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Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis

Ikonomov, Ognian C., Sbrissa, Diego, Venkatareddy, Madhusudan, Tisdale, Ellen, Garg, Puneet, Shisheva, Assia·2015·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI 10.1016/j.bbamcr.2015.01.008PMC PMC4431544
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  • Approximately 60-70% of the PI(3)P pool is produced by the lipid kinase VPS34.

    “Approximately 60–70% of the PI(3)P pool is produced by the lipid kinase VPS34”

    From PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity (2025) · cites this paper as Ikonomov et al., 2015

    Results §3.4 reports that PtdIns3P fell to about 45% of control levels in Vps34-knockout podocytes. It also says the residual level was overestimated by roughly 20–25%, making a Vps34 contribution of approximately 60–70% plausible after correction. The estimate is supported for the podocytes studied, but the citing sentence presents it as an unqualified proportion of the PI(3)P pool. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • In mouse embryonic fibroblasts, approximately two-thirds of the PI(3)P pool is generated by the lipid kinase VPS34.

    “In mouse embryonic fibroblasts, approximately two-thirds of the PI(3)P pool is generated by the lipid kinase VPS34 (Devereaux et al., 2013; Ikonomov et al., 2015).”

    From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Ikonomov et al., 2015

    Results §3.4 reports that Vps34 knockout reduced PtdIns3P to about 45% of control levels, but those measurements were in podocytes, not mouse embryonic fibroblasts. Results §3.3 mentions Vps34-knockout fibroblasts only in connection with evidence for additional sources of localized PtdIns3P; it does not quantify their Vps34-generated pool. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 58

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Metadata

Authors
Ikonomov, O. C., Sbrissa, D., Venkatareddy, M., Tisdale, E., Garg, P., & Shisheva, A.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2015-05
Volume
1853
Issue
5
Pages
1240-1250
ISSN
0167-4889
DOI
10.1016/j.bbamcr.2015.01.008
PMC
PMC4431544
Cited by
31
References
2
Language
en
Licence
Funders
  • National Institutes of Health (DK58058, DK096053, DK097027, GM068813)
  • American Diabetes Association (BS-161)
  • Wayne State University
  • WSU School of Medicine Research Offices

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