The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes
Open accessAbstract
Adiponectin exerts renoprotective effects against diabetic nephropathy (DN) by activating the AMP-activated protein kinase (AMPK)/peroxisome proliferative-activated receptor– α (PPAR α ) pathway through adiponectin receptors (AdipoRs). AdipoRon is an orally active synthetic adiponectin receptor agonist. We investigated the expression of AdipoRs and the associated intracellular pathways in 27 patients with type 2 diabetes and examined the effects of AdipoRon on DN development in male C57BLKS/J db/db mice, glomerular endothelial cells (GECs), and podocytes. The extent of glomerulosclerosis and tubulointerstitial fibrosis correlated with renal function deterioration in human kidneys. Expression of AdipoR1, AdipoR2, and Ca 2+ /calmodulin-dependent protein kinase kinase– β (CaMKK β ) and numbers of phosphorylated liver kinase B1 (LKB1)– and AMPK-positive cells significantly decreased in the glomeruli of early stage human DN. AdipoRon treatment restored diabetes-induced renal alterations in db/db mice. AdipoRon exerted renoprotective effects by directly activating intrarenal AdipoR1 and AdipoR2, which increased CaMKK β , phosphorylated Ser 431 LKB1, phosphorylated Thr 172 AMPK, and PPAR α expression independently of the systemic effects of adiponectin. AdipoRon-induced improvement in diabetes-induced oxidative stress and inhibition of apoptosis in the kidneys ameliorated relevant intracellular pathways associated with lipid accumulation and endothelial dysfunction. In high-glucose–treated human GECs and murine podocytes, AdipoRon increased intracellular Ca 2+ levels that activated a CaMKK β /phosphorylated Ser 431 LKB1/phosphorylated Thr 172 AMPK/PPAR α pathway and downstream signaling, thus decreasing high-glucose–induced oxidative stress and apoptosis and improving endothelial dysfunction. AdipoRon further produced cardioprotective effects through the same pathway demonstrated in the kidney. Our results show that AdipoRon ameliorates GEC and podocyte injury by activating the intracellular Ca 2+ /LKB1-AMPK/PPAR α pathway, suggesting its efficacy for treating type 2 diabetes–associated DN.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AdipoRon has been proposed for treatment of type 2 diabetes and other obesity-related disorders in mice.
“AdipoRon has first been proposed for the treatment of type 2 diabetes and other obesity-related disorders in mice [32,106,107,108,137,138].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [32]
Cites
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works
Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396 · see citing works
Woods, A., Dickerson, K., Heath, R. B., Hong, S. P., Momcilovic, M., Johnstone, S. R., Carlson, M., & Carling, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.005 · Cited by 1,395 · see citing works
Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1
Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works
Mundel, P. H., Reiser, J., Zúñiga, A., Pavenstädt, H., Davidson, G. R., Kriz, W., & Zeller, R. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3739 · Cited by 876 · see citing works
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 667 · see citing works
Adiponectin regulates albuminuria and podocyte function in mice
Sharma, K., RamachandraRao, S., Qiu, G., Usui, H. K., Zhu, Y., Dunn, S., Ouedraogo, R., Hough, K., McCue, P. A., Chan, L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32691 · Cited by 607 · see citing works
Lipid Metabolism and Toxicity in the Heart
Goldberg, I. J., Trent, C. M., & Schulze, P. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.006 · Cited by 586 · see citing works
Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402367200 · Cited by 550 · see citing works
