Cited by 4Platelet Disorders and TreatmentsCell Adhesion Molecules ResearchBlood Coagulation and Thrombosis Mechanisms

Pharmacological actions of morusinol on modulation of platelet functions via integrin αIIb/β3 signaling

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Kwon, Hyuk-Woo·2023·Journal of Applied Biological Chemistry

Abstract

Morus alba, a popular medicinal plant belonging to the family Moraceae, has long been used commonly in traditional medicine and has various physiological activities, including antidiabetic, anti-microbial, diuretic, anti-oxidant, and anti-cancer activities.Morusinol was isolated from the root bark of M. alba; however, its biological effects have not yet been reported.Therefore, we examined the inhibitory effects of morusinol on human platelet aggregation, Ca 2+ mobilization, and αIIb/β 3 activity.Our data showed that collagen-induced human platelet aggregation was inhibited by morusinol without cytotoxicity.In this study, we examined whether morusinol inhibits platelet aggregation through the regulation of integrin αIIb/β 3 and its associated signaling molecules.We observed that morusinol inhibited αIIb/β 3 activation by regulating vasodilator-stimulated phosphoprotein, phosphatidylinositol-3 kinase, Akt (protein kinase B), and glycogen synthase kinase-3α/β.These results show that morusinol inhibited fibronectin adhesion, fibrinogen binding, and clot retraction.Taken together, morusinol shows strong antiplatelet and anti-clot retraction effects and is a potential therapeutic drug candidate to prevent plateletrelated thrombosis and cardiovascular disease.

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  • Morusinol reportedly regulates beta3-integrin, tumor necrosis factor, and interleukin 1 beta involved in osteoclastogenesis.

    “morusinol reportedly regulates beta3-integrin, tumor necrosis factor, and interleukin 1 beta involved in osteoclastogenesis”

    From Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis (2025) · cites this paper as [35]

    The Discussion (page unavailable) reports that morusinol inhibits integrin αIIb/β3 activation in human platelets. The paper does not report regulation of tumor necrosis factor or interleukin 1 beta, or examine osteoclastogenesis; searches for those terms returned no relevant passage. (LLM, conf=0.86)

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Authors
Kwon, H.-W.
Affiliations
Far East University (KR)
Corresponding author
Kwon, Hyuk-Woo
Venue
Journal of Applied Biological Chemistry
Published
2023-04-25
Volume
66
ISSN
  • 1976-0442 (ISSN-L)
  • 2234-7941
OpenAlex
W4366990975
Cited by
4
References
25
Citations by year
2026: 2 · 2025: 2
FWCI
0.82
Type
journal article
Language
en
Open access
Locations
Journal of Applied Biological Chemistry (publishedVersion, cc-by-nc)
Funders
Far East University (FEU2022S04)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords
Morus alba, antiplatelet activity, platelet aggregation, integrin αIIbβ3, calcium mobilization, VASP, phosphatidylinositol 3-kinase, Akt, glycogen synthase kinase-3, clot retraction, fibrinogen binding, fibronectin adhesion, thromboprophylaxis, cardiovascular disease, root bark extract

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