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Cited by 340Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.

Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy

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Desai, Brinda S., Monahan, Angela J., Carvey, Paul M., Hendey, Bill·2007·Cell Transplantation
DOI 10.3727/000000007783464731
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Abstract

The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system. Though the BBB is thought to be intact during neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD), recent evidence argues otherwise. Dysfunction of the BBB may be involved in disease progression, eliciting of peripheral immune response, and, most importantly, altered drug efficacy. In this review, we will give a brief overview of the BBB, its components, and their functions. We will critically evaluate the current literature in AD and PD BBB pathology resulting from insult, neuroinflammation, and neurodegeneration. Specifically, we will discuss alterations in tight junction, transport and endothelial cell surface proteins, and vascular density changes, all of which result in altered permeability. Finally, we will discuss the implications of BBB dysfunction in current and future therapeutics. Developing a better appreciation of BBB dysfunction in AD and PD may not only provide novel strategies in treatment, but will prove an interesting milestone in understanding neurodegenerative disease etiology and progression.

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Crossref · 10.3727/000000007783464731

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Research works printed but not linked: 14

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Metadata

Authors
Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B.
Affiliations
  • Department of Pharmacology, Rush University Medical Center, Chicago IL, USA
  • Rush University Medical Center (US)
Venue
Cell Transplantation
Publisher
SAGE Publications
Published
2007-03
Volume
16
Issue
3
Pages
285-299
ISSN
  • 0963-6897 (ISSN-L)
  • 1555-3892
DOI
10.3727/000000007783464731
OpenAlex
W2316522881
Cited by
339
References
117
Citations by year
2026: 13 · 2025: 14 · 2024: 28 · 2023: 31 · 2022: 23 · 2021: 33 · 2020: 37 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 18 · 2012: 8
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Transplantation (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (5r01ns045316-03, W81XWH-04-01-0365)
  • U.S. Public Health Service (012307)
  • National Institute of Allergy and Infectious Diseases (R01AI051619, R01AI51619)
  • National Institute of Neurological Disorders and Stroke (NS045316)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
blood-brain barrier, Alzheimer's disease, Parkinson's disease, BBB dysfunction, tight junctions, blood-brain barrier permeability, neuroinflammation, neurodegeneration, brain drug delivery, vessel density, neurodegenerative disease therapeutics
MeSH terms
Alzheimer Disease, Biological Transport, Blood-Brain Barrier, Humans, Parkinson Disease, Disease Progression

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