Suter, M., Riek, U., Tuerk, R. D., Schlattner, U., Wallimann, T., & Neumann, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606357200 · Cited by 479 · see citing works
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 467 · see citing works
Jiang, T., Wang, Z., Proctor, G., Moskowitz, S., Liebman, S. E., Rogers, T. E., Lucia, M. S., Li, J., & Levi, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500801200 · Cited by 387 · see citing works
Kim, M. Y., Lim, J. H., Youn, H. H., Hong, Y. A., Yang, K. S., Park, H., Chung, S., Koh, S. H., Shin, S. J., Choi, B. S., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2747-2 · Cited by 313 · see citing works
Ouedraogo, R., Wu, X., Xu, S., Fuchsel, L., Motoshima, H., Mahadev, K., Hough, K., Scalia, R. G., & Goldstein, B. J. (2006) · Diabetes · doi:10.2337/db05-1174 · Cited by 250 · see citing works
DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity
Liu, L., Shi, X., Bharadwaj, K. G., Ikeda, S., Yamashita, H., Yagyu, H., Schaffer, J. E., Yu, Y., & Goldberg, I. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.049817 · Cited by 240 · see citing works
Screening, Monitoring, and Treatment of Albuminuria
de Jong, P. E., & Curhan, G. C. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010097 · Cited by 213 · see citing works
Zhou, L., Deepa, S. S., Etzler, J. C., Ryu, J., Mao, X., Fang, Q., Liu, D. D., Torres, J. M., Jia, W., Lechleiter, J. D., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028357 · Cited by 212 · see citing works
Rakatzi, I., Mueller, H., Ritzeler, O., Tennagels, N., & Eckel, J. (2004) · Diabetologia · doi:10.1007/s00125-003-1293-3 · Cited by 180 · see citing works
Delaney, B., Frazer, S. R., Hess, R., Ostergren, K., Haworth, J., Knutson, N., Nicolosi, R. J., Wilson, T. A., Carlson, T. L., & Zheng, G.-H. (2003) · Journal of Nutrition · doi:10.1093/jn/133.2.468 · Cited by 172 · see citing works
Siddiqi, F. S., & Advani, A. (2013) · Diabetes · doi:10.2337/db13-0795 · Cited by 133 · see citing works
Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
Hong, Y. A., Lim, J. H., Kim, M. Y., Kim, T. W., Kim, Y., Yang, K. S., Park, H. S., Choi, S. R., Chung, S., Kim, H. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096147 · Cited by 118 · see citing works
Handa, P., Maliken, B. D., Nelson, J. E., Morgan‐Stevenson, V., Messner, D. J., Dhillon, B. K., Klintworth, H. M., Beauchamp, M. D., Yeh, M. M., Elfers, C., et al. (2013) · Hepatology · doi:10.1002/hep.26946 · Cited by 95 · see citing works
Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification
Wang, Y., Ma, X. L., & Lau, W. B. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.004 · Cited by 88 · see citing works
The role of adiponectin in renal physiology and development of albuminuria
Christou, G. A., & Kiortsis, D. N. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0578 · Cited by 86 · see citing works
Ronning After the Adiponectin Receptors
Holland, W. L., & Scherer, P. E. (2013) · Science · doi:10.1126/science.1249077 · Cited by 79 · see citing works
Cha, D. R., Zhang, X., Zhang, Y., Wu, J., Su, D., Han, J., Fang, X., Yu, B., Breyer, M. D., & Guan, Y. (2007) · Diabetes · doi:10.2337/db06-1134 · Cited by 76 · see citing works
Cammisotto, P., Londoño, I., Gingras, D., & Bendayan, M. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00373.2007 · Cited by 72 · see citing works
Shin, S. J., Lim, J. H., Chung, S., Youn, D., Chung, H. W., Kim, H. W., Lee, J. H., Chang, Y. S., & Park, C. W. (2009) · Hypertension Research · doi:10.1038/hr.2009.107 · Cited by 63 · see citing works
Role of PPARγ in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential
Yang, J., Zhang, D., Li, J., Zhang, X., Fan, F., & Guan, Y. (2008) · Clinical Science · doi:10.1042/cs20070462 · Cited by 61 · see citing works
