Quantification of Cytokine-Induced Cell Death in Human Colonic Organoids Using Live Fluorescence Microscopy

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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Plasma membrane changes during programmed cell deaths

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In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

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Morphological Features of Cell Death

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Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

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Cell death in the gut epithelium and implications for chronic inflammation

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Evaluation of synergism in drug combinations and reference models for future orientations in oncology

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Downregulation of epithelial apoptosis and barrier repair in active Crohn’s disease by tumour necrosis factor α antibody treatment

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Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

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Understanding synergy

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Synergistic effects of interferon γ and tumour necrosis factor α on T84 cell function

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Systems biology approaches for advancing the discovery of effective drug combinations

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The Anti-Cancer Activities of Vernonia amygdalina Extract in Human Breast Cancer Cell Lines Are Mediated through Caspase-Dependent and p53-Independent Pathways

Wong, F. C., Woo, C. C., Hsu, A., & Tan, B. K. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078021 · Cited by 108 · see citing works

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

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Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

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An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury

Matsuzawa, Y., Hine, A. M., Shono, Y., Rudensky, E., Lazrak, A., Yeung, F., Neil, J. A., Yao, X., Chen, Y.-H., Heaney, T., et al. (2020) · Blood · doi:10.1182/blood.2019004116 · Cited by 61 · see citing works

DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids

Flood, P. F., Fanning, A., Woznicki, J. A., Crowley, T., Christopher, A., Vaccaro, A., Houston, A. M., McSweeney, S. M., Ross, S. A., Hogan, A., et al. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00104.2022 · Cited by 56 · see citing works

Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues

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A Fast and Simple Fluorometric Method to Detect Cell Death in 3D Intestinal Organoids

Bode, K. J., Mueller, S., Schweinlin, M., Metzger, M., & Brunner, T. (2019) · BioTechniques · doi:10.2144/btn-2019-0023 · Cited by 47 · see citing works

Culture-Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

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Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids

Lee, C., Song, J. H., Cha, Y.-E., Chang, D. K., Kim, Y., & Hong, S. N. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac101 · Cited by 39 · see citing works

Human intestinal organoids: Modeling gastrointestinal physiology and immunopathology — current applications and limitations

Flood, P., Hanrahan, N., Nally, K., & Melgar, S. (2023) · European Journal of Immunology · doi:10.1002/eji.202250248 · Cited by 37 · see citing works

TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s Disease

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Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells

Woznicki, J. A., Flood, P. F., Bustamante-Garrido, M., Stamou, P., Moloney, G. M., Fanning, A., Zulquernain, S. A., McCarthy, J., Shanahan, F., Melgar, S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2263-0 · Cited by 32 · see citing works

Effect of Cell Seeding Density and Inflammatory Cytokines on Adipose Tissue-Derived Stem Cells: an in Vitro Study

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The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient–derived organoids

Lumibao, J. C., Okhovat, S. R., Peck, K. L., Lin, X., Lande, K., Yomtoubian, S., Ng, I., Tiriac, H., Lowy, A. M., Zou, J., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.172419 · Cited by 30 · see citing works

Less is More: Longer Exposure Times with Low Light Intensity is Less Photo-Toxic

Mubaid, F., & Brown, C. M. (2017) · Microscopy Today · doi:10.1017/s1551929517000980 · Cited by 28 · see citing works

Organoid Medicine for Inflammatory Bowel Disease

Wakisaka, Y., Sugimoto, S., & Sato, T. (2022) · Stem Cells · doi:10.1093/stmcls/sxab020 · Cited by 26 · see citing works

Density dependent regulation of inflammatory responses in macrophages

Vaughan-Jackson, A., Stodolak, S., Ebrahimi, K. H., Johnson, E., Reardon, P. K., Dupont, M., Zhang, S., McCullagh, J., & James, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.895488 · Cited by 19 · see citing works

Cell death mechanisms in sepsis-associated adaptive immune dysfunction

Li, X., Qian, W., Cao, N., & He, Y. (2026) · Journal of Critical Care · doi:10.1016/j.jcrc.2026.155696 · Cited by 1 · see citing works

Regulatory mechanisms and therapeutic targets of programmed cell death in intestinal epithelial cells in inflammatory bowel disease

Zhou, X., Wu, Z., Cai, L., Liu, M., & Lu, B. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103877

Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids

Pauer, S. M., Schindler, A., Ghezellou, P., Spengler, B., Diener, M., & Ballout, J. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1738447 · Cited by 1 · see citing works

Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology

Marchelletta, R. R., Yu, J., Moon, C., & Kim, M. M. (2019) · Current Protocols in Pharmacology · doi:10.1002/cpph.54 · Cited by 2 · see citing works

P046 Disease modelling of Inflammatory Bowel Disease by human colon organoids

Molnár, T., Jójárt, B., Resál, T., Szántó, K. J., Kata, D., Földesi, I., Molnár, T., Maléth, J., & Farkas, K. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab076.175 · Cited by 2 · see citing works

A Fast and Simple Fluorometric Method to Detect Cell Death in 3D Intestinal Organoids

Bode, K. J., Mueller, S., Schweinlin, M., Metzger, M., & Brunner, T. (2019) · BioTechniques · doi:10.2144/btn-2019-0023 · Cited by 47 · see citing works

DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids

Flood, P. F., Fanning, A., Woznicki, J. A., Crowley, T., Christopher, A., Vaccaro, A., Houston, A. M., McSweeney, S. M., Ross, S. A., Hogan, A., et al. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00104.2022 · Cited by 56 · see citing works