Effects of a Dental Gel Over 6 Months on Periodontal Health in Subjects with Stage II and III (Mild and Moderate) Periodontitis
Open accessAbstract
Objective: Overall aim of this prospective, randomized, positive controlled, double-blind in vivo study was to identify the effects of a test dental gel containing 2.6% edathamil with an added carrier and permeability enhancer vs. a positive control dentifrice on periodontal health measures in patients with Stage II and III periodontitis. Methods: In this prospective double-blinded, randomized study, 33 subjects were randomly assigned in a 1:1 ratio to brushing their teeth with either the test gel (LivFresh®, Livionex Dental Gel, Los Gatos, CA 95030) or the positive control toothpaste (Crest ProHealth®, P&G, Cincinnati, OH 45202).Full-mouth gingival index, modified sulcus bleeding index, and periodontal pocket probing depths were recorded for all teeth at baseline, and on days 90 and 180.Subjects brushed with the study material twice a day. Results: The test dental gel reduced gingival inflammation and bleeding, as well as periodontal pocket probing depths significantly more than a control dentifrice. Conclusions: In this pilot study in subjects with Stage II and III periodontitis, a test dental gel was found to improve gingival inflammation and bleeding, as well as periodontal pocket depths significantly better than a control dentifrice.
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Previous studies have demonstrated the efficacy of a new dental gel with EDTA in reducing oral plaque deposits, gingival inflammation, and probing depths with minimal patient-reported side effects or impact upon tooth surface microarchitecture and microhardness.
“previous studies have demonstrated the efficacy of a new dental gel with EDTA, in reducing oral plaque deposits, gingival inflammation, and probing depths with minimal patient-reported side effects or impact upon tooth surface microarchitecture and microhardness. 20-26”
From A randomized double-blind clinical trial evaluating comparative plaque and gingival health associated with commercially available stannous fluoride-containing dentifrices as compared to a sodium fluoride control dentifrice (2023) · cites this paper as [22]
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredPrevious investigations lacked comparison between multiple commercially-available dentifrices, including a direct comparison with other stannous fluoride formulations.
“A critique of previous investigations included a lack of comparison between multiple commercially-available dentifrices, including a direct comparison with other stannous fluoride formulations. 20-26”
From A randomized double-blind clinical trial evaluating comparative plaque and gingival health associated with commercially available stannous fluoride-containing dentifrices as compared to a sodium fluoride control dentifrice (2023) · cites this paper as [22]
The Discussion (page unavailable) describes earlier studies comparing the test gel with a positive-control dentifrice, which supports the narrower point that those comparisons used a single control. It does not explicitly critique previous investigations for lacking comparisons across multiple commercially available dentifrices or with other stannous fluoride formulations. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThe comparative efficacy of a similar dentifrice formulation without stannous fluoride in plaque and gingival inflammatory reduction is consistent across studies.
“While only one of these reports evaluates a formulation that includes stannous fluoride, 26 the comparative efficacy of a similar dentifrice formulation without stannous fluoride in plaque and gingival inflammatory reduction is consistent across studies. 20-26”
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Cites
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“It is estimated that up to 50–90% of adults are affected by gingivitis [5].”
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Plaque Removal and Gingival Health after Use of a Novel Dental Gel: A Clinical Study
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Flagged first, then by citations
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Cited by
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Kaur, M., Geurs, N. C., Cobb, C. M., Otomo‐Corgel, J., Takesh, T., Lee, J. H., Lam, T. M., Lin, K., Nguyen, A., Nguyen, B. L., et al. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0721 · Cited by 11 · see citing works
Self-citationTakesh, T., Goshtasbi, A., Lin, K., Yang, S. M., Wink, C., Geisinger, M. L., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0254 · Cited by 4 · see citing works
Geisinger, M. L., Geurs, N. C., Novy, B., Otomo‐Corgel, J., Cobb, C. M., Jacobsen, P. L., Takesh, T., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0675 · Cited by 3 · see citing works
Self-citation
- Authors
- M Cobb, C.
- Affiliations
- Professor Emeritus, Department of Periodontics, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
- Venue
- Journal of Dentistry and Oral Sciences
- Published
- 2019-11-18
- Volume
- 1
- Issue
- 3
- ISSN
- 2582-3736 (ISSN-L)
- PMC
- PMC6938303
- OpenAlex
- W2994923874
- Cited by
- 6
- References
- 5
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- et
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Dentistry and Oral Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Arnold and Mabel Beckman Foundation (LAMMP NIH/NIBIB P41EB05890, NIH/NIBIB R03EB014852.)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- dental gel, periodontitis, gingivitis, gingival bleeding, probing depth, toothpaste, gingival index, modified sulcus bleeding index, periodontal health, penetration enhancers
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