Tamba, S., Nakatsuji, H., Kishida, K., Noguchi, M., Ogawa, T., Okauchi, Y., Nishizawa, H., Imagawa, A., Nakamura, T., Matsuzawa, Y., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.02.037 · Cited by 49 · see citing works
Adiponectin is expressed and secreted by renal tubular epithelial cells
Perri, A., Vizza, D., Lofaro, D., Gigliotti, P., Leone, F., Brunelli, E., Malivindi, R., Amicis, F. D., Romeo, F., Stefano, R. D., et al. (2013) · Journal of Nephrology · doi:10.5301/jn.5000269 · Cited by 40 · see citing works
Plasma adiponectin is related to the progression of kidney disease in type 2 diabetes patients
Kacsó, I. M., Bondor, C. I., & Kacsó, G. (2012) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2012.668928 · Cited by 34 · see citing works
Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1
Koentges, C., König, A., Pfeil, K., Hölscher, M. E., Schnick, T., Wende, A. R., Schrepper, A., Cimolai, M. C., Kersting, S., Hoffmann, M. M., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0495-4 · Cited by 32 · see citing works
Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy
LI, J., SU, S., & ZONG, X. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1539 · Cited by 22 · see citing works
Changes of adiponectin and its receptors in rats following chronic renal failure
Yu, Y., Bao, B., Fan, Y., Shi, L., & Li, S.-Q. (2013) · Renal Failure · doi:10.3109/0886022x.2013.830975 · Cited by 22 · see citing works
Damned If You Do, Damned If You Don’t: The Conundrum of Adipose Tissue Vascularization
Yilmaz, M., & Hotamışlıgil, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.014 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072632 · Cited by 363 · see citing works
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism
Fu, Y., Sun, Y., Wang, M., Hou, Y., Huang, W. C., Zhou, D., Wang, Z., Yang, S., Tang, W., Zhen, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.019 · Cited by 217 · see citing works
Tuleta, I., & Frangogiannis, N. G. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166044 · Cited by 216 · see citing works
Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction
Nishi, H., Higashihara, T., & Inagi, R. (2019) · Nutrients · doi:10.3390/nu11071664 · Cited by 174 · see citing works
PPARα: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases
Lin, Y., Wang, Y., & Li, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1074911 · Cited by 146 · see citing works
Renal Lipid Metabolism and Lipotoxicity in Diabetes
Thongnak, L., Pongchaidecha, A., & Lungkaphin, A. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.11.004 · Cited by 132 · see citing works
Han, Y., Xiong, S., Zhao, H., Yang, S., Yang, M., Zhu, X., Jiang, N., Xiong, X., Gao, P., Wei, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04326-y · Cited by 120 · see citing works
Kim, Y., & Park, C. W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071782 · Cited by 110 · see citing works
Sugahara, M., Tanaka, S., Tanaka, T., Saito, H., Ishimoto, Y., Wakashima, T., Ueda, M., Fukui, K., Shimizu, A., Inagi, R., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019060582 · Cited by 108 · see citing works
Obesity-related kidney disease: Beyond hypertension and insulin-resistance
Arabi, T. Z., Shafqat, A., Sabbah, B. N., Ashraf, N., Shah, H., Abdulkader, H. S., Razak, A., Sabbah, A. N., & Arabi, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1095211 · Cited by 98 · see citing works
The Contribution of Lipotoxicity to Diabetic Kidney Disease
Schelling, J. R. (2022) · Cells · doi:10.3390/cells11203236 · Cited by 86 · see citing works
Ge, X., Wang, J.-L., Liu, X., Zhang, J., Liu, C., & Guo, L. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0160-2 · Cited by 83 · see citing works
Li, Z., Guo, H., Li, J. X., Ma, T., Zhou, S., Zhang, Z., Miao, L., & Cai, L. (2020) · Clinical Science · doi:10.1042/cs20191088 · Cited by 80 · see citing works
Adipocytokines: Are they the Theory of Everything?
