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Cited by 864

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

Open access
Petruzziello, Arnolfo, Marigliano, Samantha, Loquercio, Giovanna, Cozzolino, Anna, Cacciapuoti, Carmela·2016·World Journal of Gastroenterology
DOI 10.3748/wjg.v22.i34.7824
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Abstract

AIM: To review Hepatitis C virus (HCV) prevalence and genotypes distribution worldwide. METHODS: We conducted a systematic study which represents one of the most comprehensive effort to quantify global HCV epidemiology, using the best available published data between 2000 and 2015 from 138 countries (about 90% of the global population), grouped in 20 geographical areas (with the exclusion of Oceania), as defined by the Global Burden of Diseases project (GBD). Countries for which we were unable to obtain HCV genotype prevalence data were excluded from calculations of regional proportions, although their populations were included in the total population size of each region when generating regional genotype prevalence estimates. RESULTS: Total global HCV prevalence is estimated at 2.5% (177.5 million of HCV infected adults), ranging from 2.9% in Africa and 1.3% in Americas, with a global viraemic rate of 67% (118.9 million of HCV RNA positive cases), varying from 64.4% in Asia to 74.8% in Australasia. HCV genotype 1 is the most prevalent worldwide (49.1%), followed by genotype 3 (17.9%), 4 (16.8%) and 2 (11.0%). Genotypes 5 and 6 are responsible for the remaining < 5%. While genotypes 1 and 3 are common worldwide, the largest proportion of genotypes 4 and 5 is in lower-income countries. Although HCV genotypes 1 and 3 infections are the most prevalent globally (67.0% if considered together), other genotypes are found more commonly in lower-income countries where still account for a significant proportion of HCV cases. CONCLUSION: A more precise knowledge of HCV genotype distribution will be helpful to best inform national healthcare models to improve access to new treatments.

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Metadata

Authors
Petruzziello, A., Marigliano, S., Loquercio, G., Cozzolino, A., & Cacciapuoti, C.
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2016
Volume
22
Issue
34
Pages
7824
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.v22.i34.7824
OpenAlex
W2517875316
Cited by
864
References
52
FWCI
60.92
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. https://app.cochat.ai/papers/10.3748/wjg.v22.i34.7824
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Petruzziello, A., Marigliano, S., Loquercio, G., Cozzolino, A., & Cacciapuoti, C. (2016). Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World Journal of Gastroenterology. https://doi.org/10.3748/wjg.v22.i34.7824

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.