)
- OpenAlex
- W2965226820
- Cited by
- 267
- References
- 91
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Matak, I., Bölcskei, K., Bach-Rojecky, L., & Helyes, Z. (2019). Mechanisms of Botulinum Toxin Type A Action on Pain. Toxins. https://doi.org/10.3390/toxins11080459
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