Maximus, P., Achkar, Z. A., Hamid, P., Hasnain, S. S., & Peralta, C. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155144 · Cited by 77 · see citing works
Piani, F., Melena, I. L., Tommerdahl, K. L., Nokoff, N., Nelson, R. G., Pavkov, M. E., van Raalte, D. H., Cherney, D. Z. I., Johnson, R. J., Nadeau, K. J., et al. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107841 · Cited by 76 · see citing works
Interplay of lipid metabolism and inflammation in podocyte injury
Luo, Z., Chen, Z., Hu, J., & Ding, G. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155718 · Cited by 74 · see citing works
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
Liu, Y., Vu, V., & Sweeney, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00842 · Cited by 69 · see citing works
An updated pharmacological insight of resveratrol in the treatment of diabetic nephropathy
Li, K., Ji, M., & Sun, H. (2021) · Gene · doi:10.1016/j.gene.2021.145532 · Cited by 69 · see citing works
Lipid homeostasis in diabetic kidney disease
Wang, Y., Liu, T.-T., Wu, Y., Wang, L., Ding, S.-W., Hou, B., Zhao, H.-L., Liu, W.-J., & Li, P. (2024) · International Journal on Biological Sciences · doi:10.7150/ijbs.95216 · Cited by 72 · see citing works
Yang, S., Ma, C.-R., Wu, H., Zhang, H., Yuan, F., Yang, G., Yang, Q., Jia, L., Liang, Z., & Kang, L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104678 · Cited by 68 · see citing works
Lipid metabolism disorder in diabetic kidney disease
Han, Y.-Z., Du, B., Zhu, X., Wang, Y.-Z.-Y., Zheng, H., & Liu, W. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1336402 · Cited by 73 · see citing works
Chae, S. Y., Kim, Y., & Park, C. W. (2023) · Antioxidants · doi:10.3390/antiox12122083 · Cited by 63 · see citing works
Rahhal, M.-N., Gharaibeh, N. E., Rahimi, L., & Ismail‐Beigi, F. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00286 · Cited by 60 · see citing works
Obesity-Related Glomerulopathy: A Latent Change in Obesity Requiring More Attention
Yang, S., Cao, C., Deng, T., & Zhou, Z. (2020) · Kidney & Blood Pressure Research · doi:10.1159/000507784 · Cited by 60 · see citing works
Role of Perivascular Adipose Tissue-Derived Adiponectin in Vascular Homeostasis
Sówka, A., & Dobrzyń, P. (2021) · Cells · doi:10.3390/cells10061485 · Cited by 62 · see citing works
Khandelwal, M., Manglani, K., Upadhyay, P., Azad, M., & Gupta, S. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105876 · Cited by 55 · see citing works
Lindfors, S., Polianskyte-Prause, Z., Bouslama, R., Lehtonen, E., Mannerla, M., Nísen, H., Tienari, J., Salmenkari, H., Forsgård, R. A., Mirtti, T. K., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05473-9 · Cited by 54 · see citing works
The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
Sun, Y., Cui, S., Hou, Y., & Yi, F. (2021) · Kidney Diseases · doi:10.1159/000518132 · Cited by 54 · see citing works
Yang, M., Abdullah, Ahmad, N., Hussain, M. H., Lu, X., Xu, J., Zhong, H., & Guan, R. (2023) · Food & Function · doi:10.1039/d2fo03824b · Cited by 54 · see citing works
Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease
Ning, B., Guo, C., Kong, A., Li, K., Xie, Y., Shi, H., & Gu, J. (2021) · Cells · doi:10.3390/cells10113204 · Cited by 52 · see citing works
Adipokines as Clinically Relevant Therapeutic Targets in Obesity
Würfel, M., Blüher, M., Stümvoll, M., Ebert, T., Kovacs, P. L., Tönjes, A., & Breitfeld, J. (2023) · Biomedicines · doi:10.3390/biomedicines11051427 · Cited by 54 · see citing works
The role of adiponectin in cardiovascular disease
Peng, J., Chen, Q., & Wu, C. (2023) · Cardiovascular Pathology · doi:10.1016/j.carpath.2022.107514 · Cited by 50 · see citing works
