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Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation
Open accessAbstract
AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-kappaB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor kappaB (NF-kappaB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NF-kappaB activation in a dose- and strain-dependent manner. In contrast, NF-kappaB activation in response to challenge with tumor necrosis factor-alpha (TNF-alpha) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibition-positive bifidobacteria, LPS-induced inhibition of NF-kappaB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-alpha, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation.
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Metadata
- Authors
- Riedel, C. U.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Riedel, Christian U
- ORCID
- Riedel, Christian U
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2006
- Volume
- 12
- Issue
- 23
- Pages
- 3729
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4087466
- OpenAlex
- W1166213883
- Cited by
- 210
- References
- 57
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 15 · 2023: 8 · 2022: 16 · 2021: 18 · 2020: 16 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 3 · 2012: 13
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Bifidobacterium, probiotics, NF-κB activation, lipopolysaccharide, intestinal epithelial cells, HT-29 cells, anti-inflammatory activity, interleukin-8, TNF-α, cyclooxygenase-2, ICAM-1, chronic intestinal inflammation, strain-dependent effects
- MeSH terms
- Bifidobacterium, Dose-Response Relationship, Drug, Humans, Inflammation, Intestinal Mucosa, Lipopolysaccharides, RNA, Messenger, Tumor Necrosis Factor-alpha, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic, Interleukin-8, NF-kappa B, Genes, Reporter, Intercellular Adhesion Molecule-1, HT29 Cells, Probiotics, Cyclooxygenase 2
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