The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa
Open accessAbstract
Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.
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“Beyond its role in giving the bacterium its distinct blueish–green colour”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [120]
In the citing paper
“Phenazines are highly diffusible toxic secondary metabolites, of which pyocyanin is the most well studied.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [120]
In the citing paper
“pyocyanin is a redox-active compound that generates reactive oxygen species, leading to oxidative stress in host cells120.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [120]
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“Pyocyanin has been shown to suppress ciliary function in respiratory epithelial cells”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [120]
In the citing paper
“and to affect host immune responses, interfering with immune signalling pathways, disrupting macrophage activity and inducing neutrophil apoptosis120,121.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [120]
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Cites
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378
Wilson, R., Sykes, D. A., Watson, D., Rutman, A., Taylor, G. W., & Cole, P. J. (1988) · Infection and Immunity · doi:10.1128/iai.56.9.2515-2517.1988 · Cited by 374
Cited by
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Jurado-Martín, I., Sainz-Mejías, M., & McClean, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063128 · Cited by 698
The Evolution and Ecology of Bacterial Warfare
Granato, E. T., Meiller-Legrand, T. A., & Foster, K. R. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.024 · Cited by 531
Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review
Tuon, F. F., Dantas, L. R., Suss, P. H., & Tasca Ribeiro, V. S. (2022) · Pathogens · doi:10.3390/pathogens11030300 · Cited by 422
Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections
Romeo, L., Iori, R., Rollin, P., Bramanti, P., & Mazzon, E. (2018) · Molecules · doi:10.3390/molecules23030624 · Cited by 230
Metadata
- Authors
- Hall, S., McDermott, C., Anoopkumar-Dukie, S., McFarland, A., Forbes, A., Perkins, A., Davey, A., Chess-Williams, R., Kiefel, M., Arora, D., & Grant, G.
- Venue
- Toxins
- Publisher
- MDPI AG
- Published
- 2016-08-09
- Volume
- 8
- Issue
- 8
- Pages
- 236
- ISSN
- 2072-6651 (ISSN-L)
- OpenAlex
- W2475881350
- Cited by
- 421
- References
- 2
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hall, S., McDermott, C., Anoopkumar-Dukie, S., McFarland, A., Forbes, A., Perkins, A., Davey, A., Chess-Williams, R., Kiefel, M., Arora, D., & Grant, G. (2016). Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa. Toxins. https://doi.org/10.3390/toxins8080236
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
