The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
HBV DNA Integration: Molecular Mechanisms and Clinical Implications
Open accessAbstract
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in the host cell genome, despite this form being a replicative dead-end for the virus. The frequent finding of somatic integration of viral DNA suggests an evolutionary benefit for the virus; however, the mechanism of integration, its functions, and the clinical implications remain unknown. Here we review the current body of knowledge of HBV DNA integration, with particular focus on the molecular mechanisms and its clinical implications (including the possible consequences of replication-independent antigen expression and its possible role in hepatocellular carcinoma). HBV DNA integration is likely to influence HBV replication, persistence, and pathogenesis, and so deserves greater attention in future studies.
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Cites
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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
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Cited by
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification
(2021) · Advances in Cancer Research · doi:10.1016/bs.acr.2020.10.001 · Cited by 851
Chronic hepatitis B virus infection
Seto, W.-K., Lo, Y.-R., Pawlotsky, J.-M., & Yuen, M.-F. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31865-8 · Cited by 555
Immunobiology and pathogenesis of hepatitis B virus infection
Iannacone, M., & Guidotti, L. G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00549-4 · Cited by 520
Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma
D'souza, S., Lau, K. C., Coffin, C. S., & Patel, T. R. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i38.5759 · Cited by 257
Metadata
- Authors
- Tu, T., Budzinska, M., Shackel, N., & Urban, S.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2017-04-10
- Volume
- 9
- Issue
- 4
- Pages
- 75
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W2606276381
- Cited by
- 447
- References
- 92
- FWCI
- 20.59
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
