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Cited by 11Adrenal Hormones and DisordersGastrointestinal motility and disordersCardiovascular Syncope and Autonomic Disorders

Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms

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Quénéhervé, L., Drui, D., Blin, J., Péré, M., Coron, E., Barbara, G., Barbaro, M. R., Cariou, B. +3 more·2021·Scientific Reports
DOI 10.1038/s41598-021-87158-2PMC PMC8044180
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Abstract

Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association "Adrenals" (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI.

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  • In chronic adrenal insufficiency patients, 30% suffered frequent and incapacitating gut symptoms consistent with Rome IV criteria for IBS, and they had decreased quality of life.

    “A study of chronic adrenal insufficiency patients highlighted that 30% of the participants suffered frequent and incapacitating gut symptoms, consistent with the Rome IV criteria for IBS, and that they had a decreased quality of life (530).”

    From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [530]

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Authors
Quénéhervé, L., Drui, D., Blin, J., Péré, M., Coron, E., Barbara, G., Barbaro, M. R., Cariou, B., Neunlist, M., Masson, D., & Bach-Ngohou, K.
Affiliations
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Nantes (FR)
  • University of Bologna (IT)
  • Centre National de la Recherche Scientifique (FR)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-04-13
Volume
11
Issue
1
Pages
8077-8077
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-021-87158-2
PMC
PMC8044180
OpenAlex
W3154741289
Cited by
11
References
32
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Association Surrénales, France
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords
chronic adrenal insufficiency, gastrointestinal symptoms, irritable bowel syndrome, abdominal pain, quality of life, Addison's disease, secondary adrenal insufficiency, congenital adrenal hyperplasia, Rome IV criteria, functional bowel disorders
MeSH terms
Adrenal Insufficiency, Adult, Aged, Chronic Disease, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Abdominal Pain, Case-Control Studies, Irritable Bowel Syndrome

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