Cell therapy for cerebral hemorrhage: Five year follow-up report
Open accessAbstract
The aim of the study was to examine treatment of cerebral hemorrhages with bone-marrow or human umbilical cord-derived mesenchymal stem cells (BMSCs or Hu-MSCs) and conventional surgical approaches, and determine and compare the effectiveness, feasibility, safety and reproducibility of each method. A retrospective analysis was performed on a cohort of cell-treated cerebral hemorrhage patients from October 1, 2007 to October 1, 2009. A total of 24 patients, all of whom received conventional surgical treatment, were classified as follows: i) The control group consisted of 8 patients who received only hematoma removal surgery, ii) the autologous group consisted of 7 patients who received additional autologous bone marrow mononuclear cell transplantation, and iii) the allograft group consisted of 9 patients who received additional umbilical cord mononuclear cell transplantation. After conventional hematoma removal surgery and X-ray supervision within 24 h and at 7 days, neurological disability and function tests were completed 3, 6, 12, 36 and 60 months later. The T-cell marker plasma levels were analyzed after 60 months. The results showed that, at approximately 3.5 months after graft the hematomas in all the groups were completely reabsorbed as observed on computed tomography scans. However, the functional outcomes in the cell-transplanted groups were better than in the control group after 5 years. While the National Institutes of Health Stroke Scale, modified Rankin score and modified Barthel index scores were simliar in the cell-transplanted groups, patients in the allograft group had better outcomes than those in the autologous graft group starting at 3 months and until the end of the follow-up period. The serum levels of T-cell markers CD4, CD56 and human leukocyte antigen-DR in the allograft group showed no signs of immunogenic graft complications and there were no significant differences in T-cell subtypes among the patient groups. The results of the present study suggest that, treatment of cerebral hemorrhage patients can be safely and effectively accomplished using Hu-MSC grafting and larger clinical trials should be considered in the future.
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Intracerebral injections are clinically feasible and are performed in a variety of clinical scenarios and preclinical settings.
“Intracerebral injections are clinically feasible, and are performed in a variety of clinical scenarios (17–23), as well as in various preclinical settings (4, 24–27).”
From Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection (2023) · cites this paper as [21]
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works
Qureshi, A. I., Mendelow, A. D., & Hanley, D. F. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60371-8 · Cited by 1,526 · see citing works
HLA‐G and immune tolerance in pregnancy
Hunt, J. S., Petroff, M. G., McIntire, R. H., & Ober, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2078rev · Cited by 523 · see citing works
Borlongan, C. V., Glover, L. E., Tajiri, N., Kaneko, Y., & Freeman, T. B. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.005 · Cited by 210 · see citing works
Lee, J. M., Jung, J., Lee, H.-J., Jeong, S. J., Cho, K. J., Hwang, S. G., & Kim, G. J. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.03.024 · Cited by 183 · see citing works
Cell based therapies for ischemic stroke: From basic science to bedside
Liu, X., Ye, R., Yan, T., Yu, S. P., Wei, L., Xu, G., Fan, X., Jiang, Y., Stetler, R. A., Liu, C., et al. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.007 · Cited by 179 · see citing works
Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies
D’souza, N., Rossignoli, F., Golinelli, G., Grisendi, G., Spano, C., Candini, O., Osturu, S., Catani, F., Paolucci, P., Horwitz, E. M., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0426-0 · Cited by 137 · see citing works
Saino, O., Taguchi, A., Nakagomi, T., Nakano‐Doi, A., Kashiwamura, S., Doe, N., Nakagomi, N., Soma, T., Yoshikawa, H., Stern, D. M., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22410 · Cited by 93 · see citing works
More insight into mesenchymal stem cells and their effects inside the body
Zou, Z., Zhang, Y., Hao, L., Wang, F., Liu, D., Su, Y., & Sun, H. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903456011 · Cited by 84 · see citing works
Recent advances on the non-classical major histocompatibility complex class I HLA-G molecule
Menier, C., Rouas‐Freiss, N., Favier, B., LeMaoult, J., Moreau, P., & Carosella, E. D. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01438.x · Cited by 74 · see citing works
Kim, S. J., Moon, G. J., Chang, W. H., Kim, Y., Bang, O. Y., & collaborators, F. T. S.-2. (. C. A. R. A. T. I. N.-2. (2013) · Trials · doi:10.1186/1745-6215-14-317 · Cited by 73 · see citing works
Fazekasova, H., Lechler, R. I., Langford, K. J., & Lombardi, G. (2010) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.362 · Cited by 59 · see citing works
Stem Cell Transplantation for Neuroprotection in Stroke
Shinozuka, K., Dailey, T., Tajiri, N., Ishikawa, H., Kaneko, Y., & Borlongan, C. V. (2013) · Brain Sciences · doi:10.3390/brainsci3010239 · Cited by 41 · see citing works
An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
Dailey, T., Metcalf, C., Mosley, Y. I., Sullivan, R., Shinozuka, K., Tajiri, N., Pabon, M. M., Acosta, S., Kaneko, Y., van Loveren, H., et al. (2013) · Journal of Clinical Medicine · doi:10.3390/jcm2040220 · Cited by 31 · see citing works
Qu, Z., Guo, S., Fang, G., Cui, Z., & Liu, Y. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0378-6 · Cited by 21 · see citing works
Self-citationCell therapy for bone nonunion: a retrospective study.
