The DOI matches its Crossref record; 285 of the 285 references it cites were found in a registry or an index.
Electrical Stimulation and Motor Recovery
Open accessAbstract
In recent years, several investigators have successfully regenerated axons in animal spinal cords without locomotor recovery. One explanation is that the animals were not trained to use the regenerated connections. Intensive locomotor training improves walking recovery after spinal cord injury (SCI) in people, and >90% of people with incomplete SCI recover walking with training. Although the optimal timing, duration, intensity, and type of locomotor training are still controversial, many investigators have reported beneficial effects of training on locomotor function. The mechanisms by which training improves recovery are not clear, but an attractive theory is available. In 1949, Donald Hebb proposed a famous rule that has been paraphrased as “neurons that fire together, wire together.” This rule provided a theoretical basis for a widely accepted theory that homosynaptic and heterosynaptic activity facilitate synaptic formation and consolidation. In addition, the lumbar spinal cord has a locomotor center, called the central pattern generator (CPG), which can be activated nonspecifically with electrical stimulation or neurotransmitters to produce walking. The CPG is an obvious target to reconnect after SCI. Stimulating motor cortex, spinal cord, or peripheral nerves can modulate lumbar spinal cord excitability. Motor cortex stimulation causes long-term changes in spinal reflexes and synapses, increases sprouting of the corticospinal tract, and restores skilled forelimb function in rats. Long used to treat chronic pain, motor cortex stimuli modify lumbar spinal network excitability and improve lower extremity motor scores in humans. Similarly, epidural spinal cord stimulation has long been used to treat pain and spasticity. Subthreshold epidural stimulation reduces the threshold for locomotor activity. In 2011, Harkema et al. reported lumbosacral epidural stimulation restores motor control in chronic motor complete patients. Peripheral nerve or functional electrical stimulation (FES) has long been used to activate sacral nerves to treat bladder and pelvic dysfunction and to augment motor function. In theory, FES should facilitate synaptic formation and motor recovery after regenerative therapies. Upcoming clinical trials provide unique opportunities to test the theory.
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“The efficacy of electrical stimulation (Fig. 3(a)) in restoring sensory perception and motor functions has been shown in numerous studies [103], [104].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [104]
Citations
Cites
The Organization of Behavior; A Neuropsychological Theory.
Attneave, F., B., M., & Hebb, D. O. (1950) · The American Journal of Psychology · doi:10.2307/1418888 · Cited by 5,146
Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997 · cited 4×
“As Caporale and Dan (37) pointed out, the synaptic modification has critical windows of tens of milliseconds and involves homosynaptic and heterosynaptic mechanisms, including long-term potentiation (LTP) due to trains of activity, release of neurotransmitters such as serotonin, and neuromodulatory heterosynaptic inte…”
BackgroundInfluentialSynaptic assembly of the brain in the absence of neurotransmitter secretion.
Verhage, M., Maia, A., Plomp, J., Brussaard, A., Heeroma, J., Vermeer, H., Toonen, R., Hammer, R., van den Berg, T. K., Missler, M., et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,387
Flexion‐reflex of the limb, crossed extension‐reflex, and reflex stepping and standing
Sherrington, C. (1910) · The Journal of Physiology · doi:10.1113/jphysiol.1910.sp001362 · Cited by 1,336
Harkema, S., Gerasimenko, Y., Hodes, J., Burdick, J., Angeli, C., Chen, Y., Ferreira, C., Willhite, A., Rejc, E., Grossman, R. G., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60547-3 · Cited by 1,229
The intrinsic factors in the act of progression in the mammal.
Brown, T. G. (1911) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1911.0077 · Cited by 1,215
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Liu, K., Lü, Y., Lee, J. K., Samara, R. F., Willenberg, R., Sears‐Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2603 · Cited by 987
Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury
Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E. S., Havton, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.020 · Cited by 908
Evidence for a Spinal Central Pattern Generator in Humans a
Dimitrijevic, M. R., Gerasimenko, Y. P., & Pinter, M. M. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09062.x · Cited by 800
Angeli, C. A., Edgerton, V. R., Gerasimenko, Y. P., & Harkema, S. J. (2014) · Brain · doi:10.1093/brain/awu038 · Cited by 750 · cited 1×
“cral epidural stimulation restored lower extremity voluntary control in chronic motor complete patients (5,9,98,214,220).”
Background
Research works printed but not linked: 4
- GraupeD. KohnK. H. Functional electrical stimulation for ambulation by paraplegics: Twelve years of clinical observations and system studies, 1st ed. Malabar, FL: Krieger Pub. Co.; 1994.
- TaylorP. N. EwinsD. J. FoxB. GrundyD. SwainI. D. Limb blood flow, cardiac output and quadriceps muscle bulk following spinal cord injury and the effect of training for the Odstock functional electrical stimulation standing system. Paraplegia 31(5): 303–310; 1993.
- 10.1002/bjs.8944 · DOI
- WhitehurstT. K. McGivernJ. P. Spinal cord stimulation as a therapy for sexual dysfunction. US006862479B1. United States. U.S. Patent Office; 2005.
Cited by
Sorted by citations
Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review
Habibollahi, M., Jiang, D., Lancashire, H. T., & Demosthenous, A. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3430038 · Cited by 11
“3(a)) in restoring sensory perception and motor functions has been shown in numerous studies [103], [104].”
Metadata
- Authors
- Young, W.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Young, Wise
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2015-03
- Volume
- 24
- Issue
- 3
- Pages
- 429-446
- ISSN
- 0963-6897 (ISSN-L)
- 1555-3892
- OpenAlex
- W2011550232
- Cited by
- 76
- References
- 285
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Transplantation (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- electrical stimulation, motor recovery, spinal cord injury, locomotor training, central pattern generator, epidural spinal cord stimulation, motor cortex stimulation, functional electrical stimulation, synaptic plasticity, Hebbian learning, axon regeneration, corticospinal tract
- MeSH terms
- Animals, Electric Stimulation, Humans, Locomotion, Motor Cortex, Peripheral Nerves, Spinal Cord, Spinal Cord Injuries, Recovery of Function
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