Cited by 442Gut microbiota and healthLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

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Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

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Zhou, Da, Pan, Qin, Xin, Feng-Zhi, Zhang, Rui-Nan, He, Chong-Xin, Chen, Guang-Yu, Liu, Chang, Chen, Yuan-Wen, Fan, Jian-Gao·2017·World Journal of Gastroenterology

DOI 10.3748/wjg.v23.i1.60PMC PMC5221287

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Abstract

AIM: To investigate whether gut microbiota metabolite sodium butyrate (NaB) is an effective substance for attenuating non-alcoholic fatty liver disease (NAFLD) and the internal mechanisms. METHODS: Male C57BL/6J mice were divided into three groups, normal control were fed standard chow and model group were fed a high-fat diet (HFD) for 16 wk, the intervention group were fed HFD for 16 wk and treated with NaB for 8 wk. Gut microbiota from each group were detected at baseline and at 16 wk, liver histology were evaluated and gastrointestinal barrier indicator such as zonula occluden-1 (ZO-1) were detected by immunohistochemistry and realtime-PCR, further serum or liver endotoxin were determined by ELISA and inflammation- or metabolism-associated genes were quantified by real-time PCR. RESULTS: . These bacteria can produce butyric acid in what seems like a virtuous circle. And butyrate restored HFD induced intestinal mucosa damage, increased the expression of ZO-1 in small intestine, further decreased the levels of gut endotoxin in serum and liver compared with HF group. Endotoxin-associated genes such as TLR4 and Myd88, pro-inflammation genes such as MCP-1, TNF-α, IL-1, IL-2, IL-6 and IFN-γ in liver or epididymal fat were obviously downregulated after NaB intervention. Liver inflammation and fat accumulation were ameliorated, the levels of TG and cholesterol in liver were decreased after NaB intervention, NAS score was significantly decreased, metabolic indices such as FBG and HOMA-IR and liver function indicators ALT and AST were improved compared with HF group. CONCLUSION: NaB may restore the dysbiosis of gut microbiota to attenuate steatohepatitis, which is suggested to be a potential gut microbiota modulator and therapeutic substance for NAFLD.

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Self-citation

Authors: Zhou, D., Pan, Q., Xin, F.-Z., Zhang, R.-N., He, C.-X., Chen, G.-Y., Liu, C., Chen, Y.-W., & Fan, J.-G.
Affiliations: Shanghai Jiao Tong University (CN)
ORCID: Zhou, Da
Pan, Qin
Zhang, Rui-Nan
Liu, Chang
Fan, Jian-Gao
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2017
Volume: 23
Issue: 1
Pages: 60
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v23.i1.60
PMC: PMC5221287
OpenAlex: W2571212804
Cited by: 441
References: 56
Citations by year: 2026: 34 · 2025: 61 · 2024: 66 · 2023: 58 · 2022: 68 · 2021: 46 · 2020: 50 · 2019: 30 · 2018: 17 · 2017: 11
FWCI: 12.17
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: sodium butyrate, non-alcoholic fatty liver disease, steatohepatitis, high-fat diet, gut microbiota, intestinal barrier, zonula occludens-1, endotoxin, gut-liver axis, gut dysbiosis, inflammation, insulin resistance, butyrate
MeSH terms: Gastrointestinal Microbiome, Animals, Drug Evaluation, Preclinical, Humans, Immunohistochemistry, Inflammation, Intestinal Mucosa, Lactobacillus, Liver, Liver Function Tests, Male, Mice, Inbred C57BL, Specific Pathogen-Free Organisms, Tumor Necrosis Factor-alpha, Cytokines, Butyric Acid, Mice, Diet, High-Fat, Real-Time Polymerase Chain Reaction, Zonula Occludens-1 Protein, Dysbiosis, Non-alcoholic Fatty Liver Disease

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Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

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