Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats
Open accessAbstract
High dose medetomidine 0.13 mg/kg can be used for semen collection in cats with variable results in terms of quantity and quality. Therefore, a variation in terms of distribution and elimination among patients has been hypothesised. The aim of the study was to characterise the pharmacokinetics of medetomidine (0.13 mg/kg) administered intramuscularly (IM) in healthy male cats. Eighteen male cats undergoing castration were included, and medetomidine (0.13 mg/kg) was administered IM. Venous blood samples were collected at 20, 30, 40, 50, 60, 75 and 90 minutes after medetomidine administration. Before orchiectomy, at T20, sperm collection was attempted. Plasma medetomidine concentrations were determined by liquid chromatography/mass spectrometry analysis. Semen collection was successful in 15/18 cats. The medetomidine plasma concentration following the IM administration of a bolus was best described using a non-compartment model. Time of maximum concentration was observed at 40 minutes (range 20–90); maximum concentration was 32.8 ng/mL (range 26.8–51.2). The median apparent clearance was 11.9 mL/kg/minute (range 0.7–43.8). In conclusion, medetomidine administered IM at 0.13 mg/kg reached its peak plasma concentration slowly and with variability among patients. In addition, it was characterised by low total body clearance probably due to the cardiovascular alterations associated with medetomidine administration.
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- Authors
- Romagnoli, N., Lambertini, C., Zambelli, D., Cunto, M., Ballotta, G., & Barbarossa, A.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Lambertini, Carlotta
- ORCID
- Venue
- Veterinary Sciences
- Publisher
- MDPI AG
- Published
- 2020-02-03
- Volume
- 7
- Issue
- 1
- Pages
- 17
- ISSN
- 2306-7381 (ISSN-L)
- PMC
- PMC7157624
- OpenAlex
- W3003947324
- Cited by
- 6
- References
- 28
- Citations by year
- 2023: 3 · 2022: 2 · 2020: 1
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Veterinary Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Keywords
- medetomidine, pharmacokinetics, cats, semen collection, intramuscular administration, plasma concentration, non-compartmental model, apparent clearance, time to peak concentration, male cats, castration, sperm collection, alpha-2 adrenergic agonists
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