Cited by 109Helicobacter pylori-related gastroenterology studiesGastroesophageal reflux and treatmentsInflammatory mediators and NSAID effects

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Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies

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Ahn, Jeong Soo·2013·World Journal of Gastroenterology

DOI 10.3748/wjg.v19.i16.2560PMC PMC3646149

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Abstract

AIM: To evaluate the association between acid suppressive drug use and the development of gastric cancer. METHODS: A systematic search of relevant studies that were published through June 2012 was conducted using the MEDLINE (PubMed), EMBASE, and Cochrane Library databases. The search included observational studies on the use of histamine 2-receptor antagonists (H₂RAs) or proton pump inhibitors and the associated risk of gastric cancer, which was measured using the adjusted odds ratio (OR) or the relative risk and 95%CI. An independent extraction was performed by two of the authors, and a consensus was reached. RESULTS: Of 4595 screened articles, 11 observational studies (n = 94558) with 5980 gastric cancer patients were included in the final analyses. When all the studies were pooled, acid suppressive drug use was associated with an increased risk of gastric cancer risk (adjusted OR = 1.42; 95%CI: 1.29-1.56, I² = 48.9%, P = 0.034). The overall risk of gastric cancer increased among H₂RA users (adjusted OR = 1.40; 95%CI: 1.24-1.59, I² = 59.5%, P = 0.008) and PPI users (adjusted OR = 1.39; 95%CI: 1.19-1.64, I² = 0.0%, P = 0.377). CONCLUSION: Acid suppressive drugs are associated with an increased risk of gastric cancer. Further studies are needed to test the effect of acid suppressive drugs on gastric cancer.

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Authors: Ahn, J. S.
Affiliations: Seoul National University (KR)
Corresponding author: Ahn, Jeong Soo
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2013
Volume: 19
Issue: 16
Pages: 2560
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v19.i16.2560
PMC: PMC3646149
OpenAlex: W2056076454
Cited by: 109
References: 73
Citations by year: 2025: 6 · 2024: 6 · 2023: 5 · 2022: 13 · 2021: 9 · 2020: 14 · 2019: 11 · 2018: 13 · 2017: 14 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 2
FWCI: 1.00
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation
National Research Foundation of Korea
National Cancer Institute (R25CA087949)
Topics: Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: acid-suppressive drugs, gastric cancer, H2 receptor antagonists, proton pump inhibitors, gastric cancer risk, drug-induced cancer risk
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Female, Histamine H2 Antagonists, Humans, Male, Middle Aged, Risk Factors, Stomach Neoplasms, Odds Ratio, Risk Assessment, Proton Pump Inhibitors, Young Adult

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Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies

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