Li, H., Ouyang, Y., Lv, H., Liang, H., Luo, S., Zhang, Y., Mao, H., Chen, T., Chen, W., Zhou, Y., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122926 · Cited by 50 · see citing works
Zhuo, Y., Hua, L., Feng, B., Jiang, X., Li, J., Jiang, D., Huang, X., Yingguo, Z., Li, Z., Yan, L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.020 · Cited by 49 · see citing works
Zhou, H., Ni, W., Meng, X., & Tang, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.618536 · Cited by 49 · see citing works
AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments
Nigro, E., Daniele, A., Salzillo, A., Ragone, A., Naviglio, S., & Sapio, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115569 · Cited by 46 · see citing works
An Adiponectin Receptor Agonist Reduces Type 2 Diabetic Periodontitis
Wu, X., Qiu, W., Hu, Z., Lian, J., Liu, Y., Zhu, X., Tu, M., Fang, F., Yu, Y., Valverde, P., et al. (2019) · Journal of Dental Research · doi:10.1177/0022034518818449 · Cited by 45 · see citing works
Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy
Hou, B., He, P., Ma, P., Yang, X., Xu, C., Lam, S. M., Shui, G., Yang, X., Zhang, L., Qiang, G., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00359 · Cited by 45 · see citing works
<scp>AdipoRon</scp>, a new therapeutic prospect for Duchenne muscular dystrophy
Abou‐Samra, M., Selvais, C. M., Boursereau, R., Lecompte, S., Noel, L., & Brichard, S. M. (2020) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12531 · Cited by 44 · see citing works
Liu, P., Peng, L., Zhang, H., Tang, P. M., Zhao, T., Yan, M., Zhao, H., Huang, X., Lan, H., & Li, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00343 · Cited by 44 · see citing works
Bhat, I. A., Kabeer, S. W., Reza, M. I., Mir, R. H., & Dar, M. O. (2019) · Current Molecular Pharmacology · doi:10.2174/1874467212666191022102800 · Cited by 39 · see citing works
AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells
Sapio, L., Nigro, E., Ragone, A., Salzillo, A., Illiano, M., Spina, A., Polito, R., Daniele, A., & Naviglio, S. (2020) · Journal of Oncology · doi:10.1155/2020/7262479 · Cited by 40 · see citing works
Sutthasupha, P., Promsan, S., Thongnak, L., Pengrattanachot, N., Phengpol, N., Jaruan, O., Jaikumkao, K., Muanprasat, C., Pichyangkura, R., Chatsudthipong, V., et al. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119405 · Cited by 39 · see citing works
Maalouf, N. M., POINDEXTER, J. R., ADAMS-HUET, B. A., Moe, O. W., & Sakhaee, K. (2019) · Kidney International · doi:10.1016/j.kint.2018.11.024 · Cited by 39 · see citing works
Jing, H., Tang, S., Lin, S., Liao, M., Chen, H., Fan, Y., & Zhou, J. (2020) · Aging · doi:10.18632/aging.102811 · Cited by 39 · see citing works
A minireview: Role of AMP-activated protein kinase (AMPK) signaling in obesity-related renal injury
Zhuo, L., Li, J. X., Miao, X., Cui, W., Miao, L., & Cai, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118828 · Cited by 40 · see citing works
Feng, X., Gao, X., Wang, S., Huang, M., Sun, Z., Dong, H., Yu, H., & Wang, G. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.652558 · Cited by 39 · see citing works
Zhang, Z., Ni, L., Zhang, L., Zha, D., Hu, C., Zhang, L., Feng, H. A., Wei, X., & Wu, X. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s289712 · Cited by 38 · see citing works
Tan, W., Wang, Y., Cheng, S., Liu, Z., Xie, M., Song, L., Qiu, Q., Wang, X., Li, Z., Liu, T., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.02.015 · Cited by 37 · see citing works
The dual role of lipids in chronic kidney disease: Pathogenic culprits and therapeutic allies
