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Make Yourself at Home: Viral Hijacking of the PI3K/Akt Signaling Pathway
Open accessAbstract
As viruses do not possess genes encoding for proteins required for translation, energy metabolism or membrane biosynthesis, they are classified as obligatory intracellular parasites that depend on a host cell to replicate. This genome limitation forces them to gain control over cellular processes to ensure their successful propagation. A diverse spectrum of virally encoded proteins tackling a broad spectrum of cellular pathways during most steps of the viral life cycle ranging from the host cell entry to viral protein translation has evolved. Since the host cell PI3K/Akt signaling pathway plays a critical regulatory role in many cellular processes including RNA processing, translation, autophagy and apoptosis, many viruses, in widely varying ways, target it. This review focuses on a number of remarkable examples of viral strategies, which exploit the PI3K/Akt signaling pathway for effective viral replication.
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Cites
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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Phosphatidylinositol-3-OH kinase direct target of Ras
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The emerging mechanisms of isoform-specific PI3K signalling
Vanhaesebroeck, B., Guillermet-Guibert, J., Graupera, M., & Bilanges, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2882 · Cited by 1,767
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Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 346
The therapy of idiopathic pulmonary fibrosis: what is next?
Somogyi, V., Chaudhuri, N., Torrisi, S. E., Kahn, N., Müller, V., & Kreuter, M. (2019) · European Respiratory Review · doi:10.1183/16000617.0021-2019 · Cited by 265
Antiviral potential of curcumin
Mathew, D., & Hsu, W.-L. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.017 · Cited by 258
Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?
James, C., & Roberts, S. (2016) · Pathogens · doi:10.3390/pathogens5010008 · Cited by 83
Ikonomov, O. C., Sbrissa, D., Venkatareddy, M., Tisdale, E., Garg, P., & Shisheva, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.01.008 · Cited by 31
Metadata
- Authors
- Diehl, N., & Schaal, H.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2013-12-16
- Volume
- 5
- Issue
- 12
- Pages
- 3192-3212
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W2138355348
- Cited by
- 200
- References
- 7
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
