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Cited by 54

The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.

Excretion of biliary compounds during intrauterine life

Macias, Rocio IR, Marin, Jose JG, Serrano, Maria A·2009·World Journal of Gastroenterology
DOI 10.3748/wjg.15.817
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Abstract

In adults, the hepatobiliary system, together with the kidney, constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine, respectively. However, during intrauterine life the biliary route of excretion for cholephilic compounds, such as bile acids and biliary pigments, is very poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of detoxifying enzymes and specific transport systems at different locations of the placental barrier, such as the endothelial cells of chorionic vessels and trophoblast cells, this organ plays an important role in the hepatobiliary-like function during intrauterine life. The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother. This may result in oxidative stress and apoptosis, mainly in the placenta and fetal liver, which might affect normal fetal development and challenge the fate of the pregnancy. The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem.

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  1. Ganapathy V, Leibach FH 1995. Placental biogenic amines and their transporters. editor. Placental Toxicology CRC Press: Boca Raton, FL; 1995;161-174.

Cited by

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Metadata

Authors
Macias, R. I., Marin, J. J., & Serrano, M. A.
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2009
Volume
15
Issue
7
Pages
817
ISSN
1007-9327
DOI
10.3748/wjg.15.817
Cited by
54
References
151
Language
en

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