Giardini, E., Moore, D., Sadlier, D. M., Godson, C., & Brennan, E. P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118615 · Cited by 36 · see citing works
Adiponectin for the treatment of diabetic nephropathy
Lee, J. Y., Yang, J. W., Han, B. G., Choi, S. O., & Kim, J. S. (2019) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2019.109 · Cited by 37 · see citing works
Zhao, J., He, K., Du, H., Wei, G., Wen, Y., Wang, J., Zhou, X., & Wang, J. (2022) · PeerJ · doi:10.7717/peerj.13932 · Cited by 34 · see citing works
Juszczak, F., Pierre, L., Decarnoncle, M., Jadot, I., Martin, B., Botton, O., Caron, N., Dehairs, J., Swinnen, J. V., & Declèves, A. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00543-6 · Cited by 35 · see citing works
High Fat Diet Induces Kidney Injury via Stimulating Wnt/β-Catenin Signaling
Yu, Y., Mo, H., Zhuo, H., Chen, Y., & Liu, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.851618 · Cited by 33 · see citing works
Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases
Huang, W., Chen, Y., Li, Z., He, F., & Zhang, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810882 · Cited by 32 · see citing works
Zhai, R., Jian, G., Chen, T., Xie, L., Xue, R., Gao, C., Wang, N., Xu, Y., & Gui, D. (2019) · Journal of Diabetes Research · doi:10.1155/2019/1602892 · Cited by 32 · see citing works
Early diabetic kidney disease: Focus on the glycocalyx
Yu, H., Song, Y.-Y., & Li, X. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i5.460 · Cited by 32 · see citing works
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells
Sung, H. K., Mitchell, P. L., Gross, S. M., Marette, A., & Sweeney, G. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00603.2020 · Cited by 30 · see citing works
Clain, J., Couret, D., Planesse, C., Trotot, P. K., Meilhac, O., d’Hellencourt, C. L., Viranaïcken, W., & Diotel, N. (2022) · Brain Sciences · doi:10.3390/brainsci12050680 · Cited by 31 · see citing works
Gao, X., Sun, H., Wei, Y.-D., Niu, J., Hao, S., Sun, H., Tang, G., Qi, C., & Ge, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155805 · Cited by 30 · see citing works
Li, Q., Liu, J., Su, R., Zhen, J., Liu, X., & Liu, G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112667 · Cited by 30 · see citing works
Kounatidis, D. C., Vallianou, N. G., Karampela, Ι., Grivakou, E., & Dalamaga, Μ. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.013 · Cited by 30 · see citing works
Xu, Y., Zhu, H., Li, W., Chen, D., Xu, Y., Xu, A., & Ye, D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108284 · Cited by 30 · see citing works
Wang, S., Li, D., Huang, C., Wan, Y., Wang, J., Zan, X., & Yang, B. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.050 · Cited by 29 · see citing works
Drapkina, O. M., Elkina, A. Y., Sheptulina, A. F., & Kiselev, A. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098445 · Cited by 29 · see citing works
Zhang, Y., Zhang, Y.-L., Huang, Q., Huang, C., Jiang, Z., Cai, F., & Shen, J. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s221841 · Cited by 28 · see citing works
Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms
Wu, H., Zhang, Y., Li, Y., Xu, J., Wang, Y., & Li, X. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c02382 · Cited by 28 · see citing works
Pal, S., Singh, M., Porwal, K., Rajak, S., Das, N., Rajput, S., Trivedi, A. K., Maurya, R., Sinha, R. A., Siddiqi, M. I., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174634 · Cited by 28 · see citing works
Mallik, R., & Chowdhury, T. A. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221081601 · Cited by 28 · see citing works
