The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Hepatitis C virus and type 2 diabetes
Open accessAbstract
This review focuses on the relationship between hepatitis C virus (HCV) infection and glucose metabolism derangements. Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). The direct effect of HCV on the insulin signaling has been analyzed in experimental models. Although currently available data should be considered as preliminary, HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response. IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the early and sustained virological response to interferon-alpha-based therapy. Thus, a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted, in order to improve the clinical management of chronic hepatitis C patients.
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Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
Wang, C.-S., Wang, S.-T., Yao, W.-J., Chang, T.-T., & Chou, P. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm061 · Cited by 166
Cited by
Managing diabetes in patients with chronic liver disease
Khan, R., Foster, G. R., & Chowdhury, T. A. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.07.2574 · Cited by 34
Metadata
- Authors
- Negro, F., & Alaei, M.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2009
- Volume
- 15
- Issue
- 13
- Pages
- 1537
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W2134312738
- Cited by
- 169
- References
- 4
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
