The DOI matches its Crossref record; 274 of the 274 references it cites were found in a registry or an index.
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Open accessAbstract
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing P. aeruginosa with the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors of P. aeruginosa and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very large P. aeruginosa genome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidating P. aeruginosa evolution and its interactions with the host throughout the course of infection.
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Cites
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PubChem Substance and Compound databases
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Cited by
Verdial, C., Serrano, I., Tavares, L., Gil, S., & Oliveira, M. (2023) · Biomedicines · doi:10.3390/biomedicines11041221 · Cited by 71
Lefebvre, D., Soscia, C., Schmitt, L., Goulet, A., Ize, B., & Bleves, S. (2025) · doi:10.64898/2025.12.24.696360
Lefebvre, D., Soscia, C., Schmitt, L., Goulet, A., Ize, B., & Bleves, S. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111416
Metadata
- Authors
- Jurado-Martín, I., Sainz-Mejías, M., & McClean, S.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-03-18
- Volume
- 22
- Issue
- 6
- Pages
- 3128
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3136759802
- Cited by
- 698
- References
- 274
- FWCI
- 27.44
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
