The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies
Open accessAbstract
AIM: To evaluate the association between acid suppressive drug use and the development of gastric cancer. METHODS: A systematic search of relevant studies that were published through June 2012 was conducted using the MEDLINE (PubMed), EMBASE, and Cochrane Library databases. The search included observational studies on the use of histamine 2-receptor antagonists (H₂RAs) or proton pump inhibitors and the associated risk of gastric cancer, which was measured using the adjusted odds ratio (OR) or the relative risk and 95%CI. An independent extraction was performed by two of the authors, and a consensus was reached. RESULTS: Of 4595 screened articles, 11 observational studies (n = 94558) with 5980 gastric cancer patients were included in the final analyses. When all the studies were pooled, acid suppressive drug use was associated with an increased risk of gastric cancer risk (adjusted OR = 1.42; 95%CI: 1.29-1.56, I² = 48.9%, P = 0.034). The overall risk of gastric cancer increased among H₂RA users (adjusted OR = 1.40; 95%CI: 1.24-1.59, I² = 59.5%, P = 0.008) and PPI users (adjusted OR = 1.39; 95%CI: 1.19-1.64, I² = 0.0%, P = 0.377). CONCLUSION: Acid suppressive drugs are associated with an increased risk of gastric cancer. Further studies are needed to test the effect of acid suppressive drugs on gastric cancer.
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“with some studies and meta-analyses reporting an increased risk of developing GC in long-term PPI users[62,63] up to 2.4 times greater, even after Helicobacter pylori (H. pylori) eradication, according to a recent study[64]”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [62]
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ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease
Katz, P. O., Dunbar, K. B., Schnoll‐Sussman, F. H., Greer, K. B., Yadlapati, R. H., & Spechler, S. J. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001538 · Cited by 1,064
for the SIF-AIGO-FIMMG Group, Scarpignato, C., on behalf of the Italian Society of Pharmacology, T. I. A. O. H. G., Gatta, L., Zullo, A., & Blandizzi, C. (2016) · BMC Medicine · doi:10.1186/s12916-016-0718-z · Cited by 469
“pylori-infected patients [448], where the antisecretory effect is increased • No controlled human data support the increased risk of gastric cancer [92, 449] • More and higher quality studies are needed to confirm or refute any causal link with gastric cancer [450, 451] • No data support the increased risk of colorect…”
ResultThe stomach in health and disease
Hunt, R. H., Camilleri, M., Crowe, S. E., El-Omar, E. M., Fox, J. G., Kuipers, E. J., Malfertheiner, P., McColl, K. E. L., Pritchard, D. M., Rugge, M., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307595 · Cited by 430
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258
Proton pump inhibitors: Risks of long‐term use
Eusebi, L. H., Rabitti, S., Artesiani, M. L., Gelli, D., Montagnani, M., Zagari, R. M., & Bazzoli, F. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13737 · Cited by 217
Metadata
- Authors
- Ahn, J. S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Ahn, Jeong Soo
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2013
- Volume
- 19
- Issue
- 16
- Pages
- 2560
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3646149
- OpenAlex
- W2056076454
- Cited by
- 109
- References
- 73
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 5 · 2022: 13 · 2021: 9 · 2020: 14 · 2019: 11 · 2018: 13 · 2017: 14 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea
- National Cancer Institute (R25CA087949)
- Topics
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- acid-suppressive drugs, gastric cancer, H2 receptor antagonists, proton pump inhibitors, gastric cancer risk, drug-induced cancer risk
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Histamine H2 Antagonists, Humans, Male, Middle Aged, Risk Factors, Stomach Neoplasms, Odds Ratio, Risk Assessment, Proton Pump Inhibitors, Young Adult
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