Fawaz, S., Alonso, A. M., Qiu, Y., Ramnath, R. D., Stowell-Connolly, H., Gamez, M., May, C., Down, C. J., Coward, R. J., Butler, M. J., et al. (2024) · Diabetes · doi:10.2337/db23-0455 · Cited by 29 · see citing works
Onodera, T., Zadeh, E. H. G., Xu, P. H., Gordillo, R., Guo, Z., Joffin, N., Yu, B., Scherer, P. E., & Li, W. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100095 · Cited by 26 · see citing works
Ceramides and Acute Kidney Injury
Nicholson, R. J., Holland, W. L., & Summers, S. A. (2022) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2022.10.007 · Cited by 25 · see citing works
Mechanism of progression of diabetic kidney disease mediated by podocyte mitochondrial injury
Su, J., Ye, D., Gao, C., Huang, Q., & Gui, D. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05749-0 · Cited by 25 · see citing works
Qiu, X., Lan, X., Li, L., Chen, H., ZHANG, N., Zheng, X., & Xie, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122866 · Cited by 24 · see citing works
Wang, B., Li, J., Bao, M., Chen, R., Li, H., Lu, B., Chen, M., Huang, D., Zhang, Y., Gao, F., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8882130 · Cited by 23 · see citing works
Neves, K. B., Montezano, A. C., Alves-Lopes, R., Bruder-Nascimento, T. B., da Costa, R. M., Costa, R. S., Touyz, R. M., & Tostes, R. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082454 · Cited by 23 · see citing works
Xue, H.-Z., Chen, Y., Wang, S.-D., Yang, Y.-M., Cai, L.-Q., Zhao, J., Huang, W., & Xiao, Y. (2024) · Journal of Diabetes Research · doi:10.1155/2024/5216113 · Cited by 22 · see citing works
Wu, X., Sun, Y., Cui, R., Qiu, W., Zhang, J., Hu, Z., Bi, W., Yang, F., Ma, D., Dyke, T. E. V., et al. (2022) · Journal of Periodontal Research · doi:10.1111/jre.12969 · Cited by 22 · see citing works
Gu, D., Shi, Y., Gong, Z., Xia, T., Ren, H., He, D., Yang, J., Han, Y., & Zeng, C. (2020) · Clinical and Experimental Nephrology · doi:10.1007/s10157-020-01944-2 · Cited by 21 · see citing works
Wang, Y., Liu, T., Ma, F., Lu, X., Mao, H., Zhou, W., Yang, L., Li, P., & Zhan, Y. (2020) · Journal of Diabetes Research · doi:10.1155/2020/2421631 · Cited by 21 · see citing works
Wang, C., Xu, M., Feng, R., Zhang, L., Yin, X., Feng, R., Liang, K., & Liu, J. (2022) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-002972 · Cited by 20 · see citing works
Das, S., Rajeswari, V. D., Venkatraman, G., Elumalai, R., Sivaraman, D., & Ramanathan, G. (2023) · Translational research · doi:10.1016/j.trsl.2023.11.002 · Cited by 20 · see citing works
Advances in understanding the role of adiponectin in renal fibrosis
Zhao, D., Zhu, X., Jiang, L., Huang, X., Zhang, Y., Wei, X. S., Zhao, X., & Du, Y. (2020) · Nephrology · doi:10.1111/nep.13808 · Cited by 19 · see citing works
Anti-Obesity Effect of Erigeron annuus (L.) Pers. Extract Containing Phenolic Acids
Zheng, Y., Choi, Y., Lee, J., Lee, S.-Y., & Kang, I. (2021) · Foods · doi:10.3390/foods10061266 · Cited by 19 · see citing works
Wang, W., Bale, S., Wei, J., Yalavarthi, B., Bhattacharyya, D., Yan, J. J., Abdala‐Valencia, H., Xu, D., Sun, H., Marangoni, R. G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33767-y · Cited by 19 · see citing works
Zhao, Y., Sun, N., Song, X., Zhu, J., Wang, T., Wang, Z., Yu, Y., Ren, J. L., Chen, H., Zhan, T., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.04.001 · Cited by 18 · see citing works
Chen, Y., Tao, J., He, Y., Hou, X.-D., Ji, F., Huang, J., Wang, L., Shen, J., Zhu, B., Wang, N., et al. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01521-1 · Cited by 19 · see citing works
Wang, Y., He, Z., Yang, Q., & Zhou, G. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12655 · Cited by 19 · see citing works
