Healthy Bone Marrow Cells Reduce Progression of Kidney Failure Better than CKD Bone Marrow Cells in Rats with Established Chronic Kidney Disease
Open accessAbstract
Chronic kidney disease (CKD) is a major health care problem. New interventions to slow or prevent disease progression are urgently needed. We studied functional and structural effects of infusion of healthy and CKD bone marrow cells (BMCs) in a rat model of established CKD. CKD was induced by 5/6 nephrectomy (SNX) in Lewis rats, and disease progression was accelerated with l-NNA and 6% NaCl diet. Six weeks after SNX, CKD rats received healthy eGFP + BMCs, CKD eGFP + BMCs, or vehicle by single renal artery injection. Healthy BMCs were functionally effective 6 weeks after administration: glomerular filtration rate (GFR; inulin clearance) (0.48 ± 0.16 vs. 0.26 ± 0.14 ml/min/100 g) and effective renal plasma flow (RPF; PAH clearance) (1.6 ± 0.40 vs. 1.0 ± 0.62 ml/min/100 g) were higher in healthy BMC-versus vehicle-treated rats (both p < 0.05). Systolic blood pressure (SBP) and proteinuria were lower 5 weeks after treatment with healthy BMCs versus vehicle (SBP, 151 ± 13 vs. 186 ± 25 mmHg; proteinuria, 33 ± 20 vs. 59 ± 39 mg/day, both p < 0.05). Glomerular capillary density was increased, and less sclerosis was detected after healthy BMCs (both p < 0.05). Tubulointerstitial inflammation was also decreased after healthy BMCs. eGFP + cells were present in the glomeruli and peritubular capillaries of the remnant kidney in all BMC-treated rats. CKD BMCs also reduced SBP, proteinuria, glomerulosclerosis, and tubular atrophy versus vehicle in CKD rats. However, CKD BMC therapy was not functionally effective versus vehicle [GFR: 0.28 ± 0.09 vs. 0.26 ± 0.16 ml/min/100 g (NS), RPF: 1.15 ± 0.36 vs. 0.78 ± 0.44 ml/min/100 g (NS)], and failed to decrease tubulointerstitial inflammation and fibrosis. Single intrarenal injection of healthy BMCs in rats with established CKD slowed progression of the disease, associated with increased glomerular capillary density and less sclerosis, whereas injection of CKD BMCs was less effective.
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Release of inflammatory immune cells from the bone marrow contributes to the pathogenesis of hypertension and chronic kidney disease.
“and the release of these inflammatory immune cells from the bone marrow contributes to the pathogenesis of hypertension and CKD15,156,189.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [189]
Abnormal sympathetic drive to the bone marrow in hypertension and chronic kidney disease dramatically shifts the immune properties of haematopoietic cells to a pro-inflammatory state.
“Abnormal sympathetic drive to the bone marrow in hypertension and CKD dramatically shifts the immune properties of haematopoietic cells to a pro-inflammatory state”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [189]
The immune pathway of the brain-kidney axis involves input from the CNS and/or sympathetic nervous system to the bone marrow and effects of inflammatory cells released from the bone marrow on the kidney.
“Therefore, the immune pathway of the brain-kidney axis involves input from the CNS and/or SNS to the bone marrow and the effects of inflammatory cells released from the bone marrow on the kidney.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [189]
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Regulatory T Cells as a Novel Candidate for Cell-Based Therapy in Kidney Disease
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Indoxyl sulfate as a potential tubular function marker across kidney disease models
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Bridging the Gap: A Canadian Perspective on Translational Kidney Research
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Bone marrow cell therapy in hypertensive kidney disease
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- Authors
- Van Koppen, A., Joles, J. A., Bongartz, L. G., Van Den Brandt, J., Reichardt, H. M., Goldschmeding, R., Nguyen, T. Q., & Verhaar, M. C.
- Affiliations
- Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands
- University Medical Center Utrecht (NL)
- Department of Cellular and Molecular Immunology, University of Göttingen Medical School, Göttingen, Germany
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Verhaar, Marianne C.
- ORCID
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2012-10
- Volume
- 21
- Issue
- 10
- Pages
- 2299-2312
- ISSN
- 0963-6897 (ISSN-L)
- 1555-3892
- OpenAlex
- W2318903660
- Cited by
- 39
- References
- 55
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- Locations
- Cell Transplantation (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Funders
- Nierstichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (016.096.359)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- chronic kidney disease, bone marrow cells, cell therapy, kidney failure progression, 5/6 nephrectomy, glomerular filtration rate, renal plasma flow, proteinuria, blood pressure, glomerulosclerosis, tubulointerstitial inflammation, renal fibrosis, tubular atrophy, remnant kidney, rat model, L-NNA
- MeSH terms
- Animals, Blood Pressure, Bone Marrow Cells, Disease Models, Animal, Kidney Glomerulus, Male, Rats, Inbred Lew, Bone Marrow Transplantation, Disease Progression, Rats, Renal Insufficiency, Chronic
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