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Characterization and predicted role of microRNA expression profiles associated with early childhood obesity

Ouyang, Shengrong, Tang, Renqiao, Liu, Zhuo, Ma, Feifei, Li, Yuanyuan, Wu, Jianxin·2017·Molecular Medicine Reports
DOI 10.3892/mmr.2017.7118PMC PMC5646957
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Figure 1. Analysis of differentially-expressed miRNAs. A total of 76 miRNAs with an expression level greater than 100 code counts are presented. 1–6, lean samples; 7–12, obese samples; miRNA, microRNA.
Figure 1. Analysis of differentially-expressed miRNAs. A total of 76 miRNAs with an expression level greater than 100 code counts are presented. 1–6, lean samples; 7–12, obese samples; miRNA, microRNA.CC BY-NC-ND · PubMed Central
Figure 2. Identification of miRNAs that were differentially expressed between groups (obese vs. lean). Among these miRNAs, miR-199a-3p/miR-199b-3p and miR-4454 exhibited at least a 1.5-fold change in expression. (A) Volcano plot of statistical significance against fold-change of differentially-expressed miRNAs. P<0.05 was considered to indicate a statistically-significant difference. (B) Fold-change of differentially-expressed miRNAs. miRNA, microRNA.
Figure 2. Identification of miRNAs that were differentially expressed between groups (obese vs. lean). Among these miRNAs, miR-199a-3p/miR-199b-3p and miR-4454 exhibited at least a 1.5-fold change in expression. (A) Volcano plot of statistical significance against fold-change of differentially-expressed miRNAs. P<0.05 was considered to indicate a statistically-significant difference. (B) Fold-change of differentially-expressed miRNAs. miRNA, microRNA.CC BY-NC-ND · PubMed Central
Figure 3. Protein-protein interaction network of predicted miRNA-targeted genes. The 14 hub genes with a degree of >10 are indicated in red. The size of the node indicates the number of interactions with other nodes within the network. miRNA, microRNA.
Figure 3. Protein-protein interaction network of predicted miRNA-targeted genes. The 14 hub genes with a degree of >10 are indicated in red. The size of the node indicates the number of interactions with other nodes within the network. miRNA, microRNA.CC BY-NC-ND · PubMed Central
Figure 4. miRNA-GO network analysis. Red box nodes represent miRNAs, and green circle nodes represent GO terms. Edges indicate the inhibitory effect of miRNAs on target genes. GO, gene ontology; miRNA, microRNA.
Figure 4. miRNA-GO network analysis. Red box nodes represent miRNAs, and green circle nodes represent GO terms. Edges indicate the inhibitory effect of miRNAs on target genes. GO, gene ontology; miRNA, microRNA.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., & Wu, J.
Venue
Molecular Medicine Reports
Publisher
Spandidos Publications
Published
2017-07-31
Volume
16
Issue
4
Pages
3799-3806
ISSN
  • 1791-2997
  • 1791-3004
DOI
10.3892/mmr.2017.7118
PMC
PMC5646957
Cited by
25
References
2
Language
en

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