Cited by 294Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsPhysical Activity and Health

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The effects of physical exercise on fatty liver disease.

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van der Windt, Dirk J., Sud, Vikas, Zhang, Hongji, Tsung, Allan, Huang, Hai·2018·Gene Expression

DOI 10.3727/105221617x15124844266408PMC PMC5954622

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Abstract

The increasing prevalence of obesity has made nonalcoholic fatty liver disease (NAFLD) the most common chronic liver disease. As a consequence, NAFLD and especially its inflammatory form nonalcoholic steatohepatitis (NASH) are the fastest increasing etiology of end-stage liver disease and hepatocellular carcinoma. Physical inactivity is related to the severity of fatty liver disease irrespective of body weight, supporting the hypothesis that increasing physical activity through exercise can improve fatty liver disease. This review summarizes the evidence for the effects of physical exercise on NAFLD and NASH. Several clinical trials have shown that both aerobic and resistance exercise reduce the hepatic fat content. From clinical and basic scientific studies, it is evident that exercise affects fatty liver disease through various pathways. Improved peripheral insulin resistance reduces the excess delivery of free fatty acids and glucose for free fatty acid synthesis to the liver. In the liver, exercise increases fatty acid oxidation, decreases fatty acid synthesis, and prevents mitochondrial and hepatocellular damage through a reduction of the release of damage-associated molecular patterns. In conclusion, physical exercise is a proven therapeutic strategy to improve fatty liver disease.

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Authors: van der Windt, D. J., Sud, V., Zhang, H., Tsung, A., & Huang, H.
Affiliations: Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
University of Pittsburgh Medical Center (US)
ORCID: Sud, Vikas
Zhang, Hongji
Tsung, Allan
Huang, Hai
Venue: Gene Expression
Publisher: Xia & He Publishing
Published: 2018-05-18
Volume: 18
Issue: 2
Pages: 89-101
ISSN: 1052-2166 (ISSN-L)
DOI: 10.3727/105221617x15124844266408
PMC: PMC5954622
OpenAlex: W2774108532
Cited by: 294
References: 114
Citations by year: 2026: 19 · 2025: 37 · 2024: 40 · 2023: 39 · 2022: 36 · 2021: 61 · 2020: 42 · 2019: 17 · 2018: 3
FWCI: 2.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Gene Expression (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA214865)
National Institute of Allergy and Infectious Diseases (T32AI074490)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: physical activity, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, aerobic exercise, resistance training, hepatic fat content, insulin resistance, fatty acid oxidation, mitochondrial damage, hepatocyte injury, damage-associated molecular patterns, obesity, end-stage liver disease, hepatocellular carcinoma
MeSH terms: Animals, Energy Metabolism, Exercise Therapy, Humans, Insulin, Lipid Metabolism, Non-alcoholic Fatty Liver Disease

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