Autologous Platelet-Rich Plasma: A Revolution in Soft Tissue Sports Injury Management?
Abstract
Platelet-rich plasma (PRP) therapy is an emerging technology that aims to improve the process of tissue repair through local delivery of autologous bioactive agents to influence critical physiological mechanisms such as inflammation, angiogenesis, or extracellular matrix synthesis. These biological properties have prompted the therapeutic administration of PRP in orthopedics and sports medicine. Given its biocompatibility and healing properties, percutaneous injections of PRP are used in athletes to treat tendon and muscle injuries. Studies of varying levels of evidence have demonstrated the safety and beneficial effects of PRP in these applications, but standardization of the methods of plasma preparation and procedures for application is necessary for further advancements. Continued efforts to identify factors that influence the biological response to PRP treatment may yield new formulations tailored to each specific application. The growing emphasis on an evidence-based approach in the sports medicine setting demands additional research efforts before incorporating this technology in routine clinical care.
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PRP efficacy in Achilles tendinopathy and knee osteoarthritis has yielded mixed results, with some trials reporting no significant benefit over placebo.
“PRP’s efficacy in Achilles tendinopathy and knee osteoarthritis has yielded mixed results, with some trials reporting no significant benefit over placebo, underscoring the lack of standardization in PRP preparation [13,95,96].”
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- Authors
- Mei-Dan, O., Lippi, G., Sánchez, M., Andia, I., & Maffulli, N.
- Affiliations
- Meir Medical Center (IL)
- University of Parma (IT)
- Mile End Hospital (GB)
- Queen Mary University of London (GB)
- Corresponding author
- Maffulli, Nicola
- Venue
- The Physician and Sportsmedicine
- Publisher
- Informa UK Limited
- Published
- 2010-12
- Volume
- 38
- Issue
- 4
- Pages
- 127-135
- ISSN
- 0091-3847 (ISSN-L)
- 2326-3660
- OpenAlex
- W2056229158
- Cited by
- 83
- References
- 52
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Physician and Sportsmedicine (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports injuries and prevention
- Keywords
- platelet-rich plasma, autologous PRP, sports injuries, soft tissue injury, tendon injury, muscle damage, tissue repair, inflammation, angiogenesis, extracellular matrix synthesis, PRP preparation standardization, percutaneous injection, athletes
- MeSH terms
- Athletic Injuries, Humans, Transplantation, Autologous, Wound Healing, Soft Tissue Injuries, Platelet-Rich Plasma
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