RetractedHu, H., Li, W., Liu, M., Xiong, J., Li, Y., Wei, Y., Huang, C., & Tang, Y. (2020) · DNA and Cell Biology · doi:10.1089/dna.2019.5302 · Cited by 19 · see citing works
Insights Into the Controversial Aspects of Adiponectin in Cardiometabolic Disorders
Francischetti, E. A., Dezonne, R. S., Pereira, C. M., Martins, C. J. D. M., Celoria, B. M. J., de Oliveira, P. A. C., & de Abreu, V. G. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1239-4349 · Cited by 19 · see citing works
Gamberi, T., Magherini, F., & Fiaschi, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071544 · Cited by 18 · see citing works
Liu, Y., Ma, X., Le, Y., Feng, J., Xu, M., Wang, W., & Wang, C. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14634 · Cited by 18 · see citing works
Laurindo, L. F., Sosin, A. F., Lamas, C. B., Goulart, R. D. Á., Haber, J. F. D. S., Detregiachi, C. R. P., & Barbalho, S. M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02792-z · Cited by 18 · see citing works
Kaewin, S., Poolsri, W., Korkut, G. G., Patrakka, J., Aiebchun, T., Rungrotmongkol, T., Sungkaworn, T., Sukanadi, I. P., Chavasiri, W., & Muanprasat, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115158 · Cited by 17 · see citing works
Zuo, F., Liu, Z.-Y., Wang, M., Du, J., Ding, P.-Z., Zhang, H., Tang, W., Sun, Y., Wang, X., Zhang, Y., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01213-4 · Cited by 17 · see citing works
Chen, Y., Zhang, M., Jia, R., Qian, B., Jing, C., Caihong, Z., Zhu, D., Liu, Z., Zen, K., & Li, L. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103439 · Cited by 17 · see citing works
Zhang, H., Sun, Y., Zou, Y., Chen, C., & Wang, S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117193 · Cited by 16 · see citing works
Choi, S.-K., Kwon, Y., Byeon, S., Haam, C. E., & Lee, Y.-H. (2020) · PLOS ONE · doi:10.1371/journal.pone.0230227 · Cited by 15 · see citing works
Zhang, J., Li, Y., Liu, J., Han, F., Shi, J., Wu, G., Wang, K., Shen, K., Zhao, M., Gao, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105236 · Cited by 15 · see citing works
- Authors
- Kim, Y., Lim, J. H., Kim, M. Y., Kim, E. N., Yoon, H. E., Shin, S. J., Choi, B. S., Kim, Y.-S., Chang, Y. S., & Park, C. W.
- Affiliations
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- Corresponding author
- Park, Cheol Whee
- Venue
- Journal of the American Society of Nephrology
- Published
- 2018-01-12
- Volume
- 29
- Issue
- 4
- Pages
- 1108-1127
- ISSN
- 1046-6673 (ISSN-L)
- 1533-3450
- PMC
- PMC5875945
- OpenAlex
- W2783996679
- Cited by
- 229
- References
- 40
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 41 · 2023: 28 · 2022: 30 · 2021: 23 · 2020: 28 · 2019: 22 · 2018: 7
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yonsei University
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- AdipoRon, adiponectin receptor agonist, diabetic nephropathy, type 2 diabetes, AMPK, PPARα, CaMKKβ, LKB1, AdipoR1, AdipoR2, glomerular endothelial cells, podocytes, oxidative stress, apoptosis, endothelial dysfunction, intracellular calcium, cardioprotection, db/db mice
- MeSH terms
- Animals, Cells, Cultured, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Glucose, Humans, Male, Mice, Inbred C57BL, Mice, Obese, Phosphorylation, Piperidines, Protein Processing, Post-Translational, Apoptosis, Protein Serine-Threonine Kinases, Oxidative Stress, Endothelial Cells, PPAR alpha, Podocytes, Mice, Adiponectin, Receptors, Leptin, Receptors, Adiponectin, Calcium-Calmodulin-Dependent Protein Kinase Kinase, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review