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Study of the in vitro cytotoxicity testing of medical devices
Open accessAbstract
The cytotoxicity test is one of the biological evaluation and screening tests that use tissue cells in vitro to observe the cell growth, reproduction and morphological effects by medical devices. Cytotoxicity is preferred as a pilot project test and an important indicator for toxicity evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity. Three types of cytotoxicity test are stated in the International Organization for Standardization 109993‑5: Extract, direct contact and indirect contact tests. The xCELLigence real‑time cell analysis system shows a significant potential in regards to cytotoxicity in recent years. The present review provides a brief insight into the in vitro cytotoxicity testing of medical devices.
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Cites
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
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Gruber, S., & Nickel, A. (2023) · Frontiers in Medical Technology · doi:10.3389/fmedt.2023.1195529 · Cited by 200
Biodegradable magnesium alloys for orthopaedic applications
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Ghasemi Toudeshkchouei, M., Zahedi, P., & Shavandi, A. (2020) · Materials · doi:10.3390/ma13071483 · Cited by 39
Alsharbaty, M. H. M., Naji, G. A., Ghani, B. A., Schagerl, M., Khalil, M. A., & Ali, S. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-68020-7 · Cited by 8
Metadata
- Authors
- LI, W., ZHOU, J., & XU, Y.
- Venue
- Biomedical Reports
- Publisher
- Spandidos Publications
- Published
- 2015-06-19
- Volume
- 3
- Issue
- 5
- Pages
- 617-620
- ISSN
- 2049-9434 (ISSN-L)
- 2049-9442
- OpenAlex
- W1955049927
- Cited by
- 461
- References
- 1
- FWCI
- 27.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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