The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution
Open accessAbstract
Venoms are one of the most convergent of animal traits known, and encompass a much greater taxonomic and functional diversity than is commonly appreciated. This knowledge gap limits the potential of venom as a model trait in evolutionary biology. Here, we summarize the taxonomic and functional diversity of animal venoms and relate this to what is known about venom system morphology, venom modulation, and venom pharmacology, with the aim of drawing attention to the importance of these largely neglected aspects of venom research. We find that animals have evolved venoms at least 101 independent times and that venoms play at least 11 distinct ecological roles in addition to predation, defense, and feeding. Comparisons of different venom systems suggest that morphology strongly influences how venoms achieve these functions, and hence is an important consideration for understanding the molecular evolution of venoms and their toxins. Our findings also highlight the need for more holistic studies of venom systems and the toxins they contain. Greater knowledge of behavior, morphology, and ecologically relevant toxin pharmacology will improve our understanding of the evolution of venoms and their toxins, and likely facilitate exploration of their potential as sources of molecular tools and therapeutic and agrochemical lead compounds.
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Cites
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The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms
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Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain
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A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid‐sensitive channel in sensory neurons
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Self-citationEvolution of separate predation- and defence-evoked venoms in carnivorous cone snails
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Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
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Cited by
Causes and Consequences of Snake Venom Variation
Casewell, N. R., Jackson, T. N. W., Laustsen, A. H., & Sunagar, K. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.05.006 · Cited by 396
Anti-fungal properties and mechanisms of melittin
Memariani, H., & Memariani, M. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10701-0 · Cited by 58
Metadata
- Authors
- Schendel, V., Rash, L. D., Jenner, R. A., & Undheim, E. A. B.
- Venue
- Toxins
- Publisher
- MDPI AG
- Published
- 2019-11-14
- Volume
- 11
- Issue
- 11
- Pages
- 666
- ISSN
- 2072-6651 (ISSN-L)
- OpenAlex
- W2987391632
- Cited by
- 285
- References
- 84
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schendel, V., Rash, L. D., Jenner, R. A., & Undheim, E. A. B. (2019). The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution. Toxins. https://doi.org/10.3390/toxins11110666
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
