Comparison of PPIs and H2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia
Open accessAbstract
AIM: To compare efficacy of proton pump inhibitors (PPIs) with H(2)-receptor antagonists (H(2)RAs) plus prokinetics (Proks) for dysmotility-like symptoms in functional dyspepsia (FD). METHODS: Subjects were randomized to receive open-label treatment with either rabeprazole 10 mg od (n = 57) or famotidine 10 mg bid plus mosapride 5 mg tid (n = 57) for 4 wk. The primary efficacy endpoint was change (%) from baseline in total dysmotility-like dyspepsia symptom score. The secondary efficacy endpoint was patient satisfaction with treatment. RESULTS: The improvement in dysmotility-like dyspepsia symptom score on day 28 was significantly greater in the rabeprazole group (22.5% ± 29.2% of baseline) than the famotidine + mosapride group (53.2% ± 58.6% of baseline, P < 0.0001). The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status. Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine + mosapride group (87.7% vs 59.6%, P = 0.0012). Rabeprazole therapy was the only significant predictor of treatment response (P < 0.0001), defined as a total symptom score improvement ≥ 50%. CONCLUSION: PPI monotherapy improves dysmotility-like symptoms significantly better than H(2)RAs plus Proks, and should be the treatment of first choice for Japanese FD.
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Cites a retracted work: 10.1002/14651858.cd001960.pub3
MajorThe cited work was retracted on 2011-02-16 (notice 10.1002/14651858.cd001960.pub4), before this paper was published (2012). Its authors could have known.
Cited work 10.1002/14651858.cd001960.pub3 · retracted 2011-02-16 · notice 10.1002/14651858.cd001960.pub4 · this paper published 2012
Cites a retracted work: 10.1002/14651858.cd001960
MajorThe cited work was retracted on 2011-02-16 (notice 10.1002/14651858.cd001960.pub4), before this paper was published (2012). Its authors could have known.
Cited work 10.1002/14651858.cd001960 · retracted 2011-02-16 · notice 10.1002/14651858.cd001960.pub4 · this paper published 2012
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- Authors
- Sakaguchi, M.
- Corresponding author
- Sakaguchi, Masahiro
- ORCID
- Sakaguchi, Masahiro
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2012
- Volume
- 18
- Issue
- 13
- Pages
- 1517
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3319948
- OpenAlex
- W2135149483
- Semantic Scholar
- 084075a6816243e8acbab7167f3c82d5b297a2a5
- Cited by
- 20
- References
- 35
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 5
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- World Journal of Gastroenterology
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- functional dyspepsia, proton pump inhibitors, rabeprazole, H2 receptor antagonists, famotidine, prokinetic agents, mosapride, Helicobacter pylori, treatment satisfaction, predictors of treatment response, Japanese patients
- MeSH terms
- Adult, Aged, Anti-Ulcer Agents, Benzamides, Dyspepsia, Female, Gastrointestinal Agents, Histamine H2 Antagonists, Humans, Male, Middle Aged, Morpholines, Esophageal Motility Disorders, Famotidine, Helicobacter pylori, Helicobacter Infections, Patient Satisfaction, 2-Pyridinylmethylsulfinylbenzimidazoles, Proton Pump Inhibitors, Rabeprazole
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