Antioxidant & Antimicrobial Activities of Cocos Nucifera Linn. (Arecaceae) Endocarp Extracts
Open accessAbstract
Cocos nucifera (CN), commonly known as Coconut tree, is used for its several beneficial health effects as antitumor, anthelmintic, antidotal, antiseptic, aperients, aphrodisiac, astringent, bactericidal, depurative, diuretic, hemostat, pediculicide, refrigerant, stomachic,styptic, suppurative and vermifuge. Our objective was to determine the antioxidant activities, DPPH radical scavenging activities and antimicrobial activities of the ethanolic (cold percolation:RNM-01 & hot percolation:RNM02) extracts, dry distilled extract(RNDS) and aqueous extract(hot percolation: RNA) of endocarp of cocos nucifera from Karnataka region in India. Agar disc diffusion method was used for in vitro antibacterial and antifungal screening. The overall results provide promising baseline information for the potential use of the crude anti-oxidant extracts from CN in the treatment of bacterial and fungal infection as well as for the reduction of other human diseases. As it has been already reported that there is an inverse relationship between dietary-intake of antioxidant-rich foods and the incidence of a number of human diseases, therefore these results are interesting. © 2011 IGJPS. All rights reserved.
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Ethanolic (cold and hot percolation), dry-distilled, and aqueous extracts of endocarp had significant antioxidant activity (4.1828, 3.31, 20.83, 1.0179 μg/mL, respectively) comparable with that of standard ascorbic acid.
“The DPPH analysis demonstrated that ethanolic (cold and hot percolation), dry-distilled, and aqueous extracts of endocarp had significant antioxidant activity (4.1828, 3.31, 20.83, 1.0179 μg/mL, respectively) comparable with that of standard ascorbic acid (48).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [48]
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- After the DPPH radical scavenging analysis, All extracts RNM-01, RNM-02, RNA-01 and RNDS were found to be significant antioxidant activity 4.1828, 3.31, 20.83, 1.0179 μgmL-1 respectively comparable to standard ascorbic acid(Table 7). RNM-01 showed significant results after nitric oxide assay and alkaline DMSO method, activity was similar to that of the standard drug, ascorbic acid(Table 8). Indo Global Journal of Pharmaceutical Sciences, 2011; 1(4): 354-361 Crude methanolic extracts(RNM-01 & RNM-02) may contain thousands of compounds including flavones, proanthocyanidin and even soluble polysaccharide which might be responsible for the above activities. The antioxidant property of the phenolics mainly depends on the number and position of the hydroxyl group. The antioxidant property of the extracts were verified by the DPPH scavenging method. DPPH test confirms the radical scavenging potentiality of the endocarp extracts by measuring the inactivation potential of the radical in an aqueous medium. Free radical scavenging property of RNM-01 was further verified by the nitric oxide assay and alkaline DMSO method. Antimicrobial activity of the endocarp extracts shows strong activity against B. Subtilis, P. Aeruginosa, S. Aureus, M. Luteus. However, they shows no response against E. coli and clinical strains of bacterial and fungal microbes. In this respect further investigation is going on. To our knowledge, for the first time we have reported about the strong antioxidant and antimicrobial properties of the endocarp extracts of cocos nucifera. The endocarps of cocos nucifera are discarded as waste and it is considered as one of the major agro wastes of the tropical countries. Therefore our study will definitely open up a scope for future utilization of these agro wastes for therapeutic purposes.
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- Authors
- K Singla, R., Jaiswal, N., Bhat G, V., & Jagani, H.
- Affiliations
- Manipal Academy of Higher Education (IN)
- ORCID
- Jagani, Hitesh
- Venue
- Indo Global Journal of Pharmaceutical Sciences
- Published
- 2011
- Volume
- 01
- Issue
- 04
- Pages
- 354-361
- ISSN
- 2249-1023 (ISSN-L)
- OpenAlex
- W4292875810
- Cited by
- 16
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Indo Global Journal of Pharmaceutical Sciences (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Cocos nucifera, coconut endocarp, antioxidant activity, antimicrobial activity, DPPH radical scavenging, antibacterial activity, antifungal activity, plant extracts, medicinal plants
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