Qu, Z., Fang, G., Cui, Z., & Liu, Y. (2015) · PubMed · Cited by 20 · see citing works
Self-citationQu, Z., Guo, L., Fang, G., Cui, Z., Guo, S., & Liu, Y. (2012) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-012-9354-1 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Umbilical cord mesenchymal stromal cell transplantations: A systemic analysis of clinical trials
Can, A., Celikkan, F. T., & Çınar, Ö. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.08.004 · Cited by 139 · see citing works
Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells
Yang, G., Fan, X., Liu, Y., Jie, P., Mazhar, M., Liu, Y., Dechsupa, N., & Wang, L. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10539-9 · Cited by 107 · see citing works
Self-citationStem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage
Gao, L., Xu, W., Li, T., Chen, J., Shao, A., Yan, F., & Chen, G. (2018) · Cell Transplantation · doi:10.1177/0963689718773363 · Cited by 94 · see citing works
Stroke treatment: Is exosome therapy superior to stem cell therapy?
Cai, Y., Liu, W., Lian, L., Xu, Y., Bai, X., Xu, S., & Zhang, J. (2020) · Biochimie · doi:10.1016/j.biochi.2020.09.025 · Cited by 71 · see citing works
Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection
Tuma, J., Chen, Y.-J., Collins, M. G., Paul, A., Li, J., Han, H., Sharma, R., Murthy, N., & Lee, H. Y. (2023) · Biochemistry · doi:10.1021/acs.biochem.3c00371 · Cited by 65 · see citing works
Mesenchymal stem cells for hemorrhagic stroke: status of preclinical and clinical research
Turnbull, M. T., Zubair, A. C., Meschia, J. F., & Freeman, W. D. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0073-8 · Cited by 50 · see citing works
Neuroprotective Therapies for Spontaneous Intracerebral Hemorrhage
Kearns, K. N., Ironside, N. T., Park, M. S., Worrall, B. B., Southerland, A. M., Chen, C., & Ding, D. (2021) · Neurocritical Care · doi:10.1007/s12028-021-01311-3 · Cited by 46 · see citing works
Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier
Zhang, R., Xue, M., & Yong, V. W. (2021) · Cells · doi:10.3390/cells10102513 · Cited by 35 · see citing works
Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
Zhou, J., Xiong, Y., Kang, X., Pan, Z., Zhu, Q., Goldbrunner, R., Stavrinou, L. C., Lin, S., Hu, W., Zheng, F., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02965-2 · Cited by 34 · see citing works
Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges
Gong, Y., Hao, S., & Wang, B. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.653367 · Cited by 30 · see citing works
Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage
Yang, G., Fan, X., Mazhar, M., Yang, S., Xu, H., Dechsupa, N., & Wang, L. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.898497 · Cited by 29 · see citing works
Liêm, N. T., Vũ, D. C., Phuong, D. T. M., Doan, N. V., Forsyth, N. R., Heke, M., Thi, P. A. N., & Nguyen, X. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00564 · Cited by 21 · see citing works
Intracerebral Hemorrhage: Advances, Knowledge Gaps, and Future Directions
Liu, T., Jiang, W., Zhang, M., Xiong, S., Chen, L., Chen, X., & Jiang, R. (2025) · MedComm · doi:10.1002/mco2.70436 · Cited by 23 · see citing works
Potential of stem cell therapy in intracerebral hemorrhage
Huang, A. P., Hsu, Y.-H., Wu, M.-S., Tsai, H.-H., Su, C.-Y., Ling, T., Hsu, S., & Lai, D. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05457-9 · Cited by 18 · see citing works
Revolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy
Panos, L. D., Bargiotas, P., Arnold, M., Hadjigeorgiou, G. M., & Panos, G. D. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s460998 · Cited by 18 · see citing works
Placenta-Derived Cells for Acute Brain Injury
Pischiutta, F., Sammali, E., Parolini, O., Carswell, H. V. O., & Zanier, E. R. (2018) · Cell Transplantation · doi:10.1177/0963689717732992 · Cited by 16 · see citing works
Stem Cell Therapies for Intracerebral Hemorrhage: Review of Preclinical and Clinical Studies
Takamiya, S., Kawabori, M., & Fujimura, M. (2023) · Cell Transplantation · doi:10.1177/09636897231158153 · Cited by 13 · see citing works
Song, P., Lei, P., Li, Z., Zhou, L., Wei, H., Gao, L., Li, C., Wang, W., Hua, Q., Chen, Q., et al. (2023) · PubMed Central · Cited by 11 · see citing works
Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage
Ding, N., Luo, R., Zhang, Q., Li, H., Zhang, S., Chen, H., & Hu, R. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01216-7 · Cited by 11 · see citing works
Tao, H., Li, L., Dong, L., Chen, H., Shan, X., Zhuge, L., & Lou, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110779 · Cited by 10 · see citing works
Jiang, X., Zhou, L., Sun, Z., Xie, B., Lin, H., Gao, X., Deng, L., & Yang, C. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00159-7 · Cited by 9 · see citing works
Recent Stem Cell Research on Hemorrhagic Stroke : An Update
Kim, J.-T., Youn, D. H., Kim, B. J., Rhim, J. K., & Jeon, J. P. (2022) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2021.0126 · Cited by 9 · see citing works
Clinical state and future directions of stem cell therapy in stroke rehabilitation
Habib, P., & Steinberg, G. K. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115132 · Cited by 7 · see citing works
Zhang, H., Pan, Y., Jin, L., & Wang, B. (2025) · MedComm · doi:10.1002/mco2.70377 · Cited by 8 · see citing works
Zahra, K., Turnbull, M. T., Zubair, A. C., Siegel, J. L., Venegas-Borsellino, C. P., Tawk, R. G., & Freeman, W. D. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.104931 · Cited by 7 · see citing works
Mesenchymal stem cell for hemorrhagic stroke: A clinical review
de la Calle, S., & Zurita, M. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.05.011 · Cited by 2 · see citing works
Umbilical Cord-Derived Cells: Applications in Neurological Disorders
Vasques, J. F., Chimeli-Ormonde, L., Gubert, F., Méndez‐Otero, R., & Pimentel‐Coelho, P. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00003-2 · Cited by 1 · see citing works
Application of neural stem cells in the treatment of intracerebral hemorrhage: a systematic review
Song, P., Shafiq, Z., Jiang, H., & Cai, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1660614 · Cited by 1 · see citing works
Hsieh, P.-F., Liu, Y.-B., Cordonnier, C., & Tsai, H.-H. C. (2026) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2026.103423 · Cited by 1 · see citing works
Self-citationAdvanced Approaches in Stem Cell Therapy for Stroke and Traumatic Brain Injury
Gorodinsky, A. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781788012539-00214
Stem Cell Delivery Techniques for Stroke and Peripheral Artery Disease
Lee, S.-R., Fereydooni, A., & Dardik, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-56954-9_3
Niryana, I. W., Wibawa, I. B. A., & Kusuma, G. F. P. (2024) · Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) · doi:10.14710/dmj.v13i4.44046
Wei, L., Ren, H., Lin, Y., Sun, J., Nie, S., Gao, X., & Huang, Y. (2026) · Cell & Bioscience · doi:10.1186/s13578-026-01551-w
Chen, L., Hong, C., Guo, X., Liu, J., Cai, J., Chen, L., 毛更生, Xue, M., Pu, J., Kang, D., et al. (2026) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2026.100295
- Authors
- Chang, Z., Mao, G., Sun, L., Ao, Q., Gu, Y., & Liu, Y.
- Affiliations
- China Medical University (CN)
- Chinese People's Armed Police General Hospital (CN)
- Capital Medical University (CN)
- Corresponding author
- Gu, Yongquan
- Liu, Ying
- Venue
- Experimental and Therapeutic Medicine
- Publisher
- Spandidos Publications
- Published
- 2016-10-18
- Volume
- 12
- Issue
- 6
- Pages
- 3535-3540
- ISSN
- 1792-0981 (ISSN-L)
- 1792-1015
- PMC
- PMC5228203
- OpenAlex
- W2535285119
- Cited by
- 34
- References
- 18
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 2
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Experimental and Therapeutic Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National High-tech Research and Development Program (2011AA020101)
- National Institute on Alcohol Abuse and Alcoholism (R03AA020101)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Neurology › Neurosurgical Procedures and Complications
- Keywords
- cerebral hemorrhage, cell therapy, mesenchymal stem cells, umbilical cord-derived stem cells, bone marrow mononuclear cells, autologous transplantation, allogeneic transplantation, functional outcome, T-cell markers, immunogenicity, long-term follow-up
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