Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy
Open accessAbstract
The aim of this study was to explore the association between adiponectin (APN), APN receptors and insulin resistance (IR) using rats with type 2 diabetes mellitus (T2DM) as a model of diabetic cardiomyopathy (DC). Serum and cardiac APN levels were assessed using a double-antibody sandwich ELISA. In addition, the mRNA and protein expression of the myocardial APN receptor 1 (AdipoR1) was determined using the reverse transcription polymerase chain reaction and immunohistochemical staining. The results showed that the heart weight/body weight ratio, fasting plasma glucose (FPG) and lipid levels, and the homeostasis model assessment-estimated IR (HOMA-IR) index were elevated in the T2DM group compared with the control group. Cardiac function was significantly lower in the T2DM group compared with the control group (P<0.05). Furthermore, serum and cardiac APN levels were significantly reduced in the T2DM group compared with the control group, and mRNA and protein expression of AdipoR1 was lower in the T2DM group compared with the control group (P<0.05). Changes in the morphology of myocardial cells were observed under the light microscope using hematoxylin and eosin staining. Myocardial cell hypertrophy, a disordered cell arrangement and irregular nuclear size were observed in the T2DM group. By contrast, myocardial cells in the control group were arranged in neat rows with uniform cytoplasmic and nuclear staining. According to the correlation analyses, serum APN levels in the T2DM group were negatively correlated with FPG, triglyceride, total cholesterol and fasting insulin (FINS) levels, as well as with the HOMA-IR index. Myocardial AdipoR1 protein expression was positively correlated with myocardial APN levels, and negatively correlated with FINS and HOMA-IR. It may be concluded that myocardial and serum levels of APN are reduced in rats with DC. Metabolic disorders of blood glucose and lipid levels, as well as IR, are associated with low APN levels. Furthermore, low levels of myocardial Adipo1R mRNA and protein expression correlate with reduced insulin sensitivity.
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Low plasma levels of adiponectin seen in diabetes contribute to the oxidative damage seen in DCM.
“Adiponectin is a hormone secreted by adipose tissue that regulates metabolic processes and functions as an antioxidant; the low plasma levels of adiponectin seen in diabetes contribute to the oxidative damage seen in DCM [24, 25].”
From Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population (2016) · cites this paper as [24]
The Results (Expression of serum and myocardial APN and myocardial AdipoR1; page unavailable) report lower serum adiponectin in rats with type 2 diabetes used as a model of diabetic cardiomyopathy. The Discussion (page unavailable) says adiponectin and its receptor can improve oxidative stress, but the paper does not show that low adiponectin causes oxidative damage in diabetic cardiomyopathy. (LLM, conf=0.86)
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Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity
Stumvoll, M., Tschritter, O., Fritsche, A., Staiger, H., Renn, W., Weisser, M., Machicao, F., & Häring, H. (2002) · Diabetes · doi:10.2337/diabetes.51.1.37 · Cited by 371 · see citing works
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Kim, Y., Lim, J. H., Kim, M. Y., Kim, E. N., Yoon, H. E., Shin, S. J., Choi, B. S., Kim, Y.-S., Chang, Y. S., & Park, C. W. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017060627 · Cited by 229 · see citing works
Shaver, A., Nichols, A., Thompson, E., Mallick, A., Payne, K., Jones, C., Manne, N. D. P. K., Sundaram, S., Shapiro, J. I., & Sodhi, K. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.14141 · Cited by 54 · see citing works
“Adiponectin is a hormone secreted by adipose tissue that regulates metabolic processes and functions as an antioxidant; the low plasma levels of adiponectin seen in diabetes contribute to the oxidative damage seen in DCM [24, 25].”
- Authors
- LI, J., SU, S., & ZONG, X.
- Affiliations
- First Affiliated Hospital of Anhui Medical University (CN)
- Corresponding author
- LI, JIEHUA
- ORCID
- LI, JIEHUA
- Venue
- Experimental and Therapeutic Medicine
- Publisher
- Spandidos Publications
- Published
- 2014-02-12
- Volume
- 7
- Issue
- 4
- Pages
- 1023-1027
- ISSN
- 1792-0981 (ISSN-L)
- 1792-1015
- PMC
- PMC3964935
- OpenAlex
- W1999055087
- Cited by
- 22
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Experimental and Therapeutic Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- adiponectin, AdipoR1, diabetic cardiomyopathy, type 2 diabetes, insulin resistance, cardiac hypertrophy, cardiac function, HOMA-IR, fasting insulin, lipid metabolism
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