The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy
Open accessAbstract
Staphylococcus aureus is an opportunistic pathogen and the leading cause of a wide range of severe clinical infections. The range of diseases reflects the diversity of virulence factors produced by this pathogen. To establish an infection in the host, S. aureus expresses an inclusive set of virulence factors such as toxins, enzymes, adhesins, and other surface proteins that allow the pathogen to survive under extreme conditions and are essential for the bacteria’s ability to spread through tissues. Expression and secretion of this array of toxins and enzymes are tightly controlled by a number of regulatory systems. S. aureus is also notorious for its ability to resist the arsenal of currently available antibiotics and dissemination of various multidrug-resistant S. aureus clones limits therapeutic options for a S. aureus infection. Recently, the development of anti-virulence therapeutics that neutralize S. aureus toxins or block the pathways that regulate toxin production has shown potential in thwarting the bacteria’s acquisition of antibiotic resistance. In this review, we provide insights into the regulation of S. aureus toxin production and potential anti-virulence strategies that target S. aureus toxins.
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Cites
Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457
Vandenesch, F., Lina, G., & Henry, T. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00012 · Cited by 405
CCR5 is a receptor for Staphylococcus aureus leukotoxin ED
Alonzo III, F., Kozhaya, L., Rawlings, S. A., Reyes-Robles, T., DuMont, A. L., Myszka, D. G., Landau, N. R., Unutmaz, D., & Torres, V. J. (2013) · Nature · doi:10.1038/nature11724 · Cited by 291
Corrigan, R. M., Miajlovic, H., & Foster, T. J. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-22 · Cited by 226
DuMont, A. L., Yoong, P., Day, C. J., Alonzo, F., McDonald, W. H., Jennings, M. P., & Torres, V. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305121110 · Cited by 216
Ragle, B. E., & Bubeck Wardenburg, J. (2009) · Infection and Immunity · doi:10.1128/iai.00115-09 · Cited by 202
Cited by
Fleitas Martínez, O., Cardoso, M. H., Ribeiro, S. M., & Franco, O. L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00074 · Cited by 304
The Complex Relationship between Virulence and Antibiotic Resistance
Schroeder, M., Brooks, B., & Brooks, A. (2017) · Genes · doi:10.3390/genes8010039 · Cited by 304
Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms
Touaitia, R., Mairi, A., Ibrahim, N. A., Basher, N. S., Idres, T., & Touati, A. (2025) · Antibiotics · doi:10.3390/antibiotics14050470 · Cited by 273
Metadata
- Authors
- Kong, C., Neoh, H.-M., & Nathan, S.
- Venue
- Toxins
- Publisher
- MDPI AG
- Published
- 2016-03-15
- Volume
- 8
- Issue
- 3
- Pages
- 72
- ISSN
- 2072-6651 (ISSN-L)
- OpenAlex
- W2300793209
- Cited by
- 317
- References
- 6